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Doctor insights on: Weaning Off Methotrexate

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Why does one have to wean off methotrexate?

Why does one have to wean off methotrexate?

Weaning is not: Necessary. The body takes 2 & 1/2 months to eliminate MTX. Stopping is enough. Weaning makes little sense! ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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I am on 20mg Methotrexate for Psoriasis for the last 10 years.Can I give it up without weaning off without side effects. Thanks?

I am on 20mg Methotrexate for Psoriasis for the last 10 years.Can I give it up without weaning off without side effects. Thanks?

Talk to derm: It is best for you to work with your doctor on getting your off of methotrexate and discuss potential options should the psoriasis recur. ...Read more

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Is it common practice to wean off plaquenil (hydroxychloroquine) for undifferentiated connective tissue disease if it didn't improve sx?Methotrexate was added & helps.

Is it common practice to wean off plaquenil (hydroxychloroquine) for   undifferentiated connective tissue disease if it didn't improve sx?Methotrexate was added & helps.

Yes: With any condition treated if a medication did not work it makes no sense to stay on it. Methotrexate is very commonly used and can be very effective as it appears to be with you. ...Read more

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Recently diagnosed with mctd. Worst symptom is red swollen painful hands. On methylpredisolone 2mg daily which helped and plaquinil. Tried to wean off steroid and ended up back on it rheumatologist wants me to start SQ methotrexate. I'm on the fence... an

Recently diagnosed with mctd. Worst symptom is red swollen painful hands. On methylpredisolone 2mg daily which helped and plaquinil. Tried to wean off steroid and ended up back on it rheumatologist wants me to start SQ methotrexate. I'm on the fence... an

Mtcd+methotrexate: hello ~ I assume your indecision, not stated, is having to take MTX is an oncological or anti-cancer drug. MTX is a very good drug (of last resort) and most Rheums wont use it unless they have to. Note that PLAQUANIL has severe side effects on the eye, making frequent eye exams mandatory if taking it. There is no good solution but a good Rheum doc will optimise Rx to LEAST harmful for BEST RESULT. ...Read more

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Is it o.K. To tan while on methotrexate?

No: While this is actually unlikely to cause problems, sunburn may be more likely while using methotrexate. Though it may depend on why and how you're using it. ...Read more

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Please describe the medication: methotrexate?

Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read more

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Is tanning ok while on methotrexate?

Is tanning ok while on methotrexate?

Yes, but: Tanning ages skin and causes cancer. But that having been said, Methotrexate does not make tanning more dangerous! ...Read more

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Do I take methotrexate for arthritis?

Do I take methotrexate for arthritis?

For inflammatory art: Methyltrexate is not use for degenerative arthritis but inflammatory arthritises like rheumatoid arthritis. ...Read more

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Can nsaids be taken with methotrexate?

Yes: NSIDs can be taken with Methotrexate. With or without Methotrexate, NSAIDs have many possible side effects and need to be used carefully. Gastrointestinal issues such as ulcers/gastritis can occur. Studies continue to show NSAIDs are associated with increased risks of cardiovascular side effects such as heart attacks and strokes. Routine labs are needed to watch for other side effects of both meds ...Read more

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What are methotrexate and fluconazole?

What are methotrexate and fluconazole?

Meds: Methotrexate is a medicine that treats several kinds of cancer, including cancer of the blood, bone, lung, breast, head, or neck. Also treats rheumatoid arthritis and psoriasis (a skin disease).

Fluconazole prevents and treats certain fungus infections. Belongs to a class of drugs called antifungals. ...Read more

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Can you take methotrexate for arthritis?

Can you take methotrexate for arthritis?

See below: Methotrexate is often prescribed for rheumatoid arthritis and some other inflammatory arthritides. It is not used for osteoarthritis. ...Read more

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Who should not take Trexall (methotrexate)?

Trexall (methotrexate): See: http://www.rxlist.com/trexall-drug/overdosage-contraindications.htm

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Can you take amoxicillin with methotrexate?

Can you take amoxicillin with methotrexate?

Yes you can....: I have never encountered a problem using these two agents together, provided your renal and hepatic functions are within normal limits. ...Read more

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Can pregnant women safely take methotrexate?

Absolutely not!: METHOTREXATE is an abortofacient! Absolute contraindication. A because of persistent metabolites called MTX polyglutamates, no attempt to get pregnant until three months after using MTX! ...Read more

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Is there a steroid component in methotrexate.

No: No steroid component in Methotrexate. In different conditions and for flares steroids are added to Methotrexate that is more of a chronic/ maintenance drug. ...Read more

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Is methotrexate in semen dangerous to ingest?

Not true: Methotrexate is not excreted in the semen in any amount that would cause a problem with swallowing semen. ...Read more

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Can methotrexate 2.5 once a week cause cancer?

Can methotrexate 2.5 once a week cause cancer?

May: Methotraxate use is known to be associated with development of lymphoma and it has a host of other side effects. Discuss the matter with your doctor and see the site below for more info.
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682019.html. ...Read more

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What is your experience with methotrexate for ra?

Good summary...: http://www.webmd.com/rheumatoid-arthritis/methotrexate-for-rheumatoid-arthritis.

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Is arava (leflunomide) cheaper then methotrexate?

Methotrexate cheaper: Generic Methotrexate is very inexpensive. If you get name brand pills it's more, but generic version of Arava (leflunomide) is more expensive than Methotrexate and Arava is the most expensive. In my experience, Methotrexate works better and has less frequent dosing (weekly instead of daily). I only use Leflunomide (arava) if Methotrexate can't be used for some reason. Side effects are similar. ...Read more

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Can you take methotrexate and fluconazole together?

Not that I know of: I don't believe there are any significant interactions between those two drugs ...Read more

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What are the uses of corticosteroid or methotrexate?

Many: Steroids are used for inflammation, rashes, prior to chemotherapy, treatment of autoimmune disorders.

Methotrexate is used for autoimmune disorders and for treatment of certain cancers. ...Read more

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What is important to know about methotrexate for ra?

What is important to know about methotrexate for ra?

Everything!: Consensus drug of first choice by the acr and eular (american & european rheumatology groups for treating moderate to severe ra. Frequently given with other drugs such as plaquenyl, sulfasalazine, or low dose prednisone. I beleve it is better to take subcutaneously, rather than oral. Should be given with folic acid. ...Read more

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Is it possible for methotrexate to change hair color?

No: No it is not. In large studies of methotrexate the number of people who reported hair color change was about 0.01%, That is not statistically significant. ...Read more

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What happens when you stop taking methotrexate for ra?

What happens when you stop taking methotrexate for ra?

Depends on your RA -: Being controlled or not. Your symptoms might get worse.
You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more

Dr. Robert Lowe
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