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Doctor insights on: Vincristine Drug Cold Be Fatal To Cell

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How can vincristine and doxorubicin be fatal to a cell?

How can vincristine and doxorubicin be fatal to a cell?

They are/Bind to nuc: They bind to nuclear elements and stop dna synthesis which leads to cell death. ...Read more

Dr. Barbara Lavi
13 doctors shared insights

Vincasar Pfs (Definition)

Vincasar PFS is a cell division inhibitor which is a ...Read more


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What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

Both drugs: Are . 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff. ...Read more

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Why would vincristine (oncovin) be fatal?

Why would vincristine (oncovin) be fatal?

Used correctly - no: Vincristine is an anti-cancer drug and has been used for over 50 years in cancer treatment. Given by an experienced health care worker fatalities are extremely rare (I have not experienced nor heard about anyone confronting this problem. ...Read more

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Why does the drug vincristine have side effects?

Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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How can the chemo therapy drug vincristine be harmful?

How can the chemo therapy drug vincristine be harmful?

Neuropathic effects: Are most common with vincristine. Patients can experience pain, numbness, tingling (aka paresthesias), difficulty with chewing/jaw pain, foot drop and discoordination. Gabapentin and physical therapy may help wth these. Also a neuropathic complication, constipation is a significant concern since hard stools predispose to serious bacterial infection. Liver toxicity can be an issue also. ...Read more

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Can vascular tumors in infants be treated with a drug called vincristine?

Can vascular tumors in infants be treated with a drug called vincristine?

Yes: There are many types of vascular malformations that present during infancy. Some spontaneously regress, other require intervention. For certain vascular tumors, vincristine could be indicated. It depends on the type of tumor and the size and location of it. Other treatments include embolization, or other drugs such as steroids or propranolol. ...Read more

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What is the drug vincristine used for?

What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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Why vincristine is one of the most used cancer drug?

Why vincristine is one of the most used cancer drug?

While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas. It does not work very well in most adult solid tumors. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

Dr. Stephen Hunger
630 doctors shared insights

Vincristine (Definition)

Vincristine is a cell division inhibitor which is a ...Read more


Dr. Milton Alvis Jr
12 doctors shared insights

Oncovin (Definition)

Oncovorin is a cell division inhibitor which is a ...Read more