Doctor insights on:
What Are Some Of The Longterm Side Effects Of Rituxan
Not common: The long-term side effects are uncommon though can be serious. These include: low immunoglobulin levels, pml (brain infection caused by jc virus), reactivation of hepatitis b infection with resulting liver damage in previously infected patients, and uncommon other serious bacterial, viral and fungal infections. ...Read more
YEs: The first exposure to Rituximab frequently leads to allergic symptoms known as an anaphylactoid reaction. This may lead to red, itchy skin, wheezing, shortness of breath, tightness in the chest, high or low blood pressure. This reaction usually does not happen with subsequent exposure. ...Read more
I have heard chemo has very bad side effects. My dad just had his first chemo with rituximab+chop. Its been 2 days and he's not that bad. Is that normal?
Mostly infusion rxns: Rituxan is given intravenously slowly at first to look for common immediate reactions like chills, fever, shakes, itching, hives, headache all of which could be prevented or lessened by giving premedications like Benadryl (diphenhydramine) and steroids. Reactivation of hepatitis b, lowering resistance to infections, rapid destruction of tumor cells causing i'll effects to organs (tumor lysis) can also occur. ...Read more
Most likely.: What side effects do you speak of? Most side effects of Rituximab occur during the infusion itself; I have very few folks complain of anything afterwards except maybe fatigue (that is if they receive Rituximab by itself). It does suppress the b lymphocytes for months but usually that translates into nothing. Patients who have had heart pain or irregular heartbeats in the past may experience. Reed. ...Read moreSee 1 more doctor answer
What SE?: What side effects (from rituximab)? About 25% of people will have an "infusion reaction" on initial dose with possible hives, shortness of breath, shaking, etc. That is usually not a condition that persists after the infusion is completed. Other side effects can come from killing cancer cells quickly such as tumor lysis syndrome, or some more rare long term Rituximab side effects? ...Read more
Can people take rituximab drug as a treatment of mmn disease alongside IVIg drug as the doctor described and what are the side effects?
Uncertain what mmn?: I would like to help but need more information. Depending on the setting you can use rituxan (rituximab) to help certain conditions and sometimes other meds are used. These are things to discuss with your physician. ...Read more
Dx w/RA & MALT NHL, severe feet swell, rash and extreme bone/joint pain after 2nd dose of Rituxan (rituximab). Will this go away? How long do side effects last??
I m suffering from r. Arthritis after using all the drugs my doctor is now recommending mabthera (rituximab). Wat r its side effects? Is it safe 4 me?
Can be safe: Can be safe if tests for tuberculosis and chest x-ray are normal and there are no major infections present. Side effects are increased susceptibility to infection and slight increase in risk of cancer. The other side effects are less common, but are similar to those found with tumor necrosis factor inhibitors/blockers. ...Read more
Neupogen can increase WBC after late onset neutropenia (LON). Any prescription that gives long term prevention of the LON side effect after Rituximab?
Unknown: Rituxan (rituximab) has been assigned to pregnancy category c by the fda. Animal studies have not been conducted. There are no controlled data in human pregnancy. There are no data on whether Rituxan (rituximab) can cause fetal harm when administered to a pregnant woman.. Postmarketing data indicate that b-cell lymphocytopenia generally lasting less than six months can occur in infants exposed to Rituxan (rituximab) in utero. ...Read more
Median half life 32d: The median half life of Rituxan (rituximab) is 32 days. It takes approximately 5 half-lives before a drug is considered "gone" from the system. Therefore a median time-period would be 160 days from completion of treatment. Remember measurement of drug in the system is not the same as the side-effect of the drug or the length of time the lymphocyte population is affected. ...Read more
Yes: Rituximab is directed against an antigen found on lymphocytes (cd20). It attaches to this antigen and causes destruction of the lymphocyte. Its action is indiscriminate therefore the lymphocyte population is transiently decreased leading to a lowering of the function of the immune system for brief periods of time. ...Read more
Not really: Rituxan (rituximab) is used to treat certain cancers as well as other non-cancer conditions. In the oncology world, we don't think of it as "chemotherapy" because it is a monoclonal antibody that is selective. We use the term chemotherapy for drugs that non-specifically kill fast-growing cells. We call Rituxan (rituximab) a biologic therapy, not chemotherapy. Hope that helps! ...Read moreSee 2 more doctor answers
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