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Doctor insights on: What Are The Differences Between A Bone Marrow Biopsy And Aspiration

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What are the differences between a bone marrow biopsy and aspiration?

What are the differences between a bone marrow biopsy and aspiration?

Nothing...: They are literally one and the same... The aspiration is the procedure... And then the pathologist looks at the sample as a biopsy specimen. ...Read more

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Dr. Pen Hou
106 doctors shared insights

Bone Marrow Biopsy (Definition)

A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more


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What is the difference between bone marrow aspiration n bone marrow biopsy what tests are performed in both?

More info: A bone marrow aspirate is just drawing bone marrow into a syringe for evaluation. A biopsy actually removes a core of bone from the marrow cavity to check for architecture of the marrow. ...Read more

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What tests should be done frm bone marrow biopsy n aspiration slides?

Depends on purpose: How many tests can be done from blood? Millions. How many tests can be done from a bone marrow biopsy (BMB) specimen? Many? What tests should be done? It depends on 1) purpose for performing the BMB and 2) the findings the pathologist sees on morphologic examination of the aspirate & biopsy. Tests may include stains for iron or congo red (amyloidosis) as well as flow cytometry, cytogenetics, FISH. ...Read more

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What does it mean if a bone marrow biopsy/aspiration report shows hypocellular marrow?

What does it mean if a bone marrow biopsy/aspiration report shows hypocellular marrow?

Hypocellular marrow: The normal bone marrow is a mixture of cells and fat. Hypocellular marrow means the marrow has fewer cells in the bone marrow space that is expected for that patient's age. There are many causes for this including nutritional deficiencies, bone marrow failure syndomes, pre-leukemia (myelodysplasia), prior chemotherapy, toxins and medications. ...Read more

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Can you tell me about bone marrow biopsy/aspiration report shows hypocellular marrow?

Can you tell me about  bone marrow biopsy/aspiration report shows hypocellular marrow?

Talk to doctor: This is a complicated issue to address in this forum. You should discuss it with your doctor and the two of you may wish to involve the pathologist who signed out the bone marrow report. ...Read more

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Can any doc tell me what's meant when a bone marrow biopsy/aspiration report shows hypocellular marrow?

Can any doc tell me what's meant when a bone marrow biopsy/aspiration report shows hypocellular marrow?

Bone marrow: Bone marrow cellularity refers to how much of the marrow is making blood cells, and how much is fat. As people age, it tends to decline and move more centrally. Severe hypocellularity may indicate aplastic anemia or even leukemia, which needs treatment. Lesser degrees may or may not, depending on other symptoms and lab findings. ...Read more

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Bone marrow biopsy/aspiration (chronic cytopenias/fatigue) f/u appt delayed 4 karyotyping. Is that usually to check CML or what else is possible? Thx

Bone marrow biopsy/aspiration (chronic cytopenias/fatigue) f/u appt delayed 4 karyotyping. Is that usually to check CML or what else is possible? Thx

Karyotype important: There are many things that cause low counts. CML isn't one of them - that causes high counts. Getting the genetic testing is very important for making an accurate diagnosis no matter what the diagnosis. I always make my patients wait for that before they come in for their follow-up appointment. I know it's hard to wait, but it's better to get the full and accurate picture all at once. ...Read more

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What are the differences between bone marrow biopsy and chromosome analysis?

What are the differences between bone marrow biopsy and chromosome analysis?

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups. A chromosome analysis entails looking at the genes and structure within the nucleus of a cell. They may come from the bone marrow if needed. ...Read more

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Dad was prescribed pyrodixine to treat his moderate anemia after bone marrow biopsy and aspiration done. Dr. Said no cancer. What s diagnosis options?

Dad was prescribed pyrodixine to treat his moderate anemia after bone marrow biopsy and aspiration done. Dr. Said no cancer. What s diagnosis options?

Anemia: Did they tell you the bone marrow findings? I would be interested in iron content of the bone marrow. He could have nutritional anemia Or sideroblastic anemia .. You should discuss this with his hematologist ...Read more

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Is a bone marrow biopsy painful?

Yes and no: Any biopsy will be painful but in the hands of an experienced doctor and proper sedation (local novocaine) it can be a much more tolerable process. Pain killers such as tylenol (acetaminophen) afterwards for 24-58 hours can be a help too. ...Read more

Dr. James Krick
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Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more