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Doctor insights on: What Are The Differences Between Bone Marrow Biopsy And Chromosome Analysis

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What are the differences between bone marrow biopsy and chromosome analysis?

What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

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Dr. Pen Hou
117 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


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What are the differences between a bone marrow biopsy and aspiration?

What are the differences between a bone marrow biopsy and aspiration?

Nothing...: They are literally one and the same... The aspiration is the procedure... And then the pathologist looks at the sample as a biopsy specimen. ...Read more

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How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

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What is the difference between bone marrow aspiration n bone marrow biopsy what tests are performed in both?

More info: A bone marrow aspirate is just drawing bone marrow into a syringe for evaluation. A biopsy actually removes a core of bone from the marrow cavity to check for architecture of the marrow. ...Read more

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What are the differences between trisomy 21 and xxx?

What are the differences between trisomy 21 and xxx?

Completely different: Down syndrome (trisomy 21) is characterized by varying degrees of neurodevelopmental delay (mild to severe) propensity for dementia at early age and heart/blood disorders, but may have a near normal life span. Extra chromosome x is usually very mild condition; affected females tend to be tall and have relatively small heads and minimal decrease in their verbal and performance iq scores. ...Read more

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What are the risks for donors and how is bone marrow collected?

What are the risks for donors and how is bone marrow collected?

Infection and pain: This is a relatively safe procedure but the marrow is harvested by taking a small amount from your hip bone. You lie on your stomach, the skin' muscle overlying the hip bone is anesthetized and cleaned. A needle is then inserted into the bone and gently rotated until it is deep enough to get to the marrow. A small amount is drawn out and the needle is removed. It is an outpatient procedure. ...Read more

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What are the cellular and molecular aspects of Paget's disease of bone ?

What are the cellular and molecular aspects of Paget's disease of bone ?

The answer: is too extensive for 400 words or less, but try this link: http://www.orthochirurg.com/resources/journals/JAAOS/Volume3/V3N6A4.pdf ...Read more

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Can there be different opinion on beta 2 microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Can there be different opinion on beta 2 
microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Beta 2 Microglobulin: Is a way of following myeloma response to therapy. The problem is that it can be elevated in other conditions- including benign ones. I've seen it very high in patients with kidney dysfunction. So the leel could be different than the bone marrow, which is the only real way to prove multiple myeloma. ...Read more

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What are the benefits of a blood and bone marrow transplant?

What are the benefits of a blood and bone marrow transplant?

Cure diseases: A bmt or stem cell transplant replaces a patient's bone marrow with that of someone else (allogeneic transplant) or by a patient's own marrow as a rescue from very high dose chemotherapy. With allogeneic transplant for cancers, the new bone marrow can attack and destroy cancer cells that it recognizes as bad, even though the patient's immune system failed to do that. ...Read more

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Is there a relation between polyclonal spike n increased plasma cells in the bone marrow pls answer?

Is there a relation between polyclonal spike n increased plasma cells in the bone marrow pls answer?

Relevance?: is there any relevance to any illness? Whenever there is polyclonal spike in the activity of the bone marrow, all cell types may increase in number. Plasma cells are related with B lymphocytes with more complex origination and maturation pattern involving lymphoreticular system. ...Read more

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How does one differentiate between infection n malignancy in the bone marrow plasma cell percentage?

Monoclonal or not: Malignant plasma cells are monoclonal in that they are copies of each other and produce the same antibody. This antibody can be identified in urine or blood tests in malignancy. Increased plasma cells due to infection are polyclonal (not copies of each other) and produce non-identical antibodies. ...Read more

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After what figure of plasma cells in the bone marrow does it affects the cbc?

After what figure of plasma cells in the bone marrow does it affects the cbc?

Multiple myeloma: Over 10% of plasma cell in the bone marrow may show mild anemia. However diagnosis of multiple myeloma is based on the presence of monoclonal protein in the serum and urine along with Plasmacytosis .myeloma affects the bone marrow , bones and kidneys. Screening measures for myeloma not beneficial. As disease advances, plasma cells may show in the peripheral blood. ...Read more

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What are the chances of no complications from bone marrow biopsy?

What are the chances of no complications from bone marrow biopsy?

Low complication : The potential complications from bone marrow biopsy include bleeding and infection. A physician who does the procedure often will have, usually, a low complication rate. In general the rate should be very low (my guess is less than 1%). Remember, the procedure gives information not otherwise obtainable. Discuss with you physician and if you need it- go for it. ...Read more

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Dr what is the difference between mds and dysmyelopoiesis are they both cancer?

Dr what is the difference between mds and dysmyelopoiesis are they both cancer?

Bone marrow disorder: MDS is a well defined condition(although there are several different types of MDS). MDS leads to an abnormal CBC affecting Red cells(low Hemoglobin), low WBC/ANC and low platelet counts. Dysmyelopoiesis is more non specific...it may or may not affect the peripheral blood(CBC). Tell us the results of your CBC(complete Blood count) and then we can help you arrive at a diagnosis. ...Read more

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What is the process involved for carcinoid tumours and bone marrow donation?

Not clear?: Please be more exact in asking what you want to know. ...Read more

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My fna of thyroid revealed groups of epithelial cells in macrofollicular patterns. Are these bad/pre-cancer cells? What should follow up treatment be?

My fna of thyroid revealed groups of epithelial cells in macrofollicular patterns. Are these bad/pre-cancer cells? What should follow up treatment be?

Ask your doctor.: Epithelial cells in macrofollicular patterns are usually benign thyroid cells and are usually not associated with a premalignant or malignant process. This is good news. Ask the doctor who ordered the fna to help you interpret the report and to answer your questions. That person will be able to give you information in the context of your personal clinical setting. ...Read more

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How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years. ...Read more

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What is the difference between a bone marrow transplant and a stem cell transplant?

What is the difference between a bone marrow transplant and a stem cell transplant?

Source of the cells: The terms are often used interchangeably. In a bone marrow transplant the cells are taken from the bone marrow. For a stem cell transplant the cells are taken from the blood. ...Read more

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Dr. James Lin
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more