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Doctor insights on: Vip Chemotherapy

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

Dr. Devon Webster
974 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more


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Chemotherapy hormone receptor positive node breast cancer?

Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

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Why etoposide administered before ifosfamide in chemotherapy ?

Why etoposide administered before ifosfamide in chemotherapy ?

NO SPECIFIC REASON: Here are 3 possible reasons: 1) Most clinical trials use this sequence, although it has been given after in other studies as well 2) Etoposide is a shorter infusion 1-2 hours, Ifosfamide typically hours to 24 hrs, requiring monitoring of urine 3) Giving etoposide 1st also allows opportunity to give IV hydration prior to ifosfamide ...Read more

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Rise in psa after radiation and hormone treatment?

Not enough info: You describe a complex situation that requires complete review of the medical record. Questions that need to be answered include: - cancer grade - psa at diagnosis - rate of psa rise - stage, ?Mets? - duration of hormones - how long since radiation... See your urologist or radiation oncologist and ask them all of your questions. If you don't feel comfortable with them, seek another opinion. ...Read more

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Zytiga (abiraterone acetate) or xtandi for pre-chemo castration resistant prostate cancer? Thoughts?

Zytiga (abiraterone acetate) or xtandi for pre-chemo castration resistant prostate cancer? Thoughts?

Good options: Both are good options. It will depend on safety profiles and the need of using steroid with zytiga (abiraterone acetate) but not for extandi. Discuss further with your oncologist to select which one is the best for you. ...Read more

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Breast cancer chemotherapy in hepatitis b patients?

Breast cancer chemotherapy in hepatitis b patients?

Challenging : Appropriate involvement of hepatologist and treatment (or prophylaxis) of hep b is imperative. ...Read more

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How effective r chemotherapy uft pills in metastic colon cancer?

How effective r chemotherapy uft pills in metastic colon cancer?

Some response: meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more

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Can adriamycin (doxorubicin) (chemo) cause neuropathy?

Can adriamycin (doxorubicin) (chemo) cause neuropathy?

Yes: Doxorubicin (adriamycin (doxorubicin)) can indeed cause nerve damage, but not always the typical 'peripheral neuropathy' seen with other chemotherapy drugs. It affects the myelin sheath of nerve and ganglia and can cause 'ganglionopathy'. Symptoms include numbness/tingling in both the arms/hands and legs/feet (not just the feet). Other drugs given alongside adriamycin (doxorubicin) can add to the risk. ...Read more

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Hormone therapy for prostate cancer?

Hormone therapy for prostate cancer?

Treatment: Hormone therapy consists of medications that decrease the effects of testosterone on prostate cancer and a man's body. Prostate cancer growth is primarily fueled by testosterone. If testosterone is absent/ineffective, prostate cancer hopefully would stop growing. Hormone therapy has several varieties including pills and injections. Given for advanced disease or at times prior to radiation. ...Read more

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Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more

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Is herceptin (trastuzumab) effective in treating bowel cancer?

No: There is no evidence that Herceptin (trastuzumab) is useful in treating colon cancer. It' s use has been expanded to patients with metastatic esophageal and stomach cancers who over express the her2 protein ...Read more

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What about neuroendocrine (islet cell tumors)?

What about neuroendocrine (islet cell tumors)?

Interesting tumor: Overally, neuroendocrine tumors are often capable of over-producing hormones that your body naturally makes. Islet cells are cells that are naturally present in the pancreas and produce a number of hormones, most notably insulin. Insulin helps you break down and digest sugars. Patients with an islet cell tumor can produce too much Insulin resulting in weight & gain and low blood sugars. ...Read more

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Diagnoged with cutaneous tcell lymphoma .Treated with eletron beam.Interferon, gemcitabine, anthracycline, etoposide, procarbazine without improv.I'm 64 y?

Diagnoged with cutaneous tcell lymphoma .Treated with eletron beam.Interferon, gemcitabine, anthracycline, etoposide, procarbazine without improv.I'm 64 y?

There are new agents: There are several new agents for this disease. It is uncommon and you need a good assessment of the status of both your disease and your ability to take treatment. There are oral agents, antibodies, drugs like velcade (bortezomib) that might be helpful. I would suggest an evaluation by an oncologist who is familiar with this disease. ...Read more

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For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

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What is adjuvant chemo?

What is adjuvant chemo?

Adjuvant chemo: Adjuvant chemo is chemotherapy that is given after curative surgical resection of a cancer. It is given to reduce risk of recurrence of cancer. ...Read more

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Can Radiotherapy be used for metastic colon cancer if chemotherapy is resistant ?

Can
Radiotherapy be used for metastic colon cancer if chemotherapy is resistant ?

Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read more

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Are cea markers reliable for metastic colon cancer ?

Are cea markers reliable for metastic colon cancer ?

Depending how used: CEA first identified in 1965 by Phil Gold and Samuel O. Freedman in human colon cancer extracts. Thought to be valuable for dx colorectal Ca but the glycoprotein is also expressed in inflamed tissue so that smoking and enema can cause rise. Best used for monitoring so that if present in primary and rises it represents treatment failure and if diminishes during treatment it represents a response. ...Read more

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Colon cancer chemo necessary?

Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

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What is normal tt levels ib a 45 male, how do you test why one had low tt? Vip

What is normal  tt levels ib a 45 male, how do you test why one had low tt? Vip

Tt= testosterone?: If you're asking what is a normal testosterone for a 45 year old male it's dependent on the lab but somewhere between 300-1000. You need to know the free testosterone also and it should be checked in the morning. Don't go on replacement without knowing the downstream effects. For more: www.Peedoc.Com @thepeedoc. ...Read more

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Where is the vip muscle. How do I locate it. And what are some excersices to make it stronger?

Where is the vip muscle. How do I locate it. And what are some excersices to make it stronger?

VIP muscle?: I know and work with every significant muscle for pain and strengthening for rehab and do not know of a "vip" muscle. Could it be slang for another muscle? ...Read more

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Last night i had a servere nightmare about being pursued by a large black vip car with blacked out windows. What could this mean?

Last night i had a servere nightmare about being pursued by a large black vip car with blacked out windows. What could this mean?

Interpreting Dreams: Interpreting dreams is tricky business. One person's idea about the meaning of a dream may be totally different from the next person. Thus, guessing what this means, would be-meaningless. What do you think it means? If someone asked you this, how would you respond? I have seen websites which interpret dreams, otherwise-i am not sure we healthtappers are going to be of much help. I could be wrong. ...Read more

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What test would you do to diagnosis vipoma? 1 high VIP & chromogranin, hypok be enough to confirm ? How long does diagnosis take?

VIPoma: This is complicated. You may not have the satisfaction of "a diagnosis" until your doctors have found a tumor, removed it and the symptoms have resolved. As I mentioned to you before, you should be seeing someone who specializes in these kinds of tumors. Good luck. ...Read more

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One high VIP blood test one normal. Was told VIP can fluctuate & retested when symptomatic. Is this the only way they can officially diagnose VIPOMA?

One high VIP blood test one normal. Was told VIP can fluctuate & retested when symptomatic. Is this the only way they can officially diagnose VIPOMA?

VIPoma: Presumably you have the cardinal symptoms and signs: watery diarrhea and low K. Yes, plasma VIP should be measured during symptoms, and it should be high. If this is a VIPoma or other neuroendocrine tumor, then it becomes important to localize it. CT/MRI/somatostatin receptor imaging. Most important: go to a center that specializes in this. These are rare, and average doc doesn't see much. ...Read more

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What's vasoactive intestinal polypeptide vip?

What's vasoactive intestinal polypeptide vip?

VIP definition: Vasoactive intestinal peptide or vip is a peptide hormone containing 28 Amino Acid residues. Vip is produced in many tissues of vertebrates including the gut, pancreas and suprachiasmatic nuclei of the hypothalamus in the brain. Vip stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea & stomach. ...Read more

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My boyfriend is go through chemo BEP/VIP could I accidentally get pregnant ?

Unclear question: BF getting chemo does not make GF pregnant. If you have unprotected sex, you could get pregnant. If you do not wish to get pregnant, use contraception every time, all the time. ...Read more

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Does vip (vasoactive intestinal peptides) have to be out on ice imediately. If done incorrect would you get false high or low?

Does vip (vasoactive intestinal peptides) have to be out on ice imediately. If done incorrect would you get false high or low?

If it's going to be: Stored it needs to be kept on ice then frozen. However, once the blood is drawn, it is always better for it to be put on ice. What actually disturbs the results, could be the technique used in the washing, essentially the "lab" section. Most of the time the lab techs have done this for years and are capable of producing good results. If you are not satisfied, have it repeated. ...Read more

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Can untreated gitelman syndrome (diagnosing now) cause a false positive on a VIP, 5hiaa & chromogranin test? 1 positive, 3 negatives for each.

Can untreated gitelman syndrome (diagnosing now) cause a false positive on a VIP, 5hiaa & chromogranin test? 1 positive, 3 negatives for each.

No: Hi. Gitelman's is a genetic disease of a salt transporter in the kidney tubule. VIP, 5-HIAA, and chromogranin A are all products of neuroendocrine cells. There is no relation between Gitelman's and neuroendocrine tissue. If one patient has all that going on, it's happenstance. ...Read more

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What type of tumors could cause numbness on left side of body? A lot in middle night. High vip, high chromogranin, hypok, dehydration. Undiagnosed!

What type of tumors could cause numbness on left side of body? A lot in middle night. High vip, high chromogranin, hypok, dehydration. Undiagnosed!

Hypokalemia: Do you have high blood pressure ? Low potassium and Dehydration can produce weakness and numbness. If you have hypertension and if you have persistent hypokalemia, you should be evaluated for hyperaldosteronism. High VIP and high chromogranin are signs of neuron doctrine rumors ...Read more

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Can Renal cyst cause hight chromogranin and high vip levels? Also hypoK and dehydration.

Can Renal cyst cause hight chromogranin  and high vip levels? Also hypoK and dehydration.

No and maybe: Hi. Neither renal cysts nor tumors cause high chromogranin A nor high VIP. If the cyst is not a cyst, but a tumor, it could cause hypokalemia. Dehydration would be more likely due to the high VIP (which IS related to high chromogranin A), and the secretory diarrhea it causes. Renal cyst is probably a red herring. ...Read more

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Had VIP chemo for stage 3 testicular, hCG at 43 tumors are smaller. Pet scan no intense hits. Alphaf normal. Cause for hCG levels higher?

Had VIP chemo for stage 3 testicular, hCG at 43 tumors are smaller. Pet scan no intense hits. Alphaf normal. Cause for hCG levels higher?

Not an easy situatio: It is hard to assess your complex situation through few lines, but VIP is usually given as a second line chemotherapy for testicular cancer mostly in the salvage setting. Persistent tumor marker is usually a sign of persistent disease and you need a thorough. Evaluation by a GU medical oncologist and preferably in a multidisciplinary setting ...Read more

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I am 26weeks pregnancy my ths is 0.34 i take 100mcg.And my baby fetal heart rate 145/min and my hemoglobin 9.2gms%.I take macal vip 500mg in daly 2 ?

I am 26weeks pregnancy my ths is 0.34 i take 100mcg.And my baby fetal heart rate 145/min and my hemoglobin 9.2gms%.I take macal vip 500mg in daly 2 

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D/w your doctor : Follow up with your doctor/ob- you need to have your iron and folate (folic acid) level checked and if they are low- definitely need to get replacement. Your thyroid medication dose may also need to be adjusted down slightly. Also, you need to take prenatal multivitamin one a day. I don't know what is inside the macal vip- but i assume it is vit c mainly. Discuss further with your ob. ...Read more

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Endo tumor symptoms fluctuate? One day I'll be fine next day hypoK, numbness, chills, back ache, cramping. Undiagnosed but high vip & chromogranin.

Endo tumor symptoms fluctuate? One day I'll be fine next day hypoK, numbness, chills, back ache, cramping. Undiagnosed but high vip & chromogranin.

VIPoma?: Hi. Does your endo or GI doc think this is a VIPoma? Those are very rare, and at your age would make a genetic syndrome more likely. How high are the VIP and CgA? They need to be several FOLD elevated above the upper limit of normal to suspect VIPoma. Is the diagnosis beyond question? They can be very difficult to localize. I assume no luck with that. Somatostatin analog drugs can help symptoms. ...Read more

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Could you have Vipoma w/ out diarrhea? I have had low pottasium, numbness, weakness, hot flashes, high vip test, temp paralysis, low heart rate, dehyd

Could you have Vipoma w/ out diarrhea? I have had low pottasium, numbness, weakness, hot flashes, high vip test, temp paralysis, low heart rate, dehyd

It comes and goes: VIP levels and diarrhea fluctuate. This is an uncommon condition best managed with a team approach. Adrenal insufficiency and other conditions that cause diarrhea have by now been excluded I would assume. You should have a good talk with your gastroenterologist about what to expect. ...Read more

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What would come to mind? HypoK, dehydration, hot flashes, no period, weakness, abdominal cramps, hot flashes, numbness, high vip & chromogranin

What would come to mind? HypoK, dehydration, hot flashes, no period, weakness, abdominal cramps, hot flashes, numbness, high vip &  chromogranin

VIP dehydration: sounds like hypokalemic rhabdomylosis due to an endocrine secreting tumor Unusual for your age but pheochromocytoma would be high on my list. Any issues with facial flushing or high BP?? Additional testing including urine for 24 hours should be done. Your doctor needs to run these tests to exclude a pheo. good luck ...Read more

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My bf oncologist is not a specialist for eye/brain. What is the best method to rid the cancer if BEP/VIP chemo doesn't work. 2 in brain 1 in eye?

My bf oncologist is not a specialist for eye/brain. What is the best method to rid the cancer if BEP/VIP chemo doesn't work. 2 in brain 1 in eye?

Always get a 2nd: opinion when in doubt, and ask your pediatrician these questions first. You have to be over 16 to post questions here. So do ask your doctor, or have him ask his pediatrician. ...Read more

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Hypok vs periodic paralysis? Endo tumor have fluctuations in potassium or consistently low? High vip & chromogranin, hypok, dehydration, numbness

Hypok vs periodic paralysis? Endo tumor have fluctuations in potassium or consistently low?  High vip & chromogranin, hypok, dehydration, numbness

HypoK: If you are losing so much K consistently, you should probably be on K supplements. Overall, however, you have a complicated medical condition and you should not be getting day to day medical advice from a blog. Please see your doctor, and if necessary go to a specialty center for diagnosis or treatment. ...Read more

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What does vasoactive intestinal peptide do?

What does  vasoactive intestinal peptide do?

Messenger proteins: These proteins are released by nerve endings in the intestines. They can cause the muscle walls of organs and blood vessels to relax . For example, they help the muscle band in the lower esophagus to open up and pass food into the stomach, and can increase blood flow in the intestines. They also stimulate secretions. Tumors that produce large amounts of vip cause severe diarrhea. ...Read more