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What Causes Acute Leukemia
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Leukemia cause: We don't know for sure. Leukemia develops as the consequence of a series of genetic changes in blood cell offsprings. These changes alter normal growth and differentiation of the cells, resulting in an accumulation of abnormal, immature blood cells in the bone marrow and peripheral blood. Exposure to chemicals, radiation, tobacco, or chemotherapy, infection, etc have been associated with leukemia. ...Read moreSee 1 more doctor answer
Causes of leukemia: The exact causes of leukemia remain unclear. There are risk factors known to increase the risk of some types of leukemia: 1) exposure to ionizing radiation 2) exposure to environmental toxins, such as benzene and some petrochemicals 3) history of previous chemotherapy treatment for cancer (especially with use of alkylating agents) 4) down syndrome 5) genetic predisposition (single gene or multiple. ...Read more
AML: Acute myelogenous leukemia (AML) is a type of leukemia that usually present relatively rapidly, but in some cases may have a longer development phase. It may be preceded by mds. Treatment is often stratified by age and co-morbidities but can include intensive chemotherapies and allogeneic stem cell transplant. ...Read moreSee 1 more doctor answer
Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. ...Read moreSee 1 more doctor answer
A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read moreSee 1 more doctor answer
Marrow malignancy: AML is a bone marrow malignancy characterized by uncontrolled growth of leukemic cells in the bone marrow. It leads to very high white blood cell counts, anemia and thrombocytopenia (low platelets). It is rapidly fatal without prompt diagnosis and treatment. It can be cured in up to about 40% of people. ...Read more
Marrow cancer: CML is a marrow malignancy characterized by excessive number of white blood cells with various degrees of maturation. Most CML patients have deficient number of red cells and platelets. CML responds dramatically to oral agents called tyrosine kinase inhibitors. Examples are Gleevec and Sprycel (dasatinib). ...Read more
Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read moreSee 1 more doctor answer
It involves Chemothe: Typical treatment for acute leukemia requires admission to the hospital for chemotherapy which can make you sick and cause infections. So, most patients end up in the hospital for several weeks to begin with till their leukemia goe sinto a remission which is early benefit of an effective chemotherpy which is the case in half to 2/3 of the cases. Young adults do much better than the old(>60 yrs). ...Read more
Bcr-abl: CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. ...Read more
Blood cancer: All is a form of leukemia which in turn is a form of cancer, more specifically blood and bone marrow cancer. The word "acute" means it progresses faster, as opposed to chronic cases that usually have a slower progression. The word "lymphoblastic" means immature lymphoid and describes the type of malignant cell involved in this leukemia, as opposed to other types of cells, for example myeloid. ...Read moreSee 3 more doctor answers
Mostly unknown: Cll affects older white men more that other parts of the population and the cause is unknown in most cases. Exposure to certain herbicides and insecticides, including agent orange used during the vietnam war, have been linked to an increased risk. For more information consult: http://www.Mayoclinic.Com/health/chronic-lymphocytic-leukemia/ds00565/dsection=risk. ...Read more
White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people. ...Read moreSee 1 more doctor answer
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