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Doctor insights on: What Causes Low Grade Liposarcoma To Upgrade To High Grade Liposarcoma

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What causes low grade liposarcoma to upgrade to high grade liposarcoma?

What causes low grade liposarcoma to upgrade to high grade liposarcoma?

Hard to say: There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade. There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas. ...Read more

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Please answer! what would cause low grade liposarcoma to upgrade to high grade liposarcoma?

Please answer! what would cause low grade liposarcoma to upgrade to high grade liposarcoma?

Common change: most liposarcomas begin as benign lipomas that are small. As the lesion progresses to enlarge the potentail that a malignant transformation has taken place holds true. Once there is a low grade liposarcoma, within the field , mutations continue to appear and represent transformation to high grade phenotypes ...Read more

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What is the survival rate of liposarcomas?

What is the survival rate of liposarcomas?

Depends: Depends on the stage. More advanced stages have shorter life expectancy. Also, remember that these are statistics, and predictable for a group of individuals, not a single individual. Talk to your health care team about your specific case. Hope this helps! ...Read more

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I have 6 rubbery, immobile lipomas that feel attached to left upper ab wall. Sizes range from pea to grape. Can it be liposarcomas? DX w gastritis too

I have 6 rubbery, immobile lipomas that feel attached to left upper ab wall. Sizes range from pea to grape. Can it be liposarcomas? DX w gastritis too

Unlikely: Sarcomas are very rare tumors, and usually don't present like this. If you're worried, you could request that one be removed to make sure, or that all are removed. Multiple small lipomas can continue to form. They have nothing to do with gastritis. Hope this helps! ...Read more

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I had a partial Nephrectomy due to Liposarcoma. Did this cause my Adrenal Gland to stop functioning? I am now on Steroids.

I had a partial Nephrectomy due to Liposarcoma. Did this cause my Adrenal Gland to stop functioning? I am now on Steroids.

Lose an adrenal?: Hi. Even if you lost the adrenal on the side that had the partial nephrectomy, the remaining adrenal would be enough to provide all the cortisol and aldosterone you need. What "steroid" are you on? It's not listed in your meds (except for cortisone injections in ankle). Did your doc diagnose you with adrenal insufficiency? We need more info. Good luck! ...Read more

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Can a liposarcoma appear as a lipoma on ultrasound? And do they cause sharp pain? Can they occur in the arm?

Can a liposarcoma appear as a lipoma on ultrasound? And do they cause sharp pain? Can they occur in the arm?

No pain: Liposarcomas can arise where ever fat is present in the abdomen and extremities. When malignant transformation occurs it does not do so uniformly throughout a relatively large lesion. To be sure of pathology whole lesion should be resected and one can find lipoma with select areas of malignant transformation as well as myxomatous components.Pain is rarely associated with lipoSa. Sono of no value ...Read more

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What is a liposarcoma?

What is a  liposarcoma?

Liposarcoma: Is a malignant tumor that arises in fat cells in deep soft tissue and is most frequent in middle-aged and older adults (age 40 and above). ...Read more

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Could you live with liposarcoma?

Could you live with liposarcoma?

No: Liposarcoma is a malignant tumor that will progress and eventually metastasize. Depending where it originates different approaches for removal are needed. In the extremity a muscle group dissection is needed for the larger tumor. In the retroperitoneum, rmoval of the kidney may be necesassary. The lesions larger than 10 cm. must have RT to prevent recurrence. ...Read more