Doctor insights on:
What Are The Causes Of Sickle Cell Disease
Inheritance: The sickle cell gene is a mutation in the way the hemoglobin molecule is formed.It takes a pair of sickle genes to cause the change.A single normal gene can cancel the abnormal gene effect. Parents with a single sickle cell gene will be asymptomatic. When a baby gets a sickle gene from both parents, the abnormal genes are expressed as SS disease. ...Read more
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
Genetic disease: Sickle cell disease means the patient inherited the gene for sickle cell disease from both mother and father. The disease is associated with anemia (low blood) and often some degree of jaundice (yellowness.) people with this problem are more likely to be ill with infections early in life and take antibiotics and receive special vaccinations, to help prevent infections. ...Read moreSee 1 more doctor answer
"Undesired Traits": Sickle cell disease is caused by two individuals who both possess sickle cell trait, a condition in which the individuals look normal and do not have the disease, but carry a recessive gene that when combined with a similar person yields sickle cell disease. This condition can be genetically tested prior to having children- especially african americans. ...Read more
Gene mutation: Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation. ...Read more
Gene mutation: Sickle cell disease is caused when an individual inherits two mutated copies (one from each parent) of the beta-hemoglobin gene. The specific dna mutation causes a change from glutamic acid to valine at position 6 within the protein, and this changes the biochemical properties of the beta-hemoglobin chains to cause abnormal polymerization under certain conditions (hypoxia, ph change, etc.). ...Read moreSee 1 more doctor answer
Gene mutation: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin.The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance. This means that both the mother and the father must pass on the defective form of the gene for a child to be affected. ...Read moreSee 1 more doctor answer
Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read moreSee 1 more doctor answer
- Talk to a doctor live online for free
- What are the symptoms of sickle cell disease?
- What are the causes of sickle cell anemia?
- What is the genetic cause of sickle cell anemia?
- Ask a doctor a question free online
- Malaria in sickle cell disease
- Living with sickle cell disease
- Sickle cell thalassemia disease
- Is sickle cell disease curable?
- Talk to a hematologist online for free