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Doctor insights on: Wegeners Granulomatosis Blood

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What is wegener's granulomatosis vasculitis?

What is wegener's granulomatosis vasculitis?

See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more

Dr. Ira Friedlander
34 doctors shared insights

Wegener's Granulomatosis (Definition)

Wegener's granulomatosis (Granulomatosis with polyangiitis) causes vasculitis ( inflammation blood vessels of nose, sinuses, throat, lungs ...Read more


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What causes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)?

What causes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)?

The exact causes of GPA — formerly known as Wegener's granulomatosis — and MPA are unknown: GPA and MPA are both types of inflammation of the blood vessels (vasculitis). It is believed that one or more genetic and environmental factors, such as infections, allergic reactions, certain drugs and diseases, might trigger an abnormal immune system response that causes GPA and MPA symptoms. However, no specific infection or event has been identified as the cause. GPA and MPA develop when the immune system mistakenly identifies blood vessel cells as foreign invaders and attacks them. The vessels become inflamed, causing them to narrow or close off, disrupting the flow of blood to various organs and causing organ and tissue damage. No matter the cause, early diagnosis and treatment of GPA and MPA are essential for a full recovery. ...Read more

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Does a high IgA value indicate churg strauss in chronic pulmonary disease?

Does a high IgA value indicate churg strauss in chronic pulmonary disease?

Is it IgE: I assume you are referring to ige rather than IgA levels. High levels of ige in a patient with uncontrolled asthma raises the suspicion of churg-strauss vasculitis. Talk to your doctor as intensive medication regimen is indicated if it is truly the cause. A pulmonologist /rheumatologist would be the one to talk to. ...Read more

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What is wegeners vasculitis?

What is wegeners vasculitis?

Disease or Syndrome?: Wegener's granulomatosis (wg), more recently granulomatosis with polyangiitis (wegener's) (gpa), is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. Due to its end-organ damage, it is life-threatening and requires long-term immunosuppression.[1] five-year survival is up to 87%, with some of the mortality due to toxicity of rx. ...Read more

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Can blood transfusions cure any autoimmune diseases?

Can blood transfusions cure any autoimmune diseases?

Autoimmune uncure: A cure for any autoimmune disease is most evasive. A blood transfusion regrettably isn't likely the answer either. ...Read more

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How are pulmonary sarcoidosis and autoimmune diseases related?

The immune system.: Different parts of the immune system are involved in causing (due to an excessive reaction) problems in autoimmune diseases vs. Sarcoidosis . The cause of sarcoidosis is unknown. ...Read more

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P-Anca positive, negative MPO??? Wegener's vasculitis suspected due to clinical symptoms. 6 yr old with juvenile arthritis.

Autoimmune: The positive ANCA test supports the diagnosis of an autoimmune disorder but with a negative MPO test (of one the proteins in the neurophils targeted by the disease) the possible diagnoses are many including Wegener's, RA, and others. Further testing including a biopsy may be required. ...Read more

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Are Crohn's disease, tuberculosis and sarcoidosis all different types of auto-immune diseases?

Are Crohn's disease, tuberculosis and sarcoidosis all different types of auto-immune diseases?

No: Crohn's disease is an inflammatory disease but is not strictly speaking autoimmune. Tuberculosis is an infectious disease caused by mycobacterium tuberculosis. Sarcoidosis is a granulomatous disease that we don't quite know the cause of. ...Read more

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Will a typical blood panel for autoimmune diseases detect graves disease?

Will a typical blood panel for autoimmune diseases detect graves disease?

Need specific test: You need to be testing for graves disease - there is no shotgun test for all autoimmune disorders. ...Read more

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Causes of wegeners granulomatosis and treatment?

Causes of wegeners granulomatosis and treatment?

Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more

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With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?

With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?

SLE DPGN is bad.: The degree of remaining renal function dictates the inability of the kidney to excrete waste products and manage potassium levels. In any severe kidney disease when egfr approaches 15 ml/min uremia and elevated k+ levels are frequently noted. ...Read more

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Is lupus erythematosus infectious?

Is lupus erythematosus infectious?

No: Is a immune based disease does not recognize self and attacks multiple organs. ...Read more

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What are degenerative blood vessel diseases?

What are degenerative blood vessel diseases?

Atherosclerosis: Atherosclerosis of blood vessels is the major degenerative disorder. ...Read more

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Is polyarteritis nodosa always an autoimmune disease?

Is polyarteritis nodosa always an autoimmune disease?

Polyarteritis nodosa: Pan ( poly arteritis nodosa) is a disease of unknown cause.It affects small to medium sized arteries reducing or cutting off blood supply to organs . Men are affected more than women between ages of 30 to 50 . In 25% of patients hepatitis b or c infection is seen. Small and medium arteries are attacked by immune cells . It is immune mediated and exact cause is not known. ...Read more

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Is polyarteritis nodosa an autoimmune disease?

Is polyarteritis nodosa an autoimmune disease?

Polyarteritis causes: The answer to your question is "it may be" an auto-immune disorder. Polyarthritis is most often caused by an auto-immune disorder such as rheumatoid arthritis, amyloidosis, psoriatic arthritis, and lupus erythematosus. In addition, it may also be caused by infection with an alphavirus such as chikungunya virus and ross river virus. Ask your physician for more information in your instance. ...Read more

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How are systemic lupus erythematosus, coma & leukopenia related?

How are systemic lupus erythematosus, coma & leukopenia related?

SLE: Is a systemic disease and is a form of vascullitis, which means that there is inflammation in the blood vessels as a result it is a multi-system disease and can affect any organ in the body. When the brain is affected it can lead to changes in mood, psychosis and even coma. Leukopenia is a recognized feature of SLE at some point in the course of the disease. It can affect the kidneys, joints etc ...Read more

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How are ANA blood tests related to autoimmune disease?

One marker: Anti-nuclear antibodies (ANA) are one marker of auto-immune disease. There are sub-types of ANA that have specificity for different diseases. The antibodies may not be the casue of disease, but a marker of the disorder. ...Read more

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What's a good description of wegener's granulomatosis vasculitis?

Systemic vasculitis: Wegener's is a systemic vasculitis associated with the presence of specific blood tests known as a canca or pr3 antibodies. It usually presents as chronic sinusitis and more rarely pneumonia but can effect other areas of the body especially the kidneys, eyes, heart and nervous system. It is very serious but newer medications have provided effective treatment in most cases. ...Read more

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Dr. Jeffrey Wint
46 doctors shared insights

Granulomatosis (Definition)

A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive ...Read more