Doctor insights on:
What Are The Systems Of Ms
Very complicated: Latest info suggests an inborn genetic susceptibility with environmental triggering events. The basic pathology causes the immune system to mistake brain and spinal cord myelin as a foreign entity. Data regarding grey matter involvement is starting to explain much of what is occurring. All current meds target lymphocyte trafficking, (t cells), but the b cell research is exciting. ...Read more
Immune mediated: Inflammatory disease of brain, spinal cord, and eye, occurring in genetically susceptible people in their late 20's into 30's, when risk factors such as living at northern latitudes, smoking, prior viral infections, adolescent obesity, trigger onset of initial attacks. It involves exclusively attacks on nerve coverings within the central nervous system. Treatment is very effective in 2015. ...Read more
SEE BELOW: Lupus may mimic ms and in evaluating a patient for ms, we commonly check lupus blood tests to make certain. But in general, this is a collagen vascular disease involving several organs in the periphery, not just brain or spinal cord, while ms is restricted to the central nervous system. ...Read more
Deceptive likeness: Both lupus and ms are autoimmune disorders and both affect the central nervous system. Both causes apparently random, sudden and often bizarre symptoms. Treatments for ms long-term have now been primarily interferon-based. No such widely accepted treatment exists for lupus. Steroids are often helpful in both conditions in short term. Diagnostic tests can separate the 2 conditions often. ...Read more
Is lupus attacking the nerves the same as ms? I know they’re different diseases, but when lupus affects the nervous system, does it do it the same way as ms? Are the symptoms the same?
One kind of lupus:
Lupus has many ways of hurting and destroying organs, one kind of lupus of the nervous system is similar and may coincide with ms
numbness poor function disconections of short circuits in electric system (nerves are like cables, with ms you loose the insulation, myelin). ...Read more
Does not cause: Ms doesn't directly cause any type of heart disease, and the only effect on the heart might be the slowing of the pulse within the first six hours after taking the oral medicine gilenya, (fingolimod) which does not persist. ...Read more
For a yearthey have been sayingi have possible ms. Nowtheh say I must have had a virus and it has attacked mynervous system will steroids help?
Yes & no:
Steroids are helpful for a condition called acute disseminated encephalomyelitis (ADEM) which is possibly due to a viral infection. This is a short-term, aggressive condition, not a long-term condition, and steroids are normally used in the early stages.
In MS, steroids are used during severe attacks.
If your symptoms are like these examples, steroids may help. ...Read more
I see in MS & gbs the immune system only seems to attack the mylein sheath. What stops the immune system going further & directly attacking the nerves?
Variable: Yes, in many cases, the myelin sheath alone is involved, and the underlying axon is spared, BUT immune systems are variable, and the more aggressive forms of MS and GBS can result in axonal damage. It is the body's ability to turn off the immune attack which quells the ultimate damage. ...Read more
What are some of the best ways to get over colds? I have MS and they hit me hard. Immune system is compromised from my Ocrevus treatment killing Bcels
I would like to see another neurologist for my ms. Would like to compare as I have only been to one. Recommendation? I have not had any recurring systems since the first diagnosis (2005) other than tiredness and occasional dizziness.
Second opinion: Glad you have been stable. But have your MRI's confirmed lack of new lesions, or absence of brain atrophy? Has your MS medication been without side effects or difficulties with compliance? Has your fatigue been successfully controlled? If no to any of the above, get a second opinion. ...Read more
I have a very weak immune system and my MS treatment makes it worse. Will wearing masks around sick people keep me safe?
Will help but it is wise to try to avoid such contact as much as possible...people should understand... (family and friends especially) and you should avoid crowds especially during a FLU season such as the one we have now!
Hope this helps!
Dr Z ...Read more
Can myelin injection treat MS, since the immune system is attacking myelin sheeth adding myelin in blood will keep WBC away from the nerves, right?
Wrong: This simply doesn't work. It's simplistic and in fact, you're asking for making the body more sensitive. Your body also makes attacking white cells to order when confortonted with something that it's sensitized to. Tolerization procedures exists for some autoimmune diseases and the whole are is fascinating. ...Read more
Taking copaxone (glatiramer) for many years for my MS. I have pain in my right big toe with inflamation. Could my body systems not want me to take it. ... Gout?
Need to reassess: At your current age, 77, you may no longer need copaxone, (glatiramer) and if you developed a secondary progressive ms transition, this drug would not be appropriate to handle that either. The pain in your toe could be gout, but other explanations may be considered. Yes, check your uric acid, but also update MRI of brain, and get full neurological re-evaluation. ...Read more
Severe sensitivity in toes/feet. Light touch causes bad pain. Dr mentioned autonomic nervous system problems? Ms related to system? Ms reason for pain?
I had a cat scan, showed chronic microvascular ischemic white matter disease. My doctor who ordered the CT looked at it and did not comment. Is MS or other auto immune system possible?
What is ms?
Multiple sclerosis: Ms is a disease of the brain & spinal cord in which inflammation damages fatty tissue called myelin that surrounds certain nerve cells in the brain and spinal cord. The "myelin" acts like insulation around an electric wire. When its damaged nerve cells can not send messages to other parts of the nervous system normally. This can result various symptoms, weakness, speech or vision issues, etc. ...Read more
Who gets ms?
Who gets MS: People everywhere may develop multiple sclerosis. It most often starts between ages 20-40. Cases of teenagers and older adults are less common. It is more common in climates that are cold, cloudy, and located in far northern or far southern latitudes. Family history and smoking are related to MS, but are not the cause. MS is relatively rare, it is present in only 2 million people worldwide ...Read more
Yes. But low. .:
Even in identical twins, the incidence is only 20-35%, thus environmental factors (infections such as epstein virus, geography, vitamin d deficiency? +others factors, unknown) play more important role than genetic in development of ms. There is still much ongoing research in this area and hopefully will shed more light in the years ahead.
It is a difficult one if you have ms, best of luck to you. ...Read more
Benign MS: About 15% of people with MS have only 1-2 attacks of neurological deficit, otherwise, they have an entirely normal life. This is the case even if they are not treated for MS. It would be nice to know how to predict who will have such a clinical course. ...Read more
Process: History and physical exam suggests the diagnosis. MRI films demonstrating old and new lesions together, scattered about the brain white matter, can be confirmatory, and lesions in both brain and spinal cord can clinch the diagnosis. Spinal fluid often useful if the films are ambiguous, and blood studies are obtained to exclude other disorders which may mimic MS. ...Read more
Acute vs chronic: New symptoms (acute) imply a new attack on the nervous system by the disease. These usually improve with time but the patient will often not fully recover. Chronic symptoms are due to structural damage that will not improve over time. ...Read more
Aubagio was just released for the treatment of relapsing-remitting multiple sclerosis. Bg-12 (oral fumarate) should be available before mid year. Both are oral drugs which will be added to the only other oral drug- gilenya (fingolimod).
There are several other drugs which will be added within the next few years proving that there is reason to be optimistic about the future of ms treatment. ...Read more
Benign MS occurs in about 15% of people with relapsing remitting MS. It means a person has 1-2 attacks of MS symptoms and no other symptoms the rest of their life.
We cannot determine who has or does not have this form of MS, but it would be nice to be able to determine this. ...Read more
Multiple Sclerosis: For doctors, ms usually means multiple sclerosis, a disease that affects the brain and spinal cord, resulting in loss of muscle control, vision, balance, and sensation (results in numbness or paresthesia). With multiple sclerosis, the nerves of the brain and spinal cord are damaged by one's own immune system, so ms is called an autoimmune disease. ...Read more