Doctor insights on:
Wegener S Granulomatosis
I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis
Anemia? Cause? Chemo: Anemia can be caused by blood loss or impaired production of red cells. Wegner's often requires treatment with a chemotherapy drug which can also be the cause of Anemia. Your treating doctor should be able to explain all this to you. Are you taking treatment for your Wegner's Gran.??? ...Read more
Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more
WG: Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed (called vasculitis). This limits blood flow to tissues and can affect any organ. WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. Its cause is unknown. ...Read more
Yes: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more
Autoimmunity rarity: Wegener's granulomatosis is a rare autoimmune condition that causes inflammation of blood vessels and tissues, usually the nose, mouth, ears, lungs, or kidneys. Untreated it was usually fatal in the past but new treatments have been developed that make this disease treatable. The doctor to see is a rheumatologist. See http://www. Mayoclinic. Org/diseases-conditions/wegeners-granulomatosis/basics/. ...Read more
Survival: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more
Living with Wegeners: I am sorry about your diagnosis. Wegener's disease is hard. Incurable, the five-year survival is up to 87%. Since this is an average number, some will live longer. The treatment is immunosupression, which is life saving, but it does also have some toxicity which, sadly can also be fatal. Happily, there are many people who are currently living quite normal lives of 30 years or more on treatment. ...Read more
Disease or Syndrome?: Wegener's granulomatosis (wg), more recently granulomatosis with polyangiitis (wegener's) (gpa), is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. Due to its end-organ damage, it is life-threatening and requires long-term immunosuppression. five-year survival is up to 87%, with some of the mortality due to toxicity of rx. ...Read more
Most are ANCA+!: Wegener's granulomatosis is part of a larger group of vasculitic syndromes, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ancas (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels. Apart from wegener's, this category includes churg–strauss syndrome and microscopic polyangiitis. ...Read more
See details: The long term survival rate is fairly high and is a result of newer therapies such as rituxan (rituximab). ...Read more
How long can wegeners go undiagnosed? Can a patirnt have vague symptoms (still be able to funcion) for months before a diagnosis is made?
See details: This is a serious systemic vasculitis characterized by inflammatory in medium-sized arteries. Clinical manifestation often start with chronic sinusitis or recurrent lung infiltrates but multiple organs can be involved including the kidneys. It must be treated aggressively to prevent serious complications. See a rheumatologist. ...Read more
Serious illness: Wegner's granulomatous angiitis is caused by antibodies against a particular protein in neutrophils. Once uniformly fatal, it is now usually managed with strong medications by specialists. The eyes, ears, throat, lungs and kidneys are the usual targets. Wegener's greatness as a physician is tarnished by his having served the third reich, though not in the death camps; some avoid his name. ...Read more
Lower than ever: The prognosis for wegener's is actually fairly good with the newer therapies. If the absence of severe kidney or neurologis involvement most patients do well. ...Read more
My wife has been diagnosed with wegeners GPA. She is on prednisone and has been prescribed methotrexate. Are there any less toxic alternatives?
GPA: First of all I wish your wife all the best with full remission of the disease and uneventful maintenance of the remission. The drugs she is on are just fine so long she is followed up regularly by her rheumatologist / primary doctor for adjustment and fine tuning. There are rather more toxic drugs than what she is currently on, good that she is responding to the current drug regimen, best wishes ...Read more
I have wegeners, complete with nasal and palate perforations. I had acute renal failure, am on treatment and having relapses. Odds for survival?
Fair to good: Acute kidney failure can be reversed in healthy individuals. Wagener's is present so recovery may never be complete. The only thing I know, other than your social drinking, about your medical history is your intake of cyclophosphamide. There are other medications like imuran, (azathioprine) methotrexate, etc. Used in the treatment of wagener's that have promising positive results. Visit the mayo clinic. ...Read more
I'm 33, 3 c-sections tubes tied in 2006, I also have Wegners Granulomatosis, chemotherapy within the next week. Don't remember last period Pregnant????
Immune vasculitis: The antobodies found in the test and that cause the disease are directed against an antigen within neutrohils. Untreated, Wegener's (granulomatous angiitis for those who cannot forgive Dr. Wegener's being a German during WWII) is fatal. Nowadays it can be managed using cyclophosphamide and/or perhaps other powerful agents and most people eventually recover. ...Read more
ANCA and biopsy: The most useful blood test is an anca with titer and pattern, and pr3/mpo confirmation. Biopsy of the affected tissue is also important. Imaging studies of the lungs and sinuses can be useful as well as blood and urine tests looking for kidney damage. Finally, EMG might be needed if there is concern for nerve damage. ...Read more
It is not: It is an autoimmune illness that strikes at random. ...Read more
Rash sinus lung: It is called polyangiitis with granulomatosis and is different in different people. This problem is caused by inflammation in the blood vessels which go everywhere in the body. Common symptoms include rash, sinus inflammation, lung problems which can be manifest by a cough. The kidney can be involved also but often this is asymptomatic. We can see other sites like the eyes, nose, etc. ...Read more
No it cannot: A bronchoscopy is useful for identifying that wegener's is affecting the lungs but it will not tell you the cause. Wegener's is in a class of conditions known as autoimmune. This is where the body does not recognize its own cells as being "self". In turn an immune response causes inflammation in the lungs, eyes and sinuses (the classic locatioins in the body to be affected by wegeners). ...Read more
See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more
Systemic vasculitis: Wegener's is a systemic vasculitis associated with the presence of specific blood tests known as a canca or pr3 antibodies. It usually presents as chronic sinusitis and more rarely pneumonia but can effect other areas of the body especially the kidneys, eyes, heart and nervous system. It is very serious but newer medications have provided effective treatment in most cases. ...Read more
Attacks organs: Wegener's granulomatosis (wg), also known as recently granulomatosis with polyangiitis results in inflammation of blood vessels vasculitis. Wg mainly affects nose, lungs, kidneys and other organs. Treatment is long-term immunosuppression to reduce antibodies which are thought to "attack" the medium and small blood vessels. Dr. Friedrich wegener described the disease in 1936. ...Read more
Sister just diagnosed with wegener's granulomatosis, she has much pain No kidney damage noted, what is her prognosis?
No kidney damage: Prognosis is favorable without kidneys being affected. But lungs should certainly be watched very closely. Treatment options are favorable. Please ask her to work on stress management. This is vital as stress-emotional/physical/situational-can make disease worse. This is not theoretical. This is fact. ...Read more
Friend has disseminated histoplasmosis and wegener's granulomatosis. What is the treatment for both of them at the same time.
Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?
Uncommon problems: ...Like wegener's require someone with experience to manage all the myriad manifestations and potential problems (how's that for alliteration) that can come with the disease or its treatment. Its possible but unlikely that your regular doctor has such experience, if I had wegener's I would be looking to at least have my doctor consult with someone who sees this problem frequently. ...Read more
Husband diagnosed with wegener's granulomatosis. Will his lung & kidney function return to normal?
Chance: In the past, wegener's granulomatosis was usually fatal. Currently, we have new and excellent treatment for the disease and some patients with kidney and lung disease have gone into remission. That does not always mean that the lung or kidney function will be completely normal but the disease progression can be stopped in some cases. ...Read more
What specialty should I look for in a doctor to treat my wegener's granulomatosis and rheumatoid arthritis? I believe that my current rheumatologist is doing a fair job. However; the few times that I am able to actually see him and not his p.A. I feel put
Rheumatologist: You are seeing the correct physician - discuss your ambivalence with him. I agree the pa should not be your point of care. ...Read more
Serious condition: This is a very rare disease which is a form of vasculitis (inflammation of the blood vasculitis) it commonly causes, sinusitis, has associated lung nodules and is associated with varying degrees of kidney damage which can lead to kidney failures. But it is treatable, usually requiring chemotherapy (although it is not cancerous!). ...Read more