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Doctor insights on: What Causes Elevated Creatinine Kinase

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What causes elevated bun/creatinine ratio?

What causes  elevated bun/creatinine ratio?

Many causes: Blood tests called BUN (blood urea nitrogen) and cr (creatinine) are often checked to help evaluate kidney function. The normal bun/cr ration is about 10:1 to 15:1. Some of the more common causes of an elevated bun/cr ratio are: dehydration, GI bleeding, increased protein intake, small amount of muscle mass, increased muscle breakdown. ...Read more

Dr. Madhu Kandarpa
2,219 doctors shared insights

Creatinine (Definition)

Creatinine is a byproduct of creatine phosphate, which is present in muscles. Creatinine levels increase if the ...Read more


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What causes elevated bun/creatinine ratio?

What causes elevated bun/creatinine ratio?

Decrease in flow.: Bun=blood urea nitrogen, byproduct of proteins ingested, if rise to high levels due to kidney problem, can cause toxic affects on the body. Creatinine= measurement of renal function. Normal bun/cr ratio about 10. The higher that ratio, the more likely it is not intrinsic kidney disease per se, but reduction in blood flow or volume to kidney, like when on strong diuretic-prerenal-reversible. ...Read more

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What causes an elevated bun/creatinine ratio?

Decrease in flow.: Bun=blood urea nitrogen, byproduct of proteins ingested, if rise to high levels due to kidney problem, can cause toxic affects on the body. Creatinine= measurement of renal function. Normal bun/cr ratio about 10. The higher that ratio, the more likely it is not intrinsic kidney disease per se, but reduction in blood flow or volume to kidney, like when on strong diuretic-prerenal-reversible. ...Read more

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What could increased creatine kinase and aldolase levels indicate?

What could increased creatine kinase and aldolase levels indicate?

Likely muscle injury: Creatine kinase and aldolase would both be elevated after a muscle injury. Ck can also be elevated in kidney failure. Adolase can be sub-classified into a, b and c which helps differentiate from which tissue the high levels came. ...Read more

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What could cause an elevated creatine kinase test?

What could cause an elevated creatine kinase test?

Muscle injury: Creatinine kinase is released from injured or dead muscle cells, be those skeletal, cardiac of smooth muscle cells. Renal failure is also associtated with modestly elevated levels. ...Read more

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Elevated creatinine serum what is critical?

Elevated creatinine serum what is critical?

Diagnosis needed: Serum creatinine is affected by protein intake, gender, age, race, muscular build, and renal function. A rising creatinine is always of concern. "normal" on lab tests is generally less than 1.2 mg/dl. Renal function can be estimated with a more complex formula or measured with a 24 h urine collection. See your internist for further evaluation. ...Read more

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What means bun/creatinine ratio and elevated alt?

What means bun/creatinine ratio and elevated alt?

Renal and liver test: Alt-liver enzyme-c priors. Bun=blood urea nitrogen, byproduct of proteins ingested, if rise to high levels due to kidney problem, can cause toxic affects on the body. Creatinine= measurement of renal function. Normal bun/cr ratio about 10. The higher that ratio, the more likely it is not kidney disease per se, but reduction in blood flow or volume to kidney, like when on strong diuretic-prerenal. ...Read more

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Elevated total creatine kinase with normal isoenzymes. What does this mean?

Elevated total creatine kinase with normal isoenzymes. What does this mean?

CPK: Ck is a polycomponent muscle enzyme. The ck mb is the muscle-brain part of ck total. That is why the lower value for mb. The lab normals would tell whether these are elevated or not. Elevations are usually from muscle damage and the mb is found in heart. ...Read more

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What causes creatinine kinase levels to rise with muscle weakness?

What causes creatinine kinase levels to rise with muscle weakness?

Damage to muscle: The correct term is creatine kinase (ck). Creatinine is something else. Useful to know: most "muscle" weakness is actually caused by nerve, not muscle, malfunction. True muscle weakess: myocytes (muscle cells) contain lots of the enzyme ck. Low levels are found in blood normally. Damage to myocyte cell membranes from a variety of causes causes leakage of ck into the blood. Recovery->normalization. ...Read more

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What can elevated ck levels indicate?

What can elevated ck levels indicate?

Exercise: It's a non-specific test - any muscular work will elevate it. ...Read more

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What causes marked bun elevation with normal creatinine?

What causes marked bun elevation with normal creatinine?

Co-tango usually: The BUN is usually 10 times the creatinine. When the creatinine goes up, the BUN goes up similarly to roughly keep this proportion, in most kidney disease states. The notable exception is when the creatinine goes up say by 20% to 1.2, but the BUN goes up *5 to 50. This strongly suggests a pre-renal state, commonly dehydration. Mild elevations of BUN with normal creatinines aren't of concern. ...Read more

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What causes "elevated liver enzymes"?

What causes "elevated liver enzymes"?

Too Many: There are simply a multitude of causes that can cause "elevated liver enzymes". Seek professional advice from a gastroenterologist or "liver specialist". ...Read more

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What could cause elevated sgot, sgpt and ggt?

What could cause elevated sgot, sgpt and ggt?

Many thngs: Can be gall bladder, liver or pancreatic problems. With out further imaging or work up its hard to say what is the cause. ...Read more

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Low creatinine and elevated bun/creatinine ratio. Please explain?

Decrease in flow.: Bun=blood urea nitrogen, byproduct of proteins ingested, if rise to high levels due to kidney problem, can cause toxic affects on the body. Creatinine= measurement of renal function. Normal bun/cr ratio about 10. The higher that ratio, the more likely it is not intrinsic kidney disease per se, but reduction in blood flow or volume to kidney, like when on strong diuretic-prerenal-reversible. ...Read more

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What causes heart damage or elevated troponin levels?

Few things: Troponin is a marker of several heart disorder including heart attack. Other cardiac conditions such as inflammation of the heart muscle, inflammation of the sac around the heart (pericardoum) also can cause troponin release in the blood. Troponin is increased in cardiac contusion, defibrillation of the heart and some cardiac procedures. It is positive up to 10-14 days after the injury. ...Read more

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What causes high bilirubin?

What causes high bilirubin?

Liver disease: Obstruction of the biliary tract rbc destruction drug and others. ...Read more

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What causes an elevated bun/creatinine ratio on your lab results?

Dehydration: Is most common cause of high BUN with normal creatinine (therefore high ratio). Other causes can be high protein load in the diet, muscle injury or muscle breakdown (bun is formed by the breakdown of proteins). Whether to worry depends on how high the BUN is, and the circumstances when the test was drawn. Talk to the doctor who ordered the test for personalized interpretation. ...Read more

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Alanine transaminase levels of 48 what does this mean?

Depends: Depends on the normal values. Different labs have different ranges for what is considered normal and abnormal. You will need to give us those values. ...Read more

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Are creatinine kinase levels elevated during weight lifting?

Yes: Creatinine kinase can be high after a vigorous exercise routine. Maintaining good hydration is important to clear it from the body. ...Read more

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What causes creatinine kinase levels to rise with muscle weakness?

Damage to muscle: The correct term is creatine kinase (ck). Creatinine is something else. Useful to know: most "muscle" weakness is actually caused by nerve, not muscle, malfunction. True muscle weakess: myocytes (muscle cells) contain lots of the enzyme ck. Low levels are found in blood normally. Damage to myocyte cell membranes from a variety of causes causes leakage of ck into the blood. Recovery->normalization. ...Read more

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I have a blood value for creatinine kinase of 298 u/l. Is that unhealthy or is it normal when doing workouts a few times a week?

Creatinine kinase: This is okay as long as you don't have severe pain. Ck is considered significant when the value is 10 times upper limit of normal. ...Read more

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Creatine kinase vs creatinine, is there a difference between them?

Yes: Creatine kinase is a muscle enzyme that is measured to assess heart damage (the mb isoenzyme form) or skeletal muscle damage (the mm isoenzyme). Creatinine is an endogenous peptide, present in everyone, that is cleared by the kidneys and is measured in clinical practice to estimate kidney function. ...Read more

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Bun is 28, creatinine 1.16. Egfr 61. Healthy 35 yr old caucasian female. Only problem is benign fasciculations x1 year. Normal creat kinase. Why?

Stop worrying: I am going to assume that you feel well and are asking why your estimated GFR is lowish and your BUN a bit high. I like to eat protein and my BUN is always high. Are you athletic? When i was lifting daily my creatinine was 1.6-1.7; or a Motrin tablet or minimal kidney disease may be raising yours. I suggest repeat in a year and stop fretting over a number in the meantime. ...Read more

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Collar bone pain, swelling. X-ray, CT scan nl. Labs for sed rate, cpk, creatinine kinase, CBC all nl. Pcp, pain dr stumped. Any ideas or suggestions?

Collar bone pain, swelling. X-ray, CT scan nl. Labs for sed rate, cpk, creatinine kinase, CBC  all nl. Pcp, pain dr stumped. Any ideas or suggestions?

Do you lift weights?: If you lift weights (benchpress), that might be the culprit. The muscles and ligaments that attach to the collarbone are shown in the diagram. If your pain is at one of these places, you likely have a strain from lifting. If you've fallen on your outstretched arm, the same thing can happen. Also, ask your doctor about osteonecrosis (dying bone due to lack of blood supply). Hope that helps! ...Read more

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What could cause an elevated creatine kinase test?

Muscle injury: Creatinine kinase is released from injured or dead muscle cells, be those skeletal, cardiac of smooth muscle cells. Renal failure is also associtated with modestly elevated levels. ...Read more

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What does it mena to have an elevated total creatine kinase?

What does it mena to have an elevated total creatine kinase?

CPK: Ck is a polycomponent muscle enzyme. The ck mb is the muscle-brain part of ck total. That is why the lower value for mb. The lab normals would tell whether these are elevated or not. Elevations are usually from muscle damage and the mb is found in heart. ...Read more

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What can be the cause of low serum creatine kinase? level is 26 iu/L?

What can be the cause of low serum creatine kinase? level is 26 iu/L?

Means nothing: Reference ranges are set so that several percent of healthies fall outside on either end. Stop worrying. Ask your physician about what kind of aerobic fitness would be right for you. ...Read more

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Elevated total creatine kinase with normal isoenzymes. What does this mean?

CPK: Ck is a polycomponent muscle enzyme. The ck mb is the muscle-brain part of ck total. That is why the lower value for mb. The lab normals would tell whether these are elevated or not. Elevations are usually from muscle damage and the mb is found in heart. ...Read more

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Is creatine Kinase typically elevated in ALS patients?

Is creatine Kinase typically elevated in ALS patients?

Below: Serum creatine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U/liter and a range of 59-1,327 U/liter (male normal less than 95 U/liter, female normal less than 59 U/liter). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as hav ...Read more

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How long would creatine kinase (ck) levels in blood be elevated after exercise?

How long would creatine kinase (ck) levels in blood be elevated after exercise?

Up to four days: Strenuous exercise frequently triggers a rise in ck that peaks 16 to 24 hours following a workout, then stays elevated for 72 hours before falling back to. ...Read more

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What is the relationship btw elevated creatine kinase, sertraline, and working out?

What is the relationship btw elevated creatine kinase, sertraline, and working out?

May be cause/effect.: Unlikely for sertraline to affect muscle directly, but exercise, especially weight lifting can clearly result in slight elevation of muscle enzymes, and not fully clear from your description extent of elevation or your approach to exercise. These are not uncommon issues, and typically are of little consequence. But if you are also losing strength and stamina, consider changing your meds. ...Read more

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Would troponin, Creatine kinase and/or CK-MB be elevated with myocarditis and pericarditis?

Would troponin, Creatine kinase and/or CK-MB be elevated with myocarditis and pericarditis?

Yes: The level of rise would depend on the amount of damage to the myocardial cells. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more

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Can you donate blood if you have a metabolic myopathy and elevated creatine kinase?

Can you donate blood if you have a metabolic myopathy and elevated creatine kinase?

If you are otherwise: fit. An elevated creatine kinase, per se, is not contraindication to blood donation. However, there are a number of other screening issues that need to be satisfied before you may donate blood. I applaud your devotion to civic duty. Consult this site for more info (scroll down to see the questionnaire). ...Read more

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How long does it take for creatin kinase levels to go down?

How long does it take for creatin kinase levels to go down?

Depends on cause : CPK levels are elevated due to injury to the muscles, it gets elevated with myocardial injury during heart attack and injury to the sleletal muscles as well.So it depends how much damage to the muscles is and the cause of the damage and responce to treatment of the underlying condition it can take from few days to several days. ...Read more