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Doctor insights on: What Are The Causes Of Sickle Cell Disease

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What are the causes of sickle cell disease?

What are the causes of sickle cell disease?

Inheritance: The sickle cell gene is a mutation in the way the hemoglobin molecule is formed.It takes a pair of sickle genes to cause the change.A single normal gene can cancel the abnormal gene effect. Parents with a single sickle cell gene will be asymptomatic. When a baby gets a sickle gene from both parents, the abnormal genes are expressed as SS disease. ...Read more

Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


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What are the causes of sickle cell disease and what are some characteristics?

What are the causes of sickle cell disease and what are some characteristics?

Genetic disease: Sickle cell disease means the patient inherited the gene for sickle cell disease from both mother and father. The disease is associated with anemia (low blood) and often some degree of jaundice (yellowness.) people with this problem are more likely to be ill with infections early in life and take antibiotics and receive special vaccinations, to help prevent infections. ...Read more

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Blood doctor, i want to know what are the causes of sickle cell disease?

Blood doctor, i want to know what are the causes of sickle cell disease?

"Undesired Traits": Sickle cell disease is caused by two individuals who both possess sickle cell trait, a condition in which the individuals look normal and do not have the disease, but carry a recessive gene that when combined with a similar person yields sickle cell disease. This condition can be genetically tested prior to having children- especially african americans. ...Read more

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What is the cause of sickle cell disease and trait?

What is the cause of sickle cell disease and trait?

Gene mutation: Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation. ...Read more

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Need expert help here. What are the major causes of sickle cell disease?

Need expert help here. What are the major causes of sickle cell disease?

Gene mutation: Sickle cell disease is caused when an individual inherits two mutated copies (one from each parent) of the beta-hemoglobin gene. The specific dna mutation causes a change from glutamic acid to valine at position 6 within the protein, and this changes the biochemical properties of the beta-hemoglobin chains to cause abnormal polymerization under certain conditions (hypoxia, ph change, etc.). ...Read more

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What would you say are major causes of sickle cell disease?

What would you say are major causes of sickle cell disease?

Gene mutation: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin.The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance. This means that both the mother and the father must pass on the defective form of the gene for a child to be affected. ...Read more

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How much time does it take for sickle-cell disease to cause an autosplenectomy?

How much time does it take for sickle-cell disease to cause an autosplenectomy?

Few years: Patients with homozygous sickle cell anemia (Hgb SS) auto-infarct spleens in first few years of life. Patient's with Hgb SC or sickle cell anemia with hereditary persistence of fetal hemoglobin usually maintain some degree of splenic function. ...Read more

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What diseases could cause RBC to start messing up inside of your body (besides sickle cell)?

What diseases could cause RBC to start messing up inside of your body (besides sickle cell)?

Variety: A variety of diseases can cause red cell issues--from size and number of red cells to breakdown of red cells because of a stress, as infection or immune related problems. The later may be associated with bilirubin (yellowness)--in eyes and skin. ...Read more

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How does a genetic mutation cause sickle-cell disease?

How does a genetic mutation cause sickle-cell disease?

Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. ...Read more

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