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Doctor insights on: What Causes Elevated Tumor Markers In Ca 125 Test

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Dr. Amanda Itzkoff
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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How accurate is a CA-125 tumor marker blood test for cancer? Thanks for your time

How accurate is a CA-125 tumor marker blood test for cancer? Thanks for your time

Ca125: Good question. The test is helpful in relation to a woman who has a adnexal mass noted on exam and ultrasound. The test has not been helpful for general screenig. ...Read more

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Ca125 level is a marker for which tumor?

Ca125 level is a marker for which tumor?

Ovarian: It is neither sensitive nor specific for screening. However, its recurrence after removal of a tumor that produces it suggests recurrence. ...Read more

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Stg 1/grd 1 mucus rght ovary tumor w/o stroma invasion '13/CA125 went from 26.9 to 31.2 on last test '15/Low dense spots found near right broad ligame?

No mets: Gr1 without stromal invasion probably based on salpingo oophorectomy should be cured. Rt broad lig nodules probably inflammatory nodes. Ca 125 not good for dx but for monitoring. When ovary spreads the marker jumps several hundred points, not just 4. In 4 months repeat scan. If there is a significant change then bx needed but doubt this will occur. ...Read more

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Common causes to order a tumor marker AFP test?

Liver and testicular: An alpha-fetoprotein (AFP) is a blood test that checks the level of AFP in a pregnant woman's blood. It is a substance made in the liver of the fetus. The level of AFP in the blood of a pregnant woman can help see whether the baby may have chromosomal abnormalities . The test is also used as a tumor marker to help detect and diagnose cancers of the liver, testes, and ovaries. The AFP is often ordered to monitor people with chronic liver diseases because of an increased risk of developing liver cancer. ...Read more

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Could surgery cause a tumor marker to be elevated? I had diep surgery on december 12. Blood work taken a week ago showed slightly elevated marker.

Slightly?: Tumor markers that are "slightly elevated" usually mean nothing. Reference ranges are set so that several percent of healthy folks fall outside on either end. ...Read more

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On avastin (bevacizumab) for ov cancer. Could there be a spike in ca125 because tumors are shrinking/dying and spilling their content into blood stream?

Yes, it is possible: Ca 125 is a tumor marker which helps to make decisions about response or lack of it. But it takes 2-3 serial values to decide if the tumor is getting better or worse; one reading does not help as it can be rising both from tumor getting worse or getting smaller and releasing tumor chemicals, which is what ca 125 is. It takes 2-3 mos to be able to get a clear picture. Also watch other tumor aspects. ...Read more

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What can you tell me about the tumor markers test ca15-3?

Breast marker: Ca 15.3 is a serum marker that was once employed in identifying breast cancer. The prefix Ca referred to carbohydrate antigen, a marker not specific for an immunogenic protein in breast cancer but rather one seen with malignant and inflammatory processes in the breast. Its accuracy as with all Ca markers is around 60% and was never approved for diagnosis but rather than for monitoring a response ...Read more

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Can avastin (bevacizumab) cause an increase of tumor markers?

Can avastin (bevacizumab) cause an increase of tumor markers?

Bevasizumab or: Avastin (bevacizumab) vies with vascular endothelial growth factor. It's action interferes with development or growth of blood vessels needed by tumors. Causes incresed blood pressure and bleeding as leading toxicity. No obvious reason that it should influence tumor markers. ...Read more

Neoplasms (Definition)

"tumor" literally translates as "mass", so even a fresh bruise could be called a "tumor". Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. These may be benign or malignant; "malignant" = cancer. In everyday usage, we use "tumor" ...Read more


Tumor Marker (Definition)

Example may be alpha-fetoprotein in testis. If it is there at diagnosis, and disappears, it is a reliable indicator of the tumor, and the tumor return may be heralded in a rise in the marker. Many others, cea, ca 125, ca ...Read more