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Doctor insights on: What Causes Pancreatic Cancer

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Dr. Christian Schultheis Dr. Schultheis
Internal Medicine - Hematology & Oncology
20 years in practice
American University of the Caribbean
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Can anyone tell me what causes pancreatic cancer?

Can anyone tell me what causes pancreatic cancer?

A lot of causes: Smoking, diabetes, BRCA (breast cancer) gene mutations, family history. These are a few. Hope this helps.

Dr. Barry Rosen
4,330 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Dr. Myron Arlen Dr. Arlen
Surgery - Oncology
60 years in practice
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What causes pancreatic cancer? What are the symptoms and how is it treated?

What causes pancreatic cancer? What are the symptoms and how is it treated?

Probably viral: Pancreatic Ca is a lethal disease of probable viral origin. The tumor begins 15-20 yrs before a clinical lesion can be defined. It appears in the head where painless jaundice is seen, in the body with symptoms of invasion of celiac plexus and tail with pseudo varices of vasa brevia. Even with surgery for 10% of patients the survival here is 10%. Chemo with gemzar (gemcitabine) and Abraxane used.

Dr. Myron Arlen Dr. Arlen
Surgery - Oncology
60 years in practice
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What can cause pancreatic cancer?

What can cause pancreatic cancer?

Probable viral: Pancreas cancer starts out as an intraductal lesion similar to breast DTIC (dacarbazine). It smolders within the ductal system for 15-20 yrs before first signs of ductal wall invasion to become an early pancreatic carcinoma. The TAA that are expressed early are oncofetal in origin and are suppressed at birth to reappear in the tumor as the oncogenic protein. Transformation probably viral induced.

Dr. Richard Bensinger Dr. Bensinger
Ophthalmology
48 years in practice
Johns Hopkins University School of Medicine
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I want to know what's the cause of pancreatic cancer?

I want to know what's the cause of pancreatic cancer?

So do we: Pancreatic cancer seems to be a spontaneous event and because it is internal with no early symptoms, is rarely detected until it has spread beyond meaningful treatment. No one knows the cause. There is much investigation being done to provide earlier detection and discover the cause.

Dr. John Valente Dr. Valente
Surgery
30 years in practice
UC San Francisco School of Medicine
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Been having white globs in my stool that float. What could cause besides pancreatic cancer? Could it be cancer? I had pancreatitis a few years ago.

Been having white globs in my stool that float. What could cause besides pancreatic cancer? Could it be cancer? I had pancreatitis a few years ago.

Doubt its cancer: Floating stool without much color usually indicates poor absorption of fat from your diet. A poorly functioning gallbladder, pancreas or small intestine can be involved. While pancreas cancer can cause such symptoms this is not the usual way cancer is found and 29 is a bit young for pancreas cancer but you should see your doctor to get the other issues on the list checked.

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Dr. Debashish Bose Dr. Bose
Surgery
15 years in practice
University of Maryland School of Medicine
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What are the causes of pancreatic cancer?

What are the causes of pancreatic cancer?

Multifactorial: Pancreatic cancer (adenocarcinoma) is caused by the accumulation of mutations in the dna of cells that line the pancreatic duct. Smokers, diabetics, and people with chronic pancreatitis are at increased risk, as are some people with familial (genetic) syndromes. Another type, neuroendocrine (like steve jobs) arise from hormone-producing cells and some are related to inherited cancer syndromes.

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Dr. Andrew Turrisi Dr. Turrisi
Radiation Oncology
43 years in practice
Georgetown University School of Medicine
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Does pancreatic cancer usually cause many symptoms?

Does pancreatic cancer usually cause many symptoms?

Yup...: Commonly yellow skin; +/- belly pain; weight loss; new onset diabetes and depression. Pancreas tail makes hormones: insulin, gastrin, glucagon - these cause symptoms. Head/body make digestive juice, and engulf the duct draining the liver into the gut. This is a very nasty cancer.

Dr. Crystal Twynham Dr. Twynham
Surgery
29 years in practice
University of Minnesota Medical School
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My pancreatic cancer: causes, & symptoms, as well as cure?

My pancreatic cancer: causes, & symptoms, as well as cure?

Unsure of question!: Do YOU have pancreas cancer? That is very rare in someone in their 30s. No one knows what causes pancreas cancer. Symptoms are usually upper mid-abdominal pain near the breast bone, often after eating going into the back, weight loss, loss of appetite, change in taste/smell sensation, blood clot in leg, depression. Early pancreas cancer's best chance for cure is surgery.

Dr. Jack Rubin Dr. Rubin
Internal Medicine - Nephrology & Dialysis
44 years in practice
State University of New York Downstate Medical Center College of Medicine
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Please tell me what are some of the causes fo pancreatic cancer?

Please tell me what are some of the causes fo pancreatic cancer?

Pancreatic cancer: Pancreatic cancer (p) is due to dna mutations, and there are three ways that we can damage our dna. We can be born with a dna mutation inherited from either parent, we can damage our dna by smoking, or our dna can be damaged by chance. Risk factors for p are increasing age, diabetes, being a male, being obese and eating a high cholesterol diet and being black.

Dr. Clarence Grim Dr. Grim
Internal Medicine - Endocrinology
53 years in practice
University of Missouri-Columbia School of Medicine
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Can pancreatic cancer cause only mild symptoms? How can I know if I have it?

Can pancreatic cancer cause only mild symptoms? How can I know if I have it?

Pancreatic cancer: 21 M from LA. Asks: Can pancreatic cancer cause only mild symptoms? How can I know if I have it? ANS: Time will tell. Dr. humor here. All diseases go thru evolution of Sx as does CA pancreas. At your age CA pancreas is VERY rare. Discuss with your Drs & they can help u. If u don't wear your seatbelt start doing that now. Only way 2 tell is 2 take out pancreas. But u get diabetes etc 4 life.

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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I've read some reports that soda can cause pancreatic cancer. Is this true? Has it been proven?

I've read some reports that soda can cause pancreatic cancer. Is this true? Has it been proven?

I don't believe it: My physician-colleagues disagree among ourselves about whether aspartame is a health threat of any kind, but I've seen nothing to make me believe it can mutate genes. I saw the 2010 prospective study on the sugary stuff & was underwhelmed -- the numbers are small, there's no obvious mechanism, some confounding variable seemed likely. Why not some nice fruit juice instead?

Dr. Eric Chevlen Dr. Chevlen
Internal Medicine - Oncology
43 years in practice
The Ohio State University College of Medicine
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If I had idiopathic PE a year ago and it was caused by pancreatic cancer would I have symptoms of PC yet? Just scared I have PC.

If I had idiopathic PE a year ago and it was caused by pancreatic cancer would I have symptoms of PC yet? Just scared I have PC.

Not pancreas cancer: While deep vein thrombosis (DVT) is common as a complication of pancreatic cancer, it is VERY rare for that to be the first sign of the disease. You are not at above-average risk of pancreatic cancer.

Dr. Morton Levitt Dr. Levitt
Pathology
45 years in practice
Duke University School of Medicine
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What part of the back does pancreatic cancer cause pain? Is it constant or can the pain come and go? What does the pain feel like?

What part of the back does pancreatic cancer cause pain? Is it constant or can the pain come and go? What does the pain feel like?

Back Pain: Pancreas: The pain is usually in the mid back; it may begin intermittently but then may get worse and more constant. Often aggravated by lying down and/or after meals. The pain is often described as "severe." Opioid pain medications van often ameliorate the pain.

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Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Does alcohol cause pancreatic cancer?

Maybe: Whether alcohol abuse is an important risk factor for pancreatic cancer isn't clear; smoking clearly is. Abuse alcohol though and you're asking for chronic pancreatitis, a confusingly-named lifetime severe pain syndrome involving damage to the deep nerves of the area. You don't want that, or any of several other unpleasant sequelae. Best wishes; make smart decisions & drink moderately if at all.

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Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Could high level of amalyse cause pancreatic cancer?

Could high level of amalyse cause pancreatic cancer?

No: Abnormal lab tests are indicators, not causes of anything. However, if you have familial pancreatitis caused by a mutant trypsinogen gene, it often turns into pancreatic cancer eventually. Your physician is aware of this and can advise you.

Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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Why/how does pancreatic cancer cause early satiety?

Why/how does pancreatic cancer cause early satiety?

Symptom of abdominal: Many different Cancers in the abdomen can cause early satiety. It is a presenting symptom for stomach, Ovarian cancer as well as pancreatic cancer (sometimes). If it persists or you are losing weight, you should consult your doctor without a delay of more than 1 or 2 weeks.

Dr. Clarence Grim Dr. Grim
Internal Medicine - Endocrinology
53 years in practice
University of Missouri-Columbia School of Medicine
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Can pancreatic cancer cause iron levels to increase?

Iron pancreas cancer: 33 M Ottawa: Can pancreatic cancer cause iron levels to increase? ANS: Can recall no biologically plausible mechanism for this to happen. But discuss with your Drs who know you and your metabolism best.

Dr. Myron Arlen Dr. Arlen
Surgery - Oncology
60 years in practice
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Friend's brother died of pancreatic cancer at 32. Used to be a drinker. What would cause it so early?

Friend's brother died of pancreatic cancer at 32. Used to be a drinker. What would cause it so early?

Possible viral cause: pancreatic cancer begins at least 15 years before an early invasive lesion is present. Teen agers have been reported with panc. CA. The probable cause is a virus getting into the tissues to cause transformation though disease like melanoma and chronic pancreatitis are associated with higher incidence.

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Dr. Marc Goldhagen Dr. Goldhagen
Occupational Medicine
29 years in practice
George Washington University Medical School
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Does pancreatic cancer cause itching?

Does pancreatic cancer cause itching?

It can: If cancer blocks bile duct connection to bowel you can have elevated bilirubin (jaundice) which can cause itching.

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Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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Why does pancreatic cancer cause nausea?

Why does pancreatic cancer cause nausea?

Many possible reason: Nausea is a non-specific symptom and can occur for many different reasons or diseases affecting the abdomen. It can originate in any part of the digestive tract. So you need to get a check up with your doctor and seek medical therapy. You may benefit from cusing anti nausea pills (there are several different ones that can help). Any liver dysfunction (this is common with pancreatic Cancer) can cause

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Dr. Lawrence Kessler
3 Doctors shared insights

Pancreas (Definition)

Abdominal organ. It is digestive organ: it secretes enzymes into the small bowel which break down food and help its absorption. It is also an endocrine organ: it produces hormones involved in sugar control and control of digestion. Insulin is one of these hormones. Diabetics either lack Insulin (type 1 diabetes) or have inadequate ...Read more


Dr. Debashish Bose
405 Doctors shared insights

Pancreatic Cancer (Definition)

Fast growing abnormal cells that are difficult to diagnose at an early stage & only sometimes can be removed with surgery. Endocrine cancers tend to be slower growing ...Read more