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Doctor insights on: What Causes Low Grade Liposarcoma To Upgrade To High Grade Liposarcoma

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What causes low grade liposarcoma to upgrade to high grade liposarcoma?

What causes low grade liposarcoma to upgrade to high grade liposarcoma?

Hard to say: There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade. There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas. ...Read more

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Please answer! what would cause low grade liposarcoma to upgrade to high grade liposarcoma?

Please answer! what would cause low grade liposarcoma to upgrade to high grade liposarcoma?

Common change: most liposarcomas begin as benign lipomas that are small. As the lesion progresses to enlarge the potentail that a malignant transformation has taken place holds true. Once there is a low grade liposarcoma, within the field , mutations continue to appear and represent transformation to high grade phenotypes ...Read more

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I need to know what is treatment for extensive high grade ductile carcinoma in situ?

I need to know what is treatment for extensive high grade ductile carcinoma in situ?

Excision and XRT: The standard treatment for high grade dcis is complete excision of the abnormal area(calcification and any palpaable tumor) followed by radiotherapy on recovery from surgery. It is best to then take tamoxifen as adjuvant therapy for 5 years. Good luck. ...Read more

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I wanted to know is chemotherapy effective on high grade spindle cell sarcoma?

I wanted to know is chemotherapy effective on high grade spindle cell sarcoma?

Some help: High grade spindle cell sarcomas are aggressive and every effort to remove the primary, control the surgical site if larger than 10 cm with RT should be made. If metastatic foci are noted surgical resection can also benefit as seen with lung mets. Primary treatment with drugs like Ifosfamide and platinum may help but primary removal is most important ...Read more

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What is prognosis for high grade abdominal sarcoma ?

Depends: This will depend in the size of the tumor, was it resectable? Even if it was radiation is needed for high grade tumors. Even with the best case features these are aggressive and can recur or spread. So prognosis will depend on every factor i asked about including whether there has already been any spread of the sarcoma. ...Read more

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Do I need chemotherapy for a low grade serous carcinoma?

Do I need chemotherapy for a low grade serous carcinoma?

Need good Gyn Doc: You must seek an opinion from a Gynecologist and a medical oncologist. Serous Carcinoma(?Ovay) , by definition is expected to be high grade. So first order of business is to confirm the diagnosis. Then find out the stage of your cancer. if the tumor is stage-3 or more, then you would likely have to take chemotherapy. ...Read more

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Would you define low grade myelodysplastic syndrome lesions?

Dr. Le Wang Dr. Wang
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Would you define low grade myelodysplastic syndrome lesions?

MDS: MDS is a group of conditions that involve in abnormal bone marrow changes and lead to inffective blood cell production. Using a comlicated system, MDS can be devided into low-grade (20%). Low-grade MDS does not require chemotherapy and is primarily treated with supportive care. ...Read more

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Help please! is chemotherapy effective on high grade spindle cell sarcoma?

Help please! is chemotherapy effective on high grade spindle cell sarcoma?

Yes it often is: Spindle cell cancers are often called sarcomas. They can arise either in the soft tissues or in the bones. Ask your doctor what is the name of your cancer? If it is a sarcoma, chemotherapy is useful in about half of the cases, often it is used in conjunction with surgery and radiotherapy. ...Read more

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How bad is diagnosis of invasive ductal carcinoma high grade?

How bad is diagnosis of invasive ductal carcinoma high grade?

Depends: Not all breast cancers are the same and many other factors help to predict better or poorer outcomes such as tumor grade, # of positive lymph nodes, estrogen receptor status, her2neu status, etc. A score called oncotype DX based on genetic profiling of the cancer helps define prognosis also and tailor decisions as to the best and most beneficial treatment to use. ...Read more

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Low grade glioma possibly Oligodendroglioma, surgery or wait and see best option?

Low grade glioma possibly Oligodendroglioma,  surgery or wait and see best option?

Need more info: Treatment of this neoplasm depends on the type and site of the tumor and your general health status. I would suggest that you consult with at least two neurosurgeons at a large medical institution to get their opinions. You need expert opinions in order to do followup ...Read more

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What is the normal rate of tumor progression from a low grade to a high grade especially if already at stage IV ..

What is the normal rate of tumor progression from a low grade to a high grade especially if already at stage IV ..

No relation: We mislead by inferring that grade changes, or that if it is lower grade, it's "caught early". Stage and staging agreement that size, location, invasiveness; nodes; presence or absence declare what the cancer has already done when first diagnosed. People mistake progression as a change in stage, it's progressed stage ii not stg iii. ...Read more

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Is it possible for breast high grade ductal carcinoma insitu (dcis) to spread to the major organs ?

Is it possible for breast  high grade ductal carcinoma insitu (dcis) to spread to the major organs  ?

Yes, though rare. : We know that a very small % of pts with high-grade dcis will have lymph node involvement, of which a smaller % can develop distant (metastatic) disease. ...Read more

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What do you mean by low grade in colon cancer?

What do you mean by low grade in colon cancer?

Tumor cell growth: Pathologist will predict the out come by criteria by grading high or low the cancer cell growth, fast growing rapidly dividing , poorly differentiated cell not even resemble the tissue , has several cancer cells in the field etc will have poor prognosis, reverse is in slow growing low grade tumor will have better prognosis. ...Read more

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I get my lab result they said there is epithelial cell abnormality low grade squamous intraepithelial lesion, colposcopy required, what I have?Dangrous

I get my lab result they said there is epithelial cell abnormality low grade squamous intraepithelial lesion, colposcopy required, what I have?Dangrous

Cervical changes: You have changes to the outer cells of the cervix---a sign that you've come in contact with the hpv virus. A colposcopy allows your md to look at these cells with the aid of a microscope and possibly take a biopsy to see if they are pre-cancerous. Likely your body will fight off the virus and the cells will return to normal. Follow all your doctors recommendations though, to prevent cancer. ...Read more

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Where I can get best treatment in India for brain tumor (suspecting high grade glioma) ?

Sorry, no idea BUT-: I can give you a website that you can look at which is also telemedicine like this one but it is actually based out of India so most of the participating docs are from India. They will know for sure where the good hangouts are for getting something like that taken care of.....www.healthcaremagic.com ...Read more

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Is low grade squamous intraepithelial lesion cancerous? How treated? How detected? Have colonoscopy usually next step? Should we worry?

Is low grade squamous intraepithelial lesion cancerous? How treated? How detected? Have colonoscopy usually next step? Should we worry?

? Location: You need to tell us where is this lesion located? is it on your cervix or anal area? It is not cancer but it is pre-cancer, so it needs to be monitored as it can occasionally change into high grade lesion which is more prone to becoming cancerous. You are ok right now. ...Read more

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High wbc, plt, tnf-a. Persistent low grade fever(99.5-101.5), 5w preg, on p4 supp. How do you diagnose whether fever is from cytokines or infections?

High wbc, plt, tnf-a. Persistent low grade fever(99.5-101.5), 5w preg, on p4 supp. How do you diagnose whether fever is from cytokines or infections?

Fever: One of the major stimuli for the hypothalamus to adjust the body temperature is the production of cytokines. These are substances released from one cell which affect the behavior of other cells and one of the primary stimuli for the release of cytokines is infection. The story you tell suggests that you have a chronic focus of inflammation and this may well be due to infection. See your doctor. ...Read more

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How is low grade lymphoma usually treated?

How is low grade lymphoma usually treated?

Still controversial: Current thinking is that if in early stages, it may be ok to just follow since it is so slow growing. May not cause a problem for years. If more advanced, currently chemotherapy combined with immune therapy (usually a monoclonal antibody called rituximab) is used. Most patients can achieve remission but the disease is currently not considered curable. ...Read more

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