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Doctor insights on: What Causes White Matter On The Brain

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What would cause loss of white matter in the brain in 3 years time? I have comparison pics in my profile

What would cause loss of white matter in the brain in 3 years time? I have comparison pics in my profile

GENERIC RESPONSE: Loss of "white matter" could be associated with multiple brain lesions, such as MS, vasculitis, CADASIL, but also may be due to solvent exposure, glue sniffing, and best that we review your films to give you a more precise answer. Also, useful, is description of your symptoms. Maybe better using inbox consult. ...Read more

White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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Whay causes spots on white matter of the brain?

Whay causes spots on white matter of the brain?

Many causes: White matter lesions can be caused by a very wide range of things, ranging from toxic exposure to multiple sclerosis to hypertension to chronic migraines. A neurologist can help you put the imaging findings into perspective with the rest of your clinical picture, and guide further workup and treatment as needed. ...Read more

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Why a build up of sulfatides in the white matter of the brain will cause the myelin sheath to deteriorate?

Why a build up of sulfatides in the white matter of the brain will cause the myelin sheath to deteriorate?

Complex: There are a series of lysosomal enzyme disorders, metachromatic leukodystrophy being one, which can be diagnosed by measurement of aryl sulfatase. Build up of any chemical imbalance especially presence of misfolded proteins, can interfere with normal cellular metabolism, and cause repair attempts to fail. Some of these disorders are associated with inflammation, and this too causes damage. ...Read more

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On brain MRI what does "mild to moderate deep white matter flair hyperintensity burden" mean? What would cause be?

On brain MRI what does "mild to moderate deep white matter flair hyperintensity burden" mean? What would cause be?

Complex question: Why did u get an MRI? FLAIR is "fluid attenuation by inversion recovery," 1 of many ways that MRI signals r obtained. Hyperintensity means the signal was stronger than expected. I suspect this is an artifact of MRI, unrecognized by the radiologist. If you are feeling no different than before, & if you have no symptoms, I wouldn't worry too much. http://www.actaneurocomms.org/content/1/1/14 ...Read more

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Could cryofibrinogenemia cause multiple t2 hyperintensities in the periventricular and deep white matter of the brain?

Could cryofibrinogenemia cause multiple t2 hyperintensities in the periventricular and deep white matter of the brain?

Mixed cryoglobulin: Most of the literature regarding cryoglobulinemia and neurologic complications is in reference to peripheral neuropathies and not central nervous system dysfunction. Hence, another cause should be sought for the mr abnormalities. Good luck and well wishes. ...Read more

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In a 45 yr old, what are the possible causes of multiple small t2 hyperintensities in periventricular and deep white matter of brain if spine clear and not in MS pattern? Significant or dismiss?

In a 45 yr old, what are the possible causes of multiple small t2 hyperintensities in periventricular and deep white matter of brain if spine clear and not in MS pattern?   Significant or dismiss?

Usually strokes: It depends on the patient's history. Migraines have been associated with hyperintense spots in the brain. Uncontrolled diabetes mellitus, hypertension, or hyperlipidemia may cause "silent" small strokes which can also take on a similar experience. Have a neurologist evaluate you as a whole in conjunction with the mri, not just the MRI alone. ...Read more

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Can ischemic small vessel disease cause gliosis? How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Can ischemic small vessel disease cause gliosis?  How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Yes.: White matter changes frequently seen on brain MRI are the result of chronic small vessel ischemic disaease and it is the resulting small focus of gliosis that shows on the MRI imaging. Treating your underlying cardiovascular heath is key, not the MRI finding. ...Read more

Cerebrum (Definition)

Cerebrum essentially refers to the majority of the brain. Embryologically, it develops from the telencephalon, and together with the diencephalon, ...Read more