Doctor insights on:
What Are The Effects Of Methotrexate And Coumadin
Many and quite safe!: Mtx is used in many autoimmune diseases with great effect. The drug is given IV in high doses to treat cancer. In much lower doses, given subcutaneously like insulin, with fewer side-effects than the same oral dose, does not go to the liver. And you absorb 100%, not the 40-90% when taken by mouth. Great drug. Ist line in ra! ...Read moreSee 1 more doctor answer
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Most anything.: Greens ( spinich, kale, mustard, turnip greens) can blunt the effect on the coumdain on thinning your blood. The important thing is, if you eat certain foods reguarly, you will not have wild swings on your pt. If you suddenly binge on foods such as these, that is a different story. And the taking of antibiotics can increase your pt. ...Read moreSee 1 more doctor answer
Several.: Fatigue after taking your weekly dose. Gi quiziness. Hair loss. Potential liver issues, especially taken orally. Your white count can be lowered, as well as hemoglobin. Everyone on mtx should take folic acid. Monitoring for side effects (benefits too) should take place every three months or sooner. ...Read moreSee 1 more doctor answer
For dose 6 of methotrexate for ctd, my dose is increased. I take on tues but concern w/ side effects & work.Okay to take 4 days early (sat from now on)? My rhemd said okay 2switch to a day that works.
Can going from 22.5mg of methotrexate injections to 25mg (in a 6year old) increase your chance of side effects? So if didn't have before can have now?
Yes, definitely: A weekly dose of 22.5mg of Methotrexate injections is already a pretty high dose for a 6yo child, so i would not go up further. I would reduce it to 12.5 or 15mg of Methotrexate weekly injections and add either Enbrel (less painful) or humira(equally effective and better for eye inflammation and ibd-related arthritis).Talk to your rheumatologist about it.Biologics are very safe with fewer side efx. ...Read moreSee 1 more doctor answer
Bleeding. : This medication can cause serious bleeding if it affects your blood clotting proteins too much (shown by unusually high inr lab results). Even if your doctor stops your medication, this risk of bleeding can continue for up to a week. Tell your doctor right away if you have any signs of serious bleeding, including: unusual pain/swelling/discomfort/easy bruising, prolonged bleeding from cuts. ...Read moreSee 1 more doctor answer
Not really: The major side effect of Coumadin is bleeding from too much or getting another blood clot from too little. As long as your inr is between 2-3 and stays that way, you risk of bleeding or further clotting should not change--no matter how long you take it. Once you are off of Coumadin for 5 days or less, its effects should be gone, as dr. Penba said. ...Read moreSee 1 more doctor answer
Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more
Nausea, hair loss,: There are many described that can be lessened by also taken folic acid. the things we look for are many including nausea - sometimes called ucks, hair loss, mouth sore, low blood counts, liver changes, Rare one, include lung problems and a type of lymphoma. You need to discuss this with your physician and help monitor you and reduce these risks. ...Read more
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