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Doctor insights on: Wegener S Granulomatosis Causes

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Causes of wegeners granulomatosis and treatment?

Causes of wegeners granulomatosis and treatment?

Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more

Dr. Alan Ali
46 doctors shared insights

Granulomatosis (Definition)

A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive ...Read more


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What is the disease wegeners granulamatosis in kids?

What is the disease wegeners granulamatosis in kids?

WG: Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed (called vasculitis). This limits blood flow to tissues and can affect any organ. WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. Its cause is unknown. ...Read more

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What is wegeners?

What is wegeners?

Wegener's: Granulomatosis is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. ...Read more

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How can I live with wegeners disease?

How can I live with wegeners disease?

Vasculitis : Wegeners granulomatosis now known as granulomatosis with polyangiitis is incurable vasculitis that effects the nose , lungs , and kidneys. It requires life long immunosupressant. With treatment five year survival is 87%. ...Read more

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Could you give me information on wegeners ?

Could you give me information on wegeners ?

Autoimmunity rarity: Wegener's granulomatosis is a rare autoimmune condition that causes inflammation of blood vessels and tissues, usually the nose, mouth, ears, lungs, or kidneys. Untreated it was usually fatal in the past but new treatments have been developed that make this disease treatable. The doctor to see is a rheumatologist. See http://www.mayoclinic.org/diseases-conditions/wegeners-granulomatosis/basics/. ...Read more

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Wegeners desease how long will you survive this illness?

Probably for life: Truth be told, it's likely vanish after a few years. Stay alert, comply with your medications meticulously. Before modern rx, everybody died of it. Dr. Wegener. Like some other decent folks joined the wrong political party as a young man, but be grateful to him anyway for his genius in identifying a disease from which the fast majority of folks now recover. ...Read more

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What is wegeners vasculitis?

Disease or Syndrome?: Wegener's granulomatosis (wg), more recently granulomatosis with polyangiitis (wegener's) (gpa), is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. Due to its end-organ damage, it is life-threatening and requires long-term immunosuppression.[1] five-year survival is up to 87%, with some of the mortality due to toxicity of rx. ...Read more

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Wegeners significance of + anca?

Wegeners significance of + anca?

Most are ANCA+!: Wegener's granulomatosis is part of a larger group of vasculitic syndromes, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ancas (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels.Apart from wegener's, this category includes churg–strauss syndrome and microscopic polyangiitis. ...Read more

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Wegeners disease, what is the survival rate for people with this disease?

Wegeners disease, what is the survival rate for people with this disease?

See details: The long term survival rate is fairly high and is a result of newer therapies such as rituxan (rituximab). ...Read more

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How long can wegeners go undiagnosed? Can a patirnt have vague symptoms (still be able to funcion) for months before a diagnosis is made?

How long can wegeners go undiagnosed?  Can a patirnt have vague symptoms (still be able to funcion) for months before a diagnosis is made?

Yes!: Delayed diagnosis can be caused by "vague" symptoms; mild disease at onset; the fact that wegener's is quite uncommon for an autoimmune disease. This rheumatic immune problem is best dealt with by a specialist in rheumatology. ...Read more

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Please tell me what wegeners vasculitis is?

See details: This is a serious systemic vasculitis characterized by inflammatory in medium-sized arteries. Clinical manifestation often start with chronic sinusitis or recurrent lung infiltrates but multiple organs can be involved including the kidneys. It must be treated aggressively to prevent serious complications. See a rheumatologist. ...Read more

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Can you tell me what wegeners vasculitis?

Serious illness: Wegner's granulomatous angiitis is caused by antibodies against a particular protein in neutrophils. Once uniformly fatal, it is now usually managed with strong medications by specialists. The eyes, ears, throat, lungs and kidneys are the usual targets. Wegener's greatness as a physician is tarnished by his having served the third reich, though not in the death camps; some avoid his name. ...Read more

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What is the mortality rate of a wegeners patient under treatment?

What is the mortality rate of a wegeners patient under treatment?

Lower than ever: The prognosis for wegener's is actually fairly good with the newer therapies. If the absence of severe kidney or neurologis involvement most patients do well. ...Read more

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My wife has been diagnosed with wegeners GPA. She is on prednisone and has been prescribed methotrexate. Are there any less toxic alternatives?

My wife has been diagnosed with wegeners GPA. She is on prednisone and has been prescribed methotrexate. Are there any less toxic alternatives?

GPA: First of all I wish your wife all the best with full remission of the disease and uneventful maintenance of the remission. The drugs she is on are just fine so long she is followed up regularly by her rheumatologist / primary doctor for adjustment and fine tuning. There are rather more toxic drugs than what she is currently on, good that she is responding to the current drug regimen, best wishes ...Read more

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I have wegeners , complete with nasal and palate perforations. I had acute renal failure, am on treatment and having relapses. Odds for survival?

I have wegeners , complete with nasal and palate perforations. I had acute renal failure, am on treatment and having relapses. Odds for survival?

Fair to good: Acute kidney failure can be reversed in healthy individuals. Wagener's is present so recovery may never be complete. The only thing i know, other than your social drinking, about your medical history is your intake of cyclophosphamide. There are other medications like imuran, (azathioprine) methotrexate, etc. Used in the treatment of wagener's that have promising positive results. Visit the mayo clinic. ...Read more

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