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Doctor insights on: What Are The Differences Between Bone Marrow Biopsy And Chromosome Analysis

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What are the differences between bone marrow biopsy and chromosome analysis?

What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

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Dr. Pen Hou
106 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


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How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

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Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Yes: Usually, when a bone marrow biopsy/aspirate is done, additional material is collected for special testing, such as flow cytometry and chromosome analysis. While the most important information is obtained by microscopically examining the cells in the bone marrow, the results of those special studies can help the pathologist more specifically diagnose the cancer, if one is present. ...Read more

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I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

I was just told that my bone marrow biopsy showed I have a 3rd set of chromosome 8. I have none of the clinical features. Is it possible the test is ?

Trisomy 8 in marrow: This abnormality is not associated with any specific disease, since patients can have different clinical features, such as leukemia, polycythemia vera, and several other blood disorders. It's been suggested that the trisomy may be a secondary rather than primary event in the development of the disease. It's different than trisomy 8 as a primary genetic event-w/ fetal development problem etc. ...Read more

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What are the differences between a bone marrow biopsy and aspiration?

What are the differences between a bone marrow biopsy and aspiration?

Nothing...: They are literally one and the same... The aspiration is the procedure... And then the pathologist looks at the sample as a biopsy specimen. ...Read more

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What is the difference between bone marrow aspiration n bone marrow biopsy what tests are performed in both?

More info: A bone marrow aspirate is just drawing bone marrow into a syringe for evaluation. A biopsy actually removes a core of bone from the marrow cavity to check for architecture of the marrow. ...Read more

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Where on the body is a bone marrow biopsy done?

Where on the body is a bone marrow biopsy done?

The hip: Biopsies are taken from the upper back portion of the hip. Occasionally, if a suction aspiration is needed, a breastbone puncture can be used. ...Read more

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Does getting a bone marrow biopsy typically hurt?

Depends: If your receive conscious sedation, you will not have noticeable pain during the procedure. Afterward, you may have pain for a day or so unless there is an untoward complication. I had one and it hurt minimally for 24 hours. I had conscious sedation. ...Read more

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How long could the pain last after a bone marrow biopsy?

Short term: Should be no more than a few days; and that is on the longer side of the estimate. ...Read more

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Could a bone marrow biopsy cause me problems later in life ?

No: There are no long term detriments to a bone marrow biopsy. Although rare, an infection is possible but this still should not cause any long term issues. ...Read more

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Dr. Dariush Saghafi
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more