Doctor insights on:
What Are Sickle Cells And Why Are They Important
Sickle cell disease:
You can google it for more details. The wikipedia entry is pretty accurate, although pretty technical.
Sickle cells are a shape of red blood cells caused by a mutation found predominantly in people from sub-saharan regions. The disease can be either mild or severe. Attacks cause severe pain and multiple other complications. ...Read more
Why tested for sickl: There are carriers of sickle cell disease which is called sa or sickle cell trait. For a child to have sickle cell disease he/she has to have sickle cell trait present in both parents. Only if both parents test positive for sickle cell trait then there is one in four chance to have baby with sickle cell ss, anemia, and 2in four chances of sc, or sickle cell trait and1 in four chance normal infant. ...Read more
Keep it in mind.: Sickle trait can become an issue when you visit high altitudes or when dehydrated. Symptoms can include abdominal pain from a swelling of the spleen, or generalized pain. Also sickle trait can be passed on. There are parents who never knew they had sickle trait who have children who are diagnosed with sickle cell disease. Sickle trait is typically not a problem, but keep these things in mind. ...Read more
Sickle cell pain: The vaso-occlusive crisis is caused by sickle-shaped red blood cells that obstruct capillaries and restrict blood flow to an organ, resulting in ischemia, pain, necrosis and often organ damage. Damage to the liver causes jaundice. The pathogenesis of chronic ulcers in scd is complex: mechanical obstruction, venous incompetence, in situ thrombosis, arteriovenous shunting, decreased local oxygen. ...Read more
Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disease will cause strokes, lung problems, leg ulcers etc. If we knew early on who would have it bad, maybe treatments could be given earlier to prevent these problems. But not everyone has it bad, so it is hard to know. ...Read more
Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more
More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more
Anemia, pain, crises:
The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others.
Most patients that have sickle cell trait are completely asymptomatic. ...Read more
Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production. The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood. The blood cell then becomes distorted in the small capillaries and the spleen. The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more
Pain.: When red cells sickle, they become rigid and block the flow of blood. If this happens in muscle or bone, the result is pain. In the lung it's pain and shortness of breath. In the brain, it can cause a stroke. Any organ can be effected. A painful crisis happens when blood flow is interrupted. They are episodic and unpredictable. ...Read more
Types os SIckle Cell:
From nih, division of blood diseases and resources:
sickle cell disease-ss: 65% of us patients; genotype s/s
sickle cell disease-sc: 25% of us patients; genotype s/c
sickle cell disease-s beta + thalassemia: 8% of us patients; genotype betas/ beta + thalassemia
sickle cell disease-s beta 0 thalassemia: 2% of us patients; genotype betas/ beta 0 thalassemia. ...Read more
Vasoocclusive event: Episodes of pain are the most common type of vasoocclusive event. Pain may be precipitated by events such as weather conditions, e, g, high wind speed, low humidity, dehydration, infection, stress, menses, alcohol consumption, and nocturnal hypoxemia. However, the majority of painful episodes have no identifiable cause. ...Read more
So far only one: At present the only cure for sickle cell disease is a bone marrow transplant. This is being done with greater frequency, and many pediatric transplant centers are participating in a trial with this. The biggest limitation to this is the availability of suitable bone marrow donors. Brothers or sisters are best, but they must be a match and have no more than sickle trait. ...Read more
Chronic: Treatment focus is on maintaining hemoglobin levels, preventing "sickle crises", and preventing complications. Depending on blood levels and frequency of sickle crises an outpatient program of blood transfusions will be set up by the hematologist. Preventing complications such as strokes, pneumonias, etc. Is a goal. Hydrea (hydroxyurea) use can help in reducing crises. Some pts can get bone marrow transplants. ...Read more
Several: There are several genetic defects that lead to sickle cell anemia. They all lead to a change in the 6th Amino Acid in the beta-globin chain in which valine is substituted for glutamic acid. At least 5 different dna mutations have been identified that all lead to the same Amino Acid substitution, and thus, sickle cell anemia. ...Read more
Fetal hemoglobin: Sickle cell disease results from a mutation in the beta hemoglobin gene. In infants, the beta hemoglobin gene is largely not used by the body (the gene is "off"). Instead, babies use a different gene named gamma hemoglobin. The gamma hemoglobin does not carry the sickle mutation. During the 1st year of life, the body gradually switches from using gamma to beta. Thus, symptoms can be delayed. ...Read more
Inherited: Sickle cell anemia is hereditary. But it comes in several varieties depending what was inherited from parents. S-s is severe & usually diagnosed in infancy. S-a is carrier state & may go undetected into adulthood. Many variants are possible. This refers to how hemoglobin proteins are manufactured by red cells programmed by genes. See: http://ghr. Nlm. Nih. Gov/condition/sickle-cell-disease. ...Read more
- Talk to a doctor online
- What is sickle cell?
- What causes yellow eye color or jaundice in sickle cell patients?
- What happens if someone effected by sickle cell anemia goes to a normal person?
- Why cognitive development is important?
- Why is bone marrow important?
- Why is lifetime fitness important?
- Why areminerals important?
- Why is exercise important?
- What chromosome carries the gene for sickle cell anemia?