Doctor insights on:
What Causes Lupus To Be Widespread Or Localized
Genes, environment: This answer will change as we know more about lupus. We believe that for a person to get lupus, from the limited genetic information we have now, about 10% is from known genetic causes and remaining 90% unknown genetic causes and environmental causes. Environmental causes are largely undefined but important. Think about this: only 30% of identical twins develop lupus together. ...Read moreSee 1 more doctor answer
NOT KNOWN...: No one knows the final "trigger-pull" that causes lupus. We do know genetics play some role. We do know that hormones play a major role (reason for female dominance and females rarely getting sle before puberty). But why some with similar factors get disease is not known at present. ...Read moreSee 1 more doctor answer
Skin cancer?: Atypical acid fast bacilli often causes sores which do not heal or respond to the usual antibiotics. I always consider the presence of a skin cancer if a sore fails to heal . See a dermatologist. A less likely scenario would be the presence of an immune defect. ...Read moreSee 2 more doctor answers
SLE diagnosis: Systemic lupus erythematosus is best diagnosed by an experienced rheumatologist. It is an autoimmune disease. A high-titer ANA, >1:320 is both sensitive and specific for lupus. Other auto-antibodies can help to confirm the lupus diagnosis. Anti-Smith is highly specific for lupus but not very sensitive. Anti-dsDNA is also highly specific and tends to be seen in lupus with kidney involvement. ...Read more
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