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Doctor insights on: What Can Be Done To Prevent Renal Failure Or Derangements In Myeloma Patients

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What can be done to prevent renal failure or derangements in myeloma patients?

What can be done to prevent renal failure or derangements in myeloma patients?

Disease treatment: The only effective prevention for the renal disease associated with myeloma is the effective treatment of the underlying disease. ...Read more

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Dr. Qamar Khan
118 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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How common is renal failure in myeloma patients?

How common is renal failure in myeloma patients?

30% dx; 50% life: Around 30% at diagnosis and about 50% throughout disease course. However, this may be less given newer anti-myeloma agents (?). ...Read more

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What is the current prognosis of african american women with multiple myeloma with renal failure?

What is the current prognosis of african american women with multiple myeloma with renal failure?

Depends: This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib). ...Read more

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My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?

My brother (51) is in the final stages of multiple myeloma and was told he will die of  kidney failure. Blood tranfusions weekly. Timeline estimate?

Get extra support: Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. ...Read more

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Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more

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What percentage of patients with multiple myeloma will survive?

It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more

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How does anti dkk1 treatments work on multiple myeloma patients?

In research: This antibody can change the activity of bone cells that are affected by myeloma cells. It is in early clinical trials and I am not sure how long it will take for larger trials to take place. ...Read more

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What are some of the side-effects of velcade (bortezomib) when treating myeloma patients.

What are some of the side-effects of velcade (bortezomib) when treating myeloma patients.

Quite a few: 1. Velcade (bortezomib) can affect nerves. It mainly manifests as numbness an pain in hands and feet. Risk increased with prolonged use and when using the drug twice a week. Risk can be decreased by using it subcutaneously ( instead of in a vein) and using it once a week. 2. Many patients report diarrhea on velcade (bortezomib). 3. Velcade (bortezomib) can cause blood counts to go down. ...Read more

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Why Blinding bright white light in the mrngs and shakey vision and not focused for 5 to 7 mins. Cant see. Pupils very small? Multiple Myeloma patient

See an eye doctor.: You need to see an ophthalmologist right away. This may not be related to myeloma, but there are eye problems related to myeloma that could lead to retinal hemorrhage and blindness. Good luck. ...Read more

Dr. Tarek Naguib
587 doctors shared insights

Kidney Failure (Definition)

The kidneys do several tasks. Dialysis is necessary when one or more of the following occur, that can't be remedied or palliated with medications: 1. Insufficient clearance of daily toxins in food and metabolic waste 2. Insufficient clearance of excess water 3. Dangerous electrolyte imbalance, ...Read more