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Doctor insights on: What Are Cyanate And Thiocyanate Can They Be Used To Treat Sickle Cell Anemia

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What are cyanate and thiocyanate? Can they be used to treat sickle cell anemia?

What are cyanate and thiocyanate? Can they be used to treat sickle cell anemia?

Ask ur Hematologist: Dietary cyanate, from foods containing cyanide derivatives, has been used as a treatment for sickle- cell anemia. In the laboratory, cyanate and thiocyanate irreversibly inhibit sickling of red blood cells drawn from sickle cell anemia patients. However, the cyanate would have to be administered to the patient for a lifetime, as each new red blood cell created must be prevented from sickling. ...Read more

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Dr. James Ball
356 doctors shared insights

Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


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Why are red blood cell transfusions commonly used to treat some patients with anemia?

Replacement: Anemia is basically a lower than normal number of red blood cells. If it is bad enough, it may be life-threatening because red cells carry oxygen to tissues. A transfusion fixes (at least temporarily) the problem by "filling the tank". Transfusions carry their own risks and are not treated lightly by doctors! ...Read more

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What blood type is administered to those that have sickle cell anemia?

What blood type is administered to those that have sickle cell anemia?

Type-specific: Type specific blood is given. In those patients who require blood transfusions very frequently, the providers often will expand the blood typing to include a number of addition blood typing systems. We call this an expanded phenotyping of blood. ...Read more

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What are effective ways to treat the symptoms of sickle cell anemia?

What are effective ways to treat the symptoms of sickle cell anemia?

See below: Sickle cell anemia can be very difficult to treat. Avoiding any known precipitating circumstance may help. Keep well hydrated. There are medications that may help if crises are frequent or severe. Blood (exchange) transfusions may also help if crises are severe or frequent. Consult with a hematologist who treats people with sickle cell anemia. ...Read more

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What can be done for sickle cell trait and iron deficiency?

What can be done for sickle cell trait and iron deficiency?

Straightforward: Sickle cell trait is not a disease, it is a genetic mutation. In most cases it has no health problems associated with it. The only thing to be "done" for it is to ensure the person with it understands the significance that having it might have on their children. Iron deficiency responds to iron therapy; depending on the pt's age and situation tests may be needed to determine why it developed. ...Read more

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What is the blood type given to those who have sickle cell anemia?

What is the blood type given to those who have sickle cell anemia?

Same rules...: If a person with sickle cell disease requires a transfusion, the rules governing which blood types are safe are the same as for the general population. ...Read more

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Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read more

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What can cause hemoglobin & hematacrit to be low in children?

What can cause hemoglobin & hematacrit to be low in children?

Low H/H: The most common reason for anemia in children is iron deficiency. The first step in resolving iron deficiency anemia in children is by increasing intake through iron rich foods, such as meat, poultry and fish. If this doesn't help, an iron supplement may be needed. Your doctor can help you with this. ...Read more

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Why is it that carriers of sickle cell anemia are immune to malaria?

Why is it that carriers of sickle cell anemia are immune to malaria?

Can be infected: Having Sickle Cell traits doesn't actually mean that a person can't become infected w/ Malaria. But, it certainly helps with resistance. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16..." ...Read more

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What are some ways (self-treatment) to prevent or help deal with sickle cell anemia?

What are some ways (self-treatment) to prevent or help deal with sickle cell anemia?

Depends: It depends on the type of sickle cell anemia. Assuming hemoglobin ss disease we recommend good hydration, avoidance of heavy exercise, avoidance of nicotine. It is really a cumbersome topic though these are the major ones. I would ask your physician, they should be able to provide you with education on prevention of sickle cell crises. Sickle cell is genetic, inherited from mom and dad. ...Read more

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Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

Sickle Cell /Malaria: In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” ...Read more

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Can someons parents have sickle cell anemia and then they don't get the trait nor the anemia?

Another possibility: One sickle cell syndrome is a combination of sickle cell trait and beta thalassemia. The symptoms are most like sickle cell disease. If this person had children, they could pass on the beta thalassemia and not the sickle cell. Otherwise, people sickle cell disease will have children with either trait or disease. ...Read more

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Are there other tests to determine sickle cell anemia risk if my husband is away serving in the military?

Are there other tests to determine sickle cell anemia risk if my husband is away serving in the military?

Yes: The first step is testing you for sickle cell carrier status. If not a carrier then no further testing needs to be done. If you are a carrier then the next step is check the father of the baby. If he is unavailable you could have his parents tested. If neither are a carrier then the father can not be a carrier either. If they are carriers then the fathers chances are 50% he is also. ...Read more

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Low potassium and magniseum in sickle cell patient, how can this be corrected?

Low potassium and magniseum in sickle cell patient, how can this be corrected?

Dietary sources: Don't forget Folic Acid either. Here is some great nutritional info: http://www.Healthaliciousness.Com/articles/foods-high-in-magnesium.Php and http://www.Healthaliciousness.Com/articles/food-sources-of-potassium.Php and http://www.Healthaliciousness.Com/articles/foods-high-in-folate-vitamin-b9.Php. ...Read more

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Interested to know if people with sickle cell anemia usually get splenectomies?

Interested to know if people with sickle cell anemia usually get splenectomies?

Sometimes: Occasionally patients with sickle cell disease will have a splenectomy. It usually occurs if the spleen gets to large and it is life-threatening. ...Read more

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How does gene therapy be used to cure someone with sickle cell anemia?

Replace gene: Gene therapy could be used to transfer a new replacement normal gene to cells producing red blood cells. That is how gene therapy would work however there are no approved gene therapy treatments for sickle cell anemia. ...Read more

Dr. Liawaty Ho Dr. Ho
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What are the tests for sickle cell anemia?

Dr. Liawaty Ho Dr. Ho
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Hb electrophoresis: CBC and hemoglobin electrophoresis have to be done -at least- to make a diagnosis of sickle cell anemia. ...Read more

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Can polycythemia be hereditary? What is the gene for too many red blood cells?

Can polycythemia be hereditary?  What is the gene for too many red blood cells?

Maybe "genetic risk: Polycythemia can be acquired. It is a natural respohse to living on a high mountain. There are oxygen censors in the brainstem and if oxidation is compromised a signal goes to the kidney to produce erythropoietin. This then signals the bone marrow to produce more red cells to compensate for the rarefied air. Exactly the same thing can happen with vitamin b1 deficiency induced by excess of sugar. ...Read more

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Sickle cell anemia question. Are the blood cells normal unless there's an illness and then they sickle?

Sickle cell anemia question.  Are the blood cells normal unless there's an illness and then they sickle?

No: In sickle cell anemia, the red cells are always "deformed". Certain things (dehydration, hypoxemia) will further increase the "sickling" causing an increase in symptoms. ...Read more

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Dr. Steven Ginsberg
1,285 doctors shared insights

Anemia (Definition)

A condition marked by a deficiency of red blood cells or hemoglobin in the blood, resulting ...Read more