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Doctor insights on: Waldenstrom Macroglobulinemia

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Can you tell me the main symptoms of waldenstrom macroglobulinemia?

Can you tell me the main symptoms of waldenstrom macroglobulinemia?

It is type of cancer: This condition affects your blood cells and lymph nodes. it is related to another blood cancer,called multiple myeloma.There is good treatment available for it. You will be best served by seeing a hematologist(Blood specialist) who can diagnose and treat you better. ...Read more

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Can you tell me the main symptoms of waldenstrom macroglobulinemia?

It is type of cancer: This condition affects your blood cells and lymph nodes. it is related to another blood cancer,called multiple myeloma.There is good treatment available for it. You will be best served by seeing a hematologist(Blood specialist) who can diagnose and treat you better. ...Read more

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What is the difference between multiple myeloma and Waldenstrom macroglobulinemia?

What is the difference between multiple myeloma and Waldenstrom macroglobulinemia?

Paraprotein: Waldenstrom's looks like a low-grade lymphoma rather unusual plasma cells, and produces IgM pentamer molecules instead of IgG or IgA monomers or free light chains. It tends to occupy lymph nodes rather than marrow. Hyperviscosity of the blood is likely to be the most troublesome feature. ...Read more

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Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.

Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.

Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more

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What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?

What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?

50%, 90%, 100%: Con?rmation of response in wm has been adopted from response criteria for multiple myeloma. See http://www.Iwmf.Com/docs/ghobrial_clincial_trials.Pdf especially see tables xi, xii. The treatment of wm is aimed at control of symptomatic disease. Risk/benefits of various therapies are highly individualized based on patient and disease characteristics. ...Read more

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What are the treatments for walton strom macroglobulinemia?

What are the treatments for  walton strom macroglobulinemia?

Plasmapheresis: If you have a large amount of IgM in your bloodstream and it is causing problems, for example with your nervous system, and you are offered plasmapheresis, then by all means accept it. If you are offered Rituximab or a autologous marrow transplant, get all the facts but consider these options especially if your disease progresses. ...Read more

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Are the symptoms of waldenstr_m macroglobulinemia bad?

Are the symptoms of waldenstr_m macroglobulinemia bad?

Perhaps: People with waldenstrom's macroglobulinemia usually go to their doctor because of lymph node enlargement. This is usually not painful. Because of the protein the lymphoma cells make, one might have a headache, shortness of breath or other symptoms. As the disease progresses, symptoms can worsen. In late stages, anemia and other low blood counts become more problematic. ...Read more

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I have waldenstr_m macroglobulinemia and I no longer have a doctor or insurance?

I have waldenstr_m macroglobulinemia and I no longer have a doctor or insurance?

Seek help from .....: There are many options- contact yor local chapter of the leukemia & lymphoma society or the american cancer society to get information on local oncologists at free clinics in your area. Some hospitals with cancer programs can get you in help you obtain emergency medical assistance especially if you need treatment such as state medicaid. ...Read more

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Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?

No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more