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Doctor insights on: What Are The Causes Of Sickle Cell Disease

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What are the causes of sickle cell disease?

What are the causes of sickle cell disease?

Inheritance: The sickle cell gene is a mutation in the way the hemoglobin molecule is formed.It takes a pair of sickle genes to cause the change.A single normal gene can cancel the abnormal gene effect. Parents with a single sickle cell gene will be asymptomatic. When a baby gets a sickle gene from both parents, the abnormal genes are expressed as SS disease. ...Read more

Dr. James Ball
354 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more


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What are the causes of sickle cell disease and what are some characteristics?

What are the causes of sickle cell disease and what are some characteristics?

Genetic disease: Sickle cell disease means the patient inherited the gene for sickle cell disease from both mother and father. The disease is associated with anemia (low blood) and often some degree of jaundice (yellowness.) people with this problem are more likely to be ill with infections early in life and take antibiotics and receive special vaccinations, to help prevent infections. ...Read more

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Blood doctor, i want to know what are the causes of sickle cell disease?

Blood doctor, i want to know what are the causes of sickle cell disease?

"Undesired Traits": Sickle cell disease is caused by two individuals who both possess sickle cell trait, a condition in which the individuals look normal and do not have the disease, but carry a recessive gene that when combined with a similar person yields sickle cell disease. This condition can be genetically tested prior to having children- especially african americans. ...Read more

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What is the cause of sickle cell disease and trait?

What is the cause of sickle cell disease and trait?

Gene mutation: Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation. ...Read more

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Need expert help here. What are the major causes of sickle cell disease?

Need expert help here. What are the major causes of sickle cell disease?

Gene mutation: Sickle cell disease is caused when an individual inherits two mutated copies (one from each parent) of the beta-hemoglobin gene. The specific dna mutation causes a change from glutamic acid to valine at position 6 within the protein, and this changes the biochemical properties of the beta-hemoglobin chains to cause abnormal polymerization under certain conditions (hypoxia, ph change, etc.). ...Read more

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What would you say are major causes of sickle cell disease?

What would you say are major causes of sickle cell disease?

Gene mutation: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin.The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance. This means that both the mother and the father must pass on the defective form of the gene for a child to be affected. ...Read more

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How much time does it take for sickle-cell disease to cause an autosplenectomy?

How much time does it take for sickle-cell disease to cause an autosplenectomy?

Few years: Patients with homozygous sickle cell anemia (Hgb SS) auto-infarct spleens in first few years of life. Patient's with Hgb SC or sickle cell anemia with hereditary persistence of fetal hemoglobin usually maintain some degree of splenic function. ...Read more

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What diseases could cause RBC to start messing up inside of your body (besides sickle cell)?

What diseases could cause RBC to start messing up inside of your body (besides sickle cell)?

Variety: A variety of diseases can cause red cell issues--from size and number of red cells to breakdown of red cells because of a stress, as infection or immune related problems. The later may be associated with bilirubin (yellowness)--in eyes and skin. ...Read more

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How does a genetic mutation cause sickle-cell disease?

How does a genetic mutation cause sickle-cell disease?

Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read more

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How is living with sickle cell anemia/disease?

Depends on the sever: It all depends on what kinds of sickle cell anemia you have and how severe it is. For instance someone with sickle cell trait may have no problems whatsoever. ...Read more

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What are some of the more subtle symptoms of sickle cell anemia disease?

What are some of the more subtle symptoms of sickle cell anemia disease?

Not much: Sickle cell disease is seldom subtle. Patients have intermittent periods of intense pain, often in bone, they have all manifestations of profound anemia, including diminished exercise tolerance, shortness of air, generalized fatigue, etc. This is a very bad disease with few subtle manifestations. ...Read more

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How do 2 people without sickle-cell anemia to have a child with sickle-cell disease?

How do 2 people without sickle-cell anemia to have a child with sickle-cell disease?

Yes: The defect of sickle cell anemia occurs when 2 sickle cell genes are passed to a newborn. Since each parent passes half their genes at conception & it takes 2 sickle genes to cause disease, one gene comes from each parent. Many parents carry this gene quietly, unknown to them because it doesn't make a single gene carrier sick. ...Read more

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How could 2 people without sickle-cell anemia to have a child with sickle-cell disease?

Genetics: Sickle cell disease must be inherited from both parents. Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything. ...Read more

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My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?

My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?

25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read more

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Is it possible to be diagnosed with sickle cell anemia at 43? Even without ever experiencing any symptoms of the disease?

Is it possible to be diagnosed with sickle cell anemia at 43?  Even without ever experiencing any symptoms of the disease?

Possible, but...: Most people will have symptoms of enough severity to be diagnosed before adulthood. That being said, there is variation in the severity of sickle cell disease, most likely due to a number of other genes that modulate the symptoms. Thus, it probable is quite rare, but there could be that individual with a particular genetic makeup that has minimal disease that goes undiagnosed. ...Read more

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Both carriers of sickle cell anemia. What can you tell them about their chances of any child of theirs exhibiting this disease?

Both carriers of sickle cell anemia. What can you tell them about their chances of any child of theirs exhibiting this disease?

In theory 25%: Please remember these statistics apply to large population and therefore it is possible for a couple with sickle cell trait have children with and without sickle cell disease. ...Read more

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If my boyfriend has sickle cell anemia and I don't have neither the trait or disease, will our child end up having it?

If my boyfriend has sickle cell anemia and I don't have neither the trait or disease, will our child end up having it?

No: If your boyfriend has sickle cell anemia (2 abnormal genes) and you have 2 normal genes, then your children will all have sickle cell trait but none will have the disease. You need to be sure you have no other blood abnormalities like thalassemia or hemoglobin c trait which can be totally asymptomatic; this would change the answer significantly! ...Read more

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Does sickle cell nemia has treatment? If so what are the medications? What are the foods that achild with sickle cell anemia eat? Is it tur that when some body reaches the age eighteen the disease disapears

Many questions: Sickle cell anemia is genetic and never disappears without bone marrow transplantation. Sickle cell anemia has medications that improve outcomes. Penicillin prophylaxis, empiric treatment of fever with antibiotics, and Prevnar (pneumococcal vaccine) / Pneumovax immunizations decrease risk of dying from infection. Hydroxyurea can decrease the frequency of painful crises and may minimize / delay sickle cell damage to body ...Read more

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