Doctor insights on:
Waldenstrom Macroglobulinemia In Children
It is type of cancer: This condition affects your blood cells and lymph nodes. it is related to another blood cancer,called multiple myeloma.There is good treatment available for it. You will be best served by seeing a hematologist(Blood specialist) who can diagnose and treat you better. ...Read more
Paraprotein: Waldenstrom's looks like a low-grade lymphoma rather unusual plasma cells, and produces IgM pentamer molecules instead of IgG or IgA monomers or free light chains. It tends to occupy lymph nodes rather than marrow. Hyperviscosity of the blood is likely to be the most troublesome feature. ...Read more
Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.
Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more
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Perhaps: People with waldenstrom's macroglobulinemia usually go to their doctor because of lymph node enlargement. This is usually not painful. Because of the protein the lymphoma cells make, one might have a headache, shortness of breath or other symptoms. As the disease progresses, symptoms can worsen. In late stages, anemia and other low blood counts become more problematic. ...Read more
Plasmapheresis: If you have a large amount of IgM in your bloodstream and it is causing problems, for example with your nervous system, and you are offered plasmapheresis, then by all means accept it. If you are offered Rituximab or a autologous marrow transplant, get all the facts but consider these options especially if your disease progresses. ...Read more
Seek help from .....: There are many options- contact yor local chapter of the leukemia & lymphoma society or the american cancer society to get information on local oncologists at free clinics in your area. Some hospitals with cancer programs can get you in help you obtain emergency medical assistance especially if you need treatment such as state medicaid. ...Read more
What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?
50%, 90%, 100%:
Conﬁrmation of response in wm has been
adopted from response criteria for multiple
myeloma. See http://www.Iwmf.Com/docs/ghobrial_clincial_trials.Pdf
especially see tables xi, xii. The treatment of wm is aimed at control of symptomatic disease. Risk/benefits of various therapies are highly individualized based on patient and disease characteristics. ...Read more
Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?
No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more
IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more
Low grade lymphoma: It is a disorder where one produces more antibody, specifically igm. This antibody is large so when in increased numbers can lead to several problems. These include what is called hyper viscosity syndrome. As there is too much of this protein, it tends to clog small arterioles and can lead to such things as mouth sores, kidney problems and other issues. The goal is keep the level down. ...Read more
I am married in 1 year no children en problem in my health would you eat that type of food can be eat him in my husband and me?
Chocolate : This is not scientific but neither is having babies! Try anything chocolate. Eat romantic foods. Avoid alcohol and stimulants. Relax. Enjoy being married without children. The more you relax and enjoy your spouse the better your marriage will be and the more prepared you we be to be a parent. You are learning patience and you will need it! OB doctors have solutions for you when wanted ...Read more
Clobex/children: It is safe to use in kids 12 and older. Under age 12, it is a pretty hefty steroid to use for a kid. It is a steroid, and a fairly potent one at that. Kids can absorb it through their skin and it can then affect them as if they ingested it. I would use a lower potency steroid on a kid under 12, although there are occasions when a stronger one is needed - close monitoring is then needed as well ...Read more
Phoslyra is used to help reduce phosphate levels in end stage renal disease. If your child has renal disease and is working with a specialist this may be considered in the treatment plan. I would review your concerns with the MD who recommended the medication.
http://www.drugs.com/pro/phoslyra.html ...Read more
Not Recommended: Greetings. I would not recommend the use of Halonate on a child if it was not prescribed by a Dermatologist. Because it is categorized as a "super high potency" topical steriod, it can have serious side effects when used incorrectly. High potency creams and ointments can be asorbed easily through the skin and cause malfunction to certain organs. Best regards. ...Read more
Triesence is an injectable steroid into your eye to treat inflammation when steroid eye drops are not helpful. Use on a child would need to be monitored closely and be administered by an eye specialist with experience using this medication. It is not something I typically see in my practice so I suspect your child has a unique health challenge. Good luck!
http://www.drugs.com/triesence.html ...Read more
Serviflox in kids -: The answer to your question is yes and no. The medicine is ciprofloxacin. Generally we do not give this to pediatric patients because there is a risk for tendon problems in patients who have not reached full maturity. However, there are situations where the risk of this happening is outweighed by the need for the med - like in kids with Cystic Fibrosis Also, the ear drops are safe in kids! ...Read more
What condition ?: When you submit a question to the site please read it through before you send it. Understand that each question is set up individually. Your submissions are not linked. If you submit one question & a separate followup question, the followup question must have enough information to stand on it's own. ...Read more
DEPENDS: If your main interest is avoiding chromosome defects, the age is the early to mid 20's. There is a slight increase under 16 and it increases every year after the mid 20's. If your interest in being financially and emotionally ready for the work involved, the late 20's to early 40's may be better.All pregnancies have a basic risk of unexpected outcome. Reviewing risk with a geneticist helps some. ...Read more