Doctor insights on:
Von Willebrand Diagnosis
Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.
Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more
Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read moreSee 1 more doctor answer
A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read moreSee 1 more doctor answer
VonWillebrand type 3: This is severe von willebrand disease. These people may have a total absence of von willebrand factor, and factor viii levels are often less than 10%. Usually inherited in recessive manner (one affected gene from each parent who may not have symptoms). It is essential to see a pediatric hematologist for this disease. ...Read more
Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read moreSee 1 more doctor answer
Bleeding disorder: Von willebrand disease is a condition that can cause extended or excessive bleeding. The cause of von willebrand disease is a deficiency in or impairment of a protein called von willebrand factor, an important component in your blood-clotting process. In general, it takes longer for people with von willebrand disease to form clots and stop bleeding when they're cut. ...Read more
A bleeding disorder.: It is the most common inherited bleeding disorder.Type 1 is mild , more symptomat in females with menorrhagia and mucous membrane bleeds DDAVP (desmopressin) , inhaler is effective. Type 3 severe , Joint bleeds in addition. Type 1 clotting protein is decreased but missing in type 3 and defective in type 2 ( several sub types). So the VW factor is to be given by infusion In most types 2 and 3 . ...Read more
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