Doctor insights on:
Weaning Off Methotrexate
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
I am on 20mg Methotrexate for Psoriasis for the last 10 years.Can I give it up without weaning off without side effects. Thanks?
Is it common practice to wean off plaquenil (hydroxychloroquine) for undifferentiated connective tissue disease if it didn't improve sx?Methotrexate was added & helps.
Recently diagnosed with mctd. Worst symptom is red swollen painful hands. On methylpredisolone 2mg daily which helped and plaquinil. Tried to wean off steroid and ended up back on it rheumatologist wants me to start SQ methotrexate. I'm on the fence... an
Mtcd+methotrexate: hello ~ I assume your indecision, not stated, is having to take MTX is an oncological or anti-cancer drug. MTX is a very good drug (of last resort) and most Rheums wont use it unless they have to. Note that PLAQUANIL has severe side effects on the eye, making frequent eye exams mandatory if taking it. There is no good solution but a good Rheum doc will optimise Rx to LEAST harmful for BEST RESULT. ...Read more
Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read more
Yes: NSIDs can be taken with Methotrexate. With or without Methotrexate, NSAIDs have many possible side effects and need to be used carefully. Gastrointestinal issues such as ulcers/gastritis can occur. Studies continue to show NSAIDs are associated with increased risks of cardiovascular side effects such as heart attacks and strokes. Routine labs are needed to watch for other side effects of both meds ...Read more
Methotrexate is a medicine that treats several kinds of cancer, including cancer of the blood, bone, lung, breast, head, or neck. Also treats rheumatoid arthritis and psoriasis (a skin disease).
Fluconazole prevents and treats certain fungus infections. Belongs to a class of drugs called antifungals. ...Read more
Methotrexate cheaper: Generic Methotrexate is very inexpensive. If you get name brand pills it's more, but generic version of Arava (leflunomide) is more expensive than Methotrexate and Arava is the most expensive. In my experience, Methotrexate works better and has less frequent dosing (weekly instead of daily). I only use Leflunomide (arava) if Methotrexate can't be used for some reason. Side effects are similar. ...Read more
Not a good idea!: Wait!Get a more detailed answer ›
Not that I know of: I don't believe there are any significant interactions between those two drugs ...Read more
Everything!: Consensus drug of first choice by the acr and eular (american & european rheumatology groups for treating moderate to severe ra. Frequently given with other drugs such as plaquenyl, sulfasalazine, or low dose prednisone. I beleve it is better to take subcutaneously, rather than oral. Should be given with folic acid. ...Read more
Depends on your RA -:
Being controlled or not. Your symptoms might get worse.
You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more