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Doctor insights on: Wegeners Granulomatosis In Children

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Causes of wegeners granulomatosis and treatment?

Causes of wegeners granulomatosis and treatment?

Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more

Dr. Patricia Foster
32 Doctors shared insights

Wegener's Granulomatosis (Definition)

Wegener's granulomatosis (Granulomatosis with polyangiitis) causes vasculitis (inflammation blood vessels of nose, sinuses, throat, lungs & kidneys). ...Read more


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Has anyone ever heard of the disease wegeners granulamatosis?

Has anyone ever heard of the disease wegeners granulamatosis?

Yes: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more

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What is the disease wegeners granulamatosis in kids?

What is the disease wegeners granulamatosis in kids?

WG: Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed (called vasculitis). This limits blood flow to tissues and can affect any organ. WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. Its cause is unknown. ...Read more

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What is the definition or description of: granulomatosis?

What is the definition or description of: granulomatosis?

Granulomatosis is: A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive processes such as sarcoidosis. ...Read more

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What is the definition or description of: Wegener's granulomatosis?

What is the definition or description of: Wegener's granulomatosis?

Wegener's granulomat: Wegener's granulomatosis (Granulomatosis with polyangiitis) causes vasculitis (inflammation blood vessels of nose, sinuses, throat, lungs & kidneys). See: http://www. Mayoclinic. Org/diseases-conditions/granulomatosis-with-polyangiitis/symptoms-causes/dxc-20167228 ...Read more

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Can you tell me what wegeners vasculitis?

Can you tell me what wegeners vasculitis?

Serious illness: Wegner's granulomatous angiitis is caused by antibodies against a particular protein in neutrophils. Once uniformly fatal, it is now usually managed with strong medications by specialists. The eyes, ears, throat, lungs and kidneys are the usual targets. Wegener's greatness as a physician is tarnished by his having served the third reich, though not in the death camps; some avoid his name. ...Read more

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What is the mortality rate of a wegeners patient under treatment?

What is the mortality rate of a wegeners patient under treatment?

Lower than ever: The prognosis for wegener's is actually fairly good with the newer therapies. If the absence of severe kidney or neurologis involvement most patients do well. ...Read more

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Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?

Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?

Uncommon problems: ...Like wegener's require someone with experience to manage all the myriad manifestations and potential problems (how's that for alliteration) that can come with the disease or its treatment. Its possible but unlikely that your regular doctor has such experience, if I had wegener's I would be looking to at least have my doctor consult with someone who sees this problem frequently. ...Read more

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I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis

I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis

Anemia? Cause? Chemo: Anemia can be caused by blood loss or impaired production of red cells. Wegner's often requires treatment with a chemotherapy drug which can also be the cause of Anemia. Your treating doctor should be able to explain all this to you. Are you taking treatment for your Wegner's Gran.??? ...Read more

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How can I live with wegeners disease?

Vasculitis: Wegeners granulomatosis now known as granulomatosis with polyangiitis is incurable vasculitis that effects the nose, lungs, and kidneys. It requires life long immunosupressant. With treatment five year survival is 87%. ...Read more

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Could you give me information on wegeners?

Autoimmunity rarity: Wegener's granulomatosis is a rare autoimmune condition that causes inflammation of blood vessels and tissues, usually the nose, mouth, ears, lungs, or kidneys. Untreated it was usually fatal in the past but new treatments have been developed that make this disease treatable. The doctor to see is a rheumatologist. See http://www. Mayoclinic. Org/diseases-conditions/wegeners-granulomatosis/basics/. ...Read more

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What are symptoms of wegener's granulomatosis?

See details: The most common presenting symptom is a chronic sinusitis but there can be numerous other issues associated with wegener's including arthritis, pneumonia, eye problems, kidney disease and cardiac and neurologic issues. ...Read more

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What are the tests for wegener's granulomatosis?

What are the tests for wegener's granulomatosis?

ANCA and biopsy: The most useful blood test is an anca with titer and pattern, and pr3/mpo confirmation. Biopsy of the affected tissue is also important. Imaging studies of the lungs and sinuses can be useful as well as blood and urine tests looking for kidney damage. Finally, EMG might be needed if there is concern for nerve damage. ...Read more

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Wegeners significance of + anca?

Wegeners significance of + anca?

Most are ANCA+!: Wegener's granulomatosis is part of a larger group of vasculitic syndromes, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ancas (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels. Apart from wegener's, this category includes churg–strauss syndrome and microscopic polyangiitis. ...Read more

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What is lymphomatoid granulomatosis?

What is lymphomatoid granulomatosis?

Granulomatosis: It is a lymphoproliferative disorder (lymphomatoid means lymphoma-like). The word granulomatosis denotes one of its microscopic character, polymorphic lymphoid infiltrates and focal necrosis within it. It usually involves lung, skin, and central nervous system. It is caused by the epstein barr virus (same virus causes mono). No proven treatment but research trials are being done at nih. ...Read more

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Could a bronchoscopy tell what caused wegener's granulomatosis?

Could a bronchoscopy tell what caused wegener's granulomatosis?

No it cannot: A bronchoscopy is useful for identifying that wegener's is affecting the lungs but it will not tell you the cause. Wegener's is in a class of conditions known as autoimmune. This is where the body does not recognize its own cells as being "self". In turn an immune response causes inflammation in the lungs, eyes and sinuses (the classic locatioins in the body to be affected by wegeners). ...Read more

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Please tell me what wegeners vasculitis is?

See details: This is a serious systemic vasculitis characterized by inflammatory in medium-sized arteries. Clinical manifestation often start with chronic sinusitis or recurrent lung infiltrates but multiple organs can be involved including the kidneys. It must be treated aggressively to prevent serious complications. See a rheumatologist. ...Read more

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What is wegener's granulomatosis vasculitis?

See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more

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Please tell me what orofacial granulomatosis is?

Please tell me what orofacial granulomatosis is?

See details: This is an inflammatory condition effecting the face and lips. It is most common in the early adult years. Occasionally there may also be swelling or burning of the tongue or gums. It seems to occur more commonly in patients with Crohn's disease and sarcoidosis. However, the cause is unknown. TNF agents such as Remicade (infliximab) are now considered the treatment of choice. ...Read more

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What's a good description of wegener's granulomatosis vasculitis?

Systemic vasculitis: Wegener's is a systemic vasculitis associated with the presence of specific blood tests known as a canca or pr3 antibodies. It usually presents as chronic sinusitis and more rarely pneumonia but can effect other areas of the body especially the kidneys, eyes, heart and nervous system. It is very serious but newer medications have provided effective treatment in most cases. ...Read more

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Will wegener's granulomatosis kill me if I don't get treatment?

Will wegener's granulomatosis kill me if I don't get treatment?

Yes: Wegener's will not go away. It might take time but will ultimately cause severe lung and kidney problems, and death. Treatment can be very effective. ...Read more

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What is wegner's granulomatosis?

Serious condition: This is a very rare disease which is a form of vasculitis (inflammation of the blood vasculitis) it commonly causes, sinusitis, has associated lung nodules and is associated with varying degrees of kidney damage which can lead to kidney failures. But it is treatable, usually requiring chemotherapy (although it is not cancerous!). ...Read more

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What is wegener's granulomatosis?

What is wegener's granulomatosis?

Wegener's: Granulomatosis is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. ...Read more

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Please advise what is wegener's granulomatosis?

Immune vasculitis: The antobodies found in the test and that cause the disease are directed against an antigen within neutrohils. Untreated, Wegener's (granulomatous angiitis for those who cannot forgive Dr. Wegener's being a German during WWII) is fatal. Nowadays it can be managed using cyclophosphamide and/or perhaps other powerful agents and most people eventually recover. ...Read more

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Wegeners desease how long will you survive this illness?

Survival: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more

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How can someone live and cope with having wegeners disease?

Living with Wegeners: I am sorry about your diagnosis. Wegener's disease is hard. Incurable, the five-year survival is up to 87%. Since this is an average number, some will live longer. The treatment is immunosupression, which is life saving, but it does also have some toxicity which, sadly can also be fatal. Happily, there are many people who are currently living quite normal lives of 30 years or more on treatment. ...Read more

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Wegeners disease, what is the survival rate for people with this disease?

Wegeners disease, what is the survival rate for people with this disease?

See details: The long term survival rate is fairly high and is a result of newer therapies such as rituxan (rituximab). ...Read more

Dr. Walter Husar
44 Doctors shared insights

Granulomatosis (Definition)

A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive ...Read more