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Doctor insights on: Von Wildebrand Factor

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Von willebrand factor effect on pregnancy?

Von willebrand factor effect on pregnancy?

Bleeding risk: Von willebrand does not affect fertility, so getting pregnant is typically not an issue. Childbirth can be challenging with von willebrand due to the increased risk for bleeding. This can be managed by a hematologist and that risk can be lowered significantly. Good luck. ...Read more

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What is von willebrand disease?

What is von willebrand disease?

Bleeding disorder: Vwd is the most common inherited bleeding disorder. Von wiilebrand factor is a clotting protein that helps stabilize clots by helping to bind platelets together and also helps carry factor viii in the blood. In vwd, vw factor is either decreased or does not function appropriately. Clots will form but they are not stable, can easily fall apart/ dissolve, and bleeding will then occur. ...Read more

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What is von willebrand's disease?

What is von willebrand's disease?

Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read more

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What is von willebrand's disease type 3?

What is von willebrand's disease type 3?

VonWillebrand type 3: This is severe von willebrand disease. These people may have a total absence of von willebrand factor, and factor viii levels are often less than 10%. Usually inherited in recessive manner (one affected gene from each parent who may not have symptoms). It is essential to see a pediatric hematologist for this disease. ...Read more

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Is factor 7 gene mutation (heterozygote) thrombophila?

Is factor 7 gene mutation (heterozygote) thrombophila?

No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more

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Is von willebrand disease considered risky for women?

Is von willebrand disease considered risky for women?

Not necessarily: "risky" is hard to define. Because menstrual bleeding is one of the more common problems women with VWD have, it is considered "riskier" for women than men. It is very possible to manage menstrual bleeding, as well as bleeding with childbirth very effectively, however. Once that happens, VWD is no riskier for women than it is for men. ...Read more

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Is there a genetic basis for von willebrand disease?

Yes: Vwd is an inherited condition. It affects both males and females. If one parent has the most common type, type 1, then each child has a 50% chance of inheriting the disease. ...Read more

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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What is type 3 von willebrand's disorder?

What is type 3 von willebrand's disorder?

Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read more

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Does von willebrand's disease involve bruising easily?

Does von willebrand's disease involve bruising easily?

Yes: Symptoms of VWD may include increased bruising. Other types of bleeding typically seen include nose bleeds, prolonged menstrual periods, prolonged bleeding after surgery or injury, mucous membrane bleeding. Vwd usually does not present with spontaneous joint bleeding / deep tissue bleeding as is seen in the hemophilias. ...Read more

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What is von willebrand's disease ?

What is von willebrand's disease ?

A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read more

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Is there a genetics connection von hippel-lindau disease?

Is there a genetics connection von hippel-lindau disease?

Von Hippel-Lindau: Von hippel-lindau syndrome is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. Tumors may be either noncancerous or cancerous and usually appear during young adulthood; however, the signs and symptoms of von hippel-lindau syndrome can occur throughout life. ...Read more

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How common is von hippel-lindau disease?

How common is von hippel-lindau disease?

Von Hippel-Lindau: Von hippel-lindau syndrome is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. Tumors may be either noncancerous or cancerous and usually appear during young adulthood; however, the signs and symptoms of von hippel-lindau syndrome can occur throughout life. ...Read more

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Could people with von willebrand disease or hemophilia get tattoos?

Could people with von willebrand disease or hemophilia get tattoos?

Yes: Like everything else involving body art, it's at your own risk. Your physician might be your best guide here. If you take a factor before other procedures, this would perhaps be a good time. Start with something small. I like well-chosen body art and if this is something you've really wanted for some time, i hope you're able to get it. ...Read more

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Can people with von willebrand's disease play tackle football?

Can people with von willebrand's disease play tackle football?

Ask hematologist: This is a decision that you should make with your hematologist. There is not a one-size-fits-all answer for this one. Vwd is a variable disorder with different levels of bleeding between different patients and subtypes of the disease. ...Read more

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Is leiden factor v genetic?

Is leiden factor v genetic?

Yes: Factor v leiden is a genetic condition. If you have one copy of a fvl mutation, you are heterozygous with an increased risk of blood clotting. If you have 2 copies you are homozygous with an even higher risk of clotting. The inheritence pattern is simple mendelian genetics. You get one copy of the gene from your mother and one from your father. ...Read more

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Is hemophilia a gene mutation?

Yes: Both hemophilia a and b are due to mutations in genes on the x chromosome. ...Read more

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Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Should a person with factor xiii von willebrands disease thats pregnant go on bedrest?

Not necessarily: There are many women who get pregnant and deliver their babies without ever knowing they even have von willebrand's disease (vwd). That being said, there are many types of VWD that differ greatly in their severity. If a person has a history of VWD and has had many issues because of it, bed rest could be warranted if advised by an ob/gyn. ...Read more