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Doctor insights on: Wellbutrin Interactions

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Dr. Alan Ali
779 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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My pdoc told me that interactions between Wellbutrin (bupropion) and Aripiprazole are nothing to worry in my case. But on the internet I read "major interaction".

My pdoc told me that interactions between Wellbutrin (bupropion) and Aripiprazole are nothing to worry in my case. But on the internet I read "major interaction".

Interactions: Drug interactions doesn't mean that two drugs shouldn't be taken together. It means they interact. Most commonly, and in this case, they refer to how they may influence each others' metabolism -- resulting in either a higher or lower lever. People vary in metablism of drugs. And, it means, as your doctor probably knows, that doses are incremented in small amounts and slowly, for safety. ...Read more

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Do wellbutrin (bupropion) and weed have an interaction?

Do wellbutrin (bupropion) and weed have an interaction?

Wellbutrin/Weed: Additive effect leading to psychotic symptoms due to elevation of dopamine. Would certainly not recommend that. ...Read more

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Why does wellbutrin (bupropion) say to not consume alcohol if there is no drug interaction?

Why does wellbutrin (bupropion) say to not consume alcohol if there is no drug interaction?

Product Labels: Product labels are designed to ensure that people who use the medication are as safe as possible, also some of the labelling is based on the class of agent rather than on specific information about the medication. So, you will find that the don't consume alcohol warning is on almost every, if not every, psychotropic agent. General experience is that a glass of wine at night is fine. ...Read more

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My pdoc prescribed me wellbutrin (bupropion) and i take lithium and zoloft. What are the interactions when i take the meds? What should I expect?

Depends on dose: Zoloft and wellbutrin (bupropion) are moderate, dose-related inhibitors of cyp450 2d6 for which zoloft partly depends upon for its metabolism. Zoloft usually only inhibits 2d6 at higher doses (150-200mg). It might be worthy to be genotyped for this enzyme to assure you are a extensive metobolizer (em) type. Lithium is mostly excreted unchanged by kidneys. Please follow-up regularly with your doctor. ...Read more

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I am currently on Wellbutrin (bupropion) XL and Lexapro and was prescribed Tramadol. Wanted to see if there was a bad interaction if taken together?

Requires Tact: Combination of SSRI such as Lexapro can apparently cause serotonin syndrome. In addition, the manufacturer of tramadol notes concomitant therapy with SSRI increases risk of seizures.Furthermore, both Tramadol and Wellbutrin (bupropion) can lower the seizure threshold. PGT testing to determine CYP2D6 status may be able to guide treatment. The prescribing physician(s) should be informed of this combination. ...Read more

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Is there an drug interaction with Haldol, (haloperidol) Olanzapine, Zyprexa and the antidepressant Wellbutrin?

Is there an drug interaction with Haldol, (haloperidol) Olanzapine, Zyprexa and the antidepressant Wellbutrin?

Yes there are: Zyprexa (olanzapine) is the trade name for Olanzapine so you only have 3 unique drugs listed though some would argue that brand & generic named drugs are technically 2 distinct forms of chemical compounds. There are several SIGNIFICANT reactions (heart rhythm, sedation, neurological issues) that could occur with these drugs so you should talk things over with your doctor if there are concerns or side effects. ...Read more

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Can i take Zofran for nausea if i take Wellbutrin (bupropion) xl everyday for depression? I read online there was a major drug interaction.

Can i take Zofran for nausea if i take Wellbutrin (bupropion) xl everyday for depression?  I read online there was a major drug interaction.

Drug interaction..: There is a drug interaction between Zofran (ondansetron) and Wellbtutrin called "serotonin syndrome." It means an excessive amount of serotonin in the brain. Can be quite serious. Please discuss with prescribing doctor. I hope this helps. Take care. ...Read more

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Take geodon (ziprasidone) at night, wellbutrin, propanolol in the morning. Cansmoking pot or drinking alcohol harm me? I can't seem to find info on drug interactions

Take geodon (ziprasidone) at night, wellbutrin, propanolol in the morning. Cansmoking pot or drinking alcohol harm me? I can't seem to find info on drug interactions

Yes, can harm you: Yes, adding pot and alcohol to geodon, (ziprasidone) wellbutrin, and propanolol can harm you. The result can be a lot of sedation -- not to mention destabilizing mood and potentially driving psychosis. Discuss this with your own physician. Check it out with your pharmacist also. ...Read more

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Wellbutrin (bupropion) XL 300mg daily & 40mg of Adderall XR . My doctor wants to wean me off the Wellbutrin (bupropion) eventually. Is this because off an interaction?

There really: Isn't any significant interaction. But to be honest, why not just inquire with your doctor why the desires to taper you off of the Wellbutrin (bupropion). As you are better just going to the source rather than possible guesses. Remember to always be your own patient advocate and always make sure that you are key part of your own care! Best of luck. ...Read more

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Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more