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Doctor insights on: What Causes Muscular Dystrophy When Kids Have It

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What causes muscular dystrophy when kids have it ?

What causes muscular dystrophy when kids have it ?

Genetics: Muscular dystrophies are caused by mutations in the genes responsible for making the components of muscle. Sometimes these mutations are sporadic, while in other cases there is a family history. A neurologist or geneticist can help you determine the specifics of your case and if genetic testing of the patient or their family members might be useful. ...Read more

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Dr. Kathryn Mosher
141 doctors shared insights

Muscular Dystrophy (Definition)

Muscular dystrophy includes a number of disorders which are associated primarily with abnormalities of the architecture of the cells, often causing changes in size and function (weakness). These disorders are typically inherited, and recognized early in life, although there are of course exceptions to this. Prognosis is based on the type of MD and expression ...Read more


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Do lots of people get muscular dystrophy, or is it unusual?

Do lots of people get muscular dystrophy, or is it unusual?

Relatively common: The incidence of duchenne md is 1 in 3500 male births, with 1/3 of the cases caused by new mutations. Another md, myotonic md has an incidence of about 13.5/100, 000 live births. Most of the other muscular dystrophies are much less common, are frequently genetically transmitted or regional clustered (oculopharyngeal md in french canadians) or are sex linked(emery-dreifuss). ...Read more

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Is it normal to injure and tear muscles if I have muscular dystrophy?

No: Usually weakness, fatigue, sometimes cramps are the usualy symptoms associted with muscular dystrophy. Tearing a muscle usually comes for exagerrated activited or stress to the muscle by overactivity. Most people with muscular dystrophy do not overuse their muscles because they are weak. However, it would be possible and should be treated immediately. ...Read more

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What kind of experience is it to have muscular dystrophy?

Muscular dystrophy: The muscular dystrophies all share progress weakness. The distribution and degree of weakness are dependent on the type of muscular dystrophy. The most significant problem is weakness and difficulty carrying out motor tasks such as lifting objects and walking. Individuals find they fatigue easily and it takes increasing effort to do tasks. There is no pain associated dystrophy. ...Read more

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Is it okay to procreate if I have mild heart failure and duchenne muscular dystrophy?

Please check...: With your doctor if your degree of heart failure is safe for sexual activity, or even taking care of a child! given your age, it appears you have done remarkably well with a diagnosis of duchenne's md. However, please keep in mind that if you and your partner have a girl, she will automatically be a carrier of the disease. ...Read more

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For what reason might duchenne muscular dystrophy appear in some body regions but not others?

For what reason might duchenne muscular dystrophy appear in some body regions but not others?

Certain muscles are: More prone to md starting in those areas, but as it is progressive, will most likely eventually start causing problems in more and more muscle groups. The progression can be different for all and use, muscle health and types of md can affect which groups show up first and how progressive it is. ...Read more

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What causes leg cramps?They're brief but they hurt.No twitching, happens at research.I do have sciatica and hypothyroid. Is it related to either?

What causes leg cramps?They're brief but they hurt.No twitching, happens at research.I do have sciatica and hypothyroid. Is it related to either?

Yes: Could be either. Could also be muscle tightness and electrolyte imbalances as well. Suggest seeing your doctor to determine which it is. ...Read more

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What to do if I have mitochondrial myopathy in my skeletal muscles. could it spread to other places of my body?

What to do if I have mitochondrial myopathy in my skeletal muscles. could it spread to other places of my body?

Which one? : Prognosis depends on which mitochondrial myopathy was diagnosed by Chromosomal Microarray, other genetic test or muscle biopsy, as each may affect different organs, with overlap. If your neurologist told you the type you have, please ask about it specifically. If not, seek referral to a geneticist for diagnostic evaluation. See http://mda.org/disease/mitochondrial-myopathies/overview. ...Read more

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Is it possible to regain muscle mass if I have muscular dystrophy?

Is it possible to regain muscle mass if I have muscular dystrophy?

It depends...: ...On the type and severity of your condition. Muscular dystrophy is a group of inherited conditions with variable severity and rate of progression. If you have a milder form with slower progression, it is feasible to obtain limited benefit from training. ...Read more

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What causes hypertrophy of calves in kids with Duchenne? Is it because of how they walk and over use calve muscles or something else?

What causes hypertrophy of calves in kids with Duchenne? Is it because of how they walk and over use calve muscles or something else?

Something else: In brief it's caused by the lack of dystrophin allowing degeneration of muscle fibers and inflammation. If you are in med-school then you need to look it up for yourself ;-) ...Read more

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What causes eyelids to have a twitch.Almost as if it were muscle twitches?

What causes eyelids to have a twitch.Almost as if it were muscle twitches?

Cause is not known: Trembling of an eyelid, which happens in normal people, is called myokymia (an involuntary, spontaneous, quivering of a few muscle cell bundles within a muscle). Myokymia starts and stops spontaneously. In the eyelids, it can last a few minutes to a few days. One should see an ophthalmologist (md eye doctor) if such symptoms persist, keep recurring, or are combined with any other symptoms. ...Read more

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22/male constant hand cramps no weakness , what are chances it could be ALS , it does not run in my family ? Need some peace if mind please !!

22/male constant hand cramps no weakness , what are chances it could be ALS , it does not run in my family ? Need some peace if mind please !!

Rest easy son: With just hand cramps as your symptom and no family history of ALS I would say that Killer Krill that hunt giant Sperm Whales found in the ocean would be more likely to exist than you having ALS with that presentation. In other words, just work on UNcramping your hands a little which could be stress and so forth. If you were inconsolable over this then, see a neurologist to check you over. ...Read more

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What is duchenne muscular dystrophy, where does it strike most?

What is duchenne muscular dystrophy, where does it strike most?

Young boys: Duchenne muscular dystrophy is a recessive x-linked form of muscular dystrophy, affecting around 1 in 3, 600 boys, which results in muscle degeneration. Approximately 14, 000 americans suffer from dmd. ...Read more

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My little brother has duchenne muscular dystrophy. What can I do to help as his health worsens?

Help my muscles: Take him to a shriners hospital or a similar facility and show him the wonderful work they are doing with kids like him they can give. You helpful hints. ...Read more

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Hand pains and knee pains are occurring for my mom. She is having random muscle spasms as well. What do you think this is ?

Depends: I am a neurologist so most pain that i deal with is, of course, from nerve disorders. If the pain in the joints themselves? If so, unlikely to be a nerve problem. ...Read more

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Can you advise on where does duchenne muscular dystrophy strike most?

See below: Usually first become apparent with balance issues such as walking. A thorough history and physical by a medical physician before coming to a diagnosis on your own is recommended ! good luck thank you. ...Read more

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What is the reason why children develop tics, does it have to do with trauma or neurological damage?

What is the reason why children develop tics, does it have to do with trauma or neurological damage?

Neither or both: Tics can occur developmentally around seven years old and dissipate by teenage. However, severe motor movement disorders can be caused by panda's, or inherited as a disease such as generalized anxiety disorder, ocd, or phobias. See the following link: http://www.Pedrheumonlinejournal.Org/april/reviewarti.Htm. ...Read more

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What causes muscular dystrophy when kids have it ?

Genetics: Muscular dystrophies are caused by mutations in the genes responsible for making the components of muscle. Sometimes these mutations are sporadic, while in other cases there is a family history. A neurologist or geneticist can help you determine the specifics of your case and if genetic testing of the patient or their family members might be useful. ...Read more

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What causes frequent respiratory infections in children with duchenne muscular dystrophy ?

Weak respirations: As Duchennes muscular dystrophy progresses, the muscles of respiration become weakened. As a result the person does not have the forceful breathing and cough to clear secretions from the respiratory tract. As soon as a cold begins you should give vigorous chest physical therapy to mobilize the secretions and if necessary suction them. ...Read more

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What is the cause of frequent respiratory infections in children with duchenne muscular dystrophy ?

Impaired muscles: When dmd affects the muscles of breathing, patients have difficulty clearing secretions which can lead to increased infections. Chest pt can be useful to break the secretions up and allow them to be cleared. If there is an issue with scoliosis, this should be addressed early to prevent further repiratory compromise later in the disease course. ...Read more

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What causes duchenne muscular dystrophy?

Genetic disorder: Duchenne's muscular dystrophy is an x linked genetic disorder causing abnormalities of the muscle fiber and eventual degeneration. ...Read more

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What causes duchenne muscular dystrophy?

Hereditary: It is inherited because of a defective gene on the x chromosome (female sex chromosome). It is referred to as a "sex-linked recessive" inheritance pattern. Girls get two x chromosomes, and the healthy one overrules the unhealthy gene, preventing girls from contracting the disorder. Boys get an x and a y. If the x has the defective gene, there is no corresponding gene on the y to overrule it. ...Read more

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Can a person with duchenne muscular dystrophy have children?

Can a person with duchenne muscular dystrophy have children?

Yes but . . .: Yes, there is no reason that a person with duchenne could not reproduce. However, most people with duchenne elect not to because as they get older their health tends to become more fragile. Also if they have daughters they have a 100% chance that their daughters will carry the disease which means their grandsons would be affected. ...Read more

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How does duchenne muscular dystrophy affect the family and kids socialy and economically?

A fair amount: A child with dmd will need many doctors visits and likely some surgeries in their lives. Going to a children's hospital or a multidisciplinary clinic can help lessen the burden. Also, they can point you in the direction of counselors who can help you deal with upcoming challenges. ...Read more

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Is there any complications for men who have Duchenne Muscular Dystrophy? Can they have Children?

Is there any complications for men who have Duchenne Muscular Dystrophy? Can they have Children?

Often rapid decline: This is a very difficult disease and often shortens life significantly. It is genetic so the fact that it reduces fertility can have some benefit too. Passing it on is not desirable. If he wants to share in a child's life - there may be better ways than fatherhood. Sorry. I expect this is sad for you. ...Read more

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Might it be possible that a a person with duchenne muscular dystrophy have children of their own?

Yes: Fertility isn't affected. All the daughters will be carriers; all the sons will be unaffected unless the mother is a carrier and transmits the gene. The prognosis for duchenne's remains bleak, and the decision to become a parent is the most gravely serious decision that one can make. ...Read more

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What mutation type causes duchenne muscular dystrophy?

What mutation type causes duchenne muscular dystrophy?

DMD is caused by: mutation of Xp21.2-p21.1, a large gene that encodes dystrophin, a muscle protein. Deletions in specific areas of the gene are associated with cognitive impairment, verbal memory, auditory comprehension, increased risk of ADHD & Autistic Spectrum Disorder. Each son of a carrier mom has a 50% chance of having DMD. Carrier girls can have muscle weakness, including heart. See mda.org & a geneticist. ...Read more

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What mutation type causes duchenne muscular dystrophy?

What mutation type causes duchenne muscular dystrophy?

Duchenne MD: Duchenne muscular dystrophy is caused by a defective gene for dystrophin (a protein in the muscles). It is inherited in an X-linked recessive fashion, but it often occurs in people from families without a known family history of the condition. Children with the condition should be followed with a multi-specialist team approach ...Read more

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What is duchenne muscular dystrophy?

X-Linked Reces. MD: Duchenne dystrophy is inherited as an x-linked recessive trait, carried in women. It affects about 1in 3500 male births with no geographic/ethnic variation. About 1/3 of the cases are caused by new mutations, the others are familial. Diagnosis is usually evident from clinical features. The abnormality is in the cytoskeletal protein dystrophin. It is unclear why the lack of dystrophin ->findings. ...Read more

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What sort of disorder is duchenne muscular dystrophy?

What sort of disorder is duchenne muscular dystrophy?

Muscle weakness: Dmd is a condition when muscles start to die prematurely. It starts in early childhood, leads to weakness of voluntary muscles such as those of hips, pelvic area, thighs and shoulders. Calves are often enlarged. Eventually it involves all muscles including that of heart and that control breathing. Life span is shortened to less than 30 years. It is a genetic condition primarily in boys. ...Read more

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What are the symptoms of duchenne muscular dystrophy?

Weakness...: ...More prominent in large muscles than in small ones, progressing to inability to stand up without assistance (see http://en.Wikipedia.Org/wiki/gower_maneuver ); muscles are enlarged early on ("pseudohypertrophy) but wither later. ...Read more

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What are medications for duchenne muscular dystrophy?

Steroids: Currently the mainstay of therapy for duchenne is still steroids. Steroids slow the progression of the disease but are not a cure. There are many promising therapies being tested, but so far no others available at this time. For more information visit mda.Org or duchenneconnect. ...Read more

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Could you explain what is duchenne muscular dystrophy?

See link below: "duchenne results in progressive loss of strength and is caused by a mutation in the gene that encodes for dystrophin. Because dystrophin is absent, the muscle cells are easily damaged. The progressive muscle weakness leads to serious medical problems, particularly issues relating to the heart and lungs." - see more at: http://www.Parentprojectmd.Org/site/pageserver?Pagename=understand_about#sthas. ...Read more

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How did our ancestors on the prairie treat duchenne muscular dystrophy?

They Didn't: Although today's treatment is very limited, our ancestors other than supportive devices, had no real therapy. ...Read more

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Is there any way to prevent inheriting duchenne muscular dystrophy?

Abortion: The dystrophin gene can be detected in the fetus. If such testing proves the fetus is male and has the full defect, abortion is an option. There is no way to predict severity of the disorder. There is no way to prevent development of the disorder. Steroid therapy can be started early to try to modify the disorder. ...Read more

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How does one acquire duchenne muscular dystrophy?

Bad genes: Duchenne type of muscular dystrophy is located on the x chromosome and is found in males. There are specific genetic tests that describe the disorder in detail. Women are carriers, and boys develop symptoms during early childhood. In utero testing is available. There is no cure, but early detection and possible use of steroids with appropriate therapy may modify the course. ...Read more

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