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Doctor insights on: Von Willebrand Factor Test

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Von willebrand factor effect on pregnancy?

Von willebrand factor effect on pregnancy?

Bleeding risk: Von willebrand does not affect fertility, so getting pregnant is typically not an issue. Childbirth can be challenging with von willebrand due to the increased risk for bleeding. This can be managed by a hematologist and that risk can be lowered significantly. Good luck. ...Read more

Dr. Joseph Torkildson
49 doctors shared insights

Von Willebrand (Definition)

Von Willebrand disease is caused by a deficiency of von Willebrand factor. Von Willebrand factor helps blood platelets clump together and stick to the blood vessel wall, which is necessary for normal blood clotting. There are several types ...Read more


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What is von willebrand's disease ?

What is von willebrand's disease ?

A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read more

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What is von willebrand disease?

What is von willebrand disease?

Bleeding disorder: Vwd is the most common inherited bleeding disorder. Von wiilebrand factor is a clotting protein that helps stabilize clots by helping to bind platelets together and also helps carry factor viii in the blood. In vwd, vw factor is either decreased or does not function appropriately. Clots will form but they are not stable, can easily fall apart/ dissolve, and bleeding will then occur. ...Read more

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What is von willebrand's disease?

What is von willebrand's disease?

Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read more

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What is type 3 von willebrand's disorder?

What is type 3 von willebrand's disorder?

Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read more

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Is von willebrand disease considered risky for women?

Is von willebrand disease considered risky for women?

Not necessarily: "risky" is hard to define. Because menstrual bleeding is one of the more common problems women with VWD have, it is considered "riskier" for women than men. It is very possible to manage menstrual bleeding, as well as bleeding with childbirth very effectively, however. Once that happens, VWD is no riskier for women than it is for men. ...Read more

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Can von willebrand disease interfere with getting pregnant?

Can von willebrand disease interfere with getting pregnant?

It should not: Von willebrand's disease is a condition where a deficiency or abnormality in a protein in the blood leads to an increased risk of certain types of bleeding. While it might make labor and delivery more challenging, it should not affect a woman's ability to become pregnant. ...Read more

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Does von willebrand's disease involve bruising easily?

Does von willebrand's disease involve bruising easily?

Yes: Symptoms of VWD may include increased bruising. Other types of bleeding typically seen include nose bleeds, prolonged menstrual periods, prolonged bleeding after surgery or injury, mucous membrane bleeding. Vwd usually does not present with spontaneous joint bleeding / deep tissue bleeding as is seen in the hemophilias. ...Read more

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What's the von willebrand's ddavp (desmopressin) test?

What's the von willebrand's ddavp (desmopressin) test?

Stimulaton test: Patients with type 1 VWD less vw factor than normal people. However, they store vwf normally in the cells that line their blood vessels. This can be released into the blood by certain drugs; one of these is ddavp (desmopressin). In a DDAVP (desmopressin) challenge the vwf level is measured, a dose of DDAVP (desmopressin) is given, and the level measured again to see if it goes up significantly. If so, DDAVP (desmopressin) can be used to control bleeding. ...Read more

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Is factor 7 gene mutation (heterozygote) thrombophila?

Is factor 7 gene mutation (heterozygote) thrombophila?

No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more

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Is there a genetic basis for von willebrand disease?

Is there a genetic basis for von willebrand disease?

Yes: Vwd is an inherited condition. It affects both males and females. If one parent has the most common type, type 1, then each child has a 50% chance of inheriting the disease. ...Read more

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Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Not necessarily: There are many women who get pregnant and deliver their babies without ever knowing they even have von willebrand's disease (vwd). That being said, there are many types of VWD that differ greatly in their severity. If a person has a history of VWD and has had many issues because of it, bed rest could be warranted if advised by an ob/gyn. ...Read more

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What is von willebrand's disease type 3?

VonWillebrand type 3: This is severe von willebrand disease. These people may have a total absence of von willebrand factor, and factor viii levels are often less than 10%. Usually inherited in recessive manner (one affected gene from each parent who may not have symptoms). It is essential to see a pediatric hematologist for this disease. ...Read more

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I have von willebrand disease--can a blood transfusion fix this?

I have von willebrand disease--can a blood transfusion fix this?

Unfortunately no: Von willebrand's disease is a deficiency or abnormality of a protein in the blood that helps with clotting. This is caused by a damaged gene (or genes) that are supposed to tell the body to make the correct protein. Therefore, the only way to truly cure the disease is to fix or replace the gene(s), something we can't do yet. There are effective treatments, but they don't involve blood transfusion. ...Read more

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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Is pregnancy safe with endometriosis and von willebrand's disease?

Is pregnancy safe with endometriosis and von willebrand's disease?

Not as safe as norma: Stressful pregnancies were carried with von willebrans diseases in all 3 types. Type i where factor xi is low, in ii not functioning problem is with type iii besides factor xi, viii will be low behaves like hemophilia , all types, excessive bleeding is expected, need to administer factors, to the optimal levels by experienced team ( ob, perinatologist , hematologist etc ). ...Read more

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Could people with von willebrand disease or hemophilia get tattoos?

Could people with von willebrand disease or hemophilia get tattoos?

Yes: Like everything else involving body art, it's at your own risk. Your physician might be your best guide here. If you take a factor before other procedures, this would perhaps be a good time. Start with something small. I like well-chosen body art and if this is something you've really wanted for some time, i hope you're able to get it. ...Read more

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Could people with von willebrand disease get tattoos?

Could people with von willebrand disease get tattoos?

Yes: Most people with von Willebrand's don't know they have it. If you have a severe form and are followed regularly by a hematologist, ask him/her first. Otherewise, go ahead. Be sure it's something you really and truly want. Best wishes. ...Read more

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