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Doctor insights on: Vincristine Drug Cold Be Fatal To Cell

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How can vincristine and doxorubicin be fatal to a cell?

How can vincristine and doxorubicin be fatal to a cell?

They are/Bind to nuc: They bind to nuclear elements and stop dna synthesis which leads to cell death. ...Read more

Dr. Corey Clay
13 Doctors shared insights

Vincasar Pfs (Definition)

Vincasar PFS is a cell division inhibitor which is a ...Read more


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What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

Both drugs: Are. 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff. ...Read more

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Why would vincristine (oncovin) be fatal?

Why would vincristine (oncovin) be fatal?

Used correctly - no: Vincristine is an anti-cancer drug and has been used for over 50 years in cancer treatment. Given by an experienced health care worker fatalities are extremely rare (I have not experienced nor heard about anyone confronting this problem. ...Read more

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Why does the drug vincristine have side effects?

Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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How can the chemo therapy drug vincristine be harmful?

How can the chemo therapy drug vincristine be harmful?

Neuropathic effects: Are most common with vincristine. Patients can experience pain, numbness, tingling (aka paresthesias), difficulty with chewing/jaw pain, foot drop and discoordination. Gabapentin and physical therapy may help wth these. Also a neuropathic complication, constipation is a significant concern since hard stools predispose to serious bacterial infection. Liver toxicity can be an issue also. ...Read more

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Can vascular tumors in infants be treated with a drug called vincristine?

Can vascular tumors in infants be treated with a drug called vincristine?

Maybe: Vincristine is approved for use in pediatric patients. Depending on the type of tumor this drug may be beneficial. ...Read more

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What is the drug vincristine used for?

What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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Why vincristine is one of the most used cancer drug?

Why vincristine is one of the most used cancer drug?

While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas. It does not work very well in most adult solid tumors. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard (old/conventional treatments). If the new treatment if better (more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

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Does the drug vincristine cause blood clots in the bowel, grandad had rcvp them had a blood clot in the major artery supplying the bowel?

Does the drug vincristine cause blood clots in the bowel, grandad had rcvp them had a blood clot in the major artery supplying the bowel?

I suspect this was..: True...True and unrelated. Coagulopathy, is not a side effect of vincristine. However, having a cancer (such as lymphoma that I suspect your dad has) can elevate clotting risk all by itself. Prednisone in rcvp can elevate risk of clotting as well. Additionally, as a 67yo man, he could have had pre-existing vascular disease that elevated his risk for clotting in those vessels that supply the gut. ...Read more

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How effective is Vincristine for treating leukemia?

How effective is Vincristine for treating leukemia?

Which Leukemia type?: Vincristine is very effective in one type called Acute Lymphoblastic Leukemia (ALL). it is typicalyd used in combination with other chemotherapy agents/drugs. ...Read more

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Which is more prefered vincristine or vinblastin sulfate?

Which is more prefered vincristine or vinblastin sulfate?

They are in the same: Class but not interchangeable. Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief. ...Read more

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Why does vincristine have side effects like nerve problems?

Why does vincristine have side effects like nerve problems?

Microtubules!: Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) but microtubules ALSO transport chemicals inside our nerve cells. The longest nerves in our body connect our spinal cord to our fingertips and toes ; this is why vincristine causes nerve problems especially in fingertips and toes. ...Read more

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I am getting vincristine and dactinomycin andi want to lessen the side effects?

I am getting vincristine and dactinomycin andi want to lessen the side effects?

These remain: Cornerstone drugs in wilms tumor and other pediatric tumors. All drugs have side effects. Speak to your oncologist about which one bothers you the most. The usual answer is dose reduction or substitution of another drug...Neither good options. ...Read more

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Alts to vincristine?

Alts to vincristine?

Depends on cancer: Alternative to vincristine -will depend on the type of cancer. Different cancer has different treatment. Please discuss with your oncologist in detail about your options etc. Good luck. ...Read more

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How is vincristine used?

How is vincristine used?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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What does vincristine do?

What does vincristine do?

Vincristine. ..: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons. ...Read more

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Alternatives to vincristine?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine. ...Read more

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What is vincristine used for?

What is vincristine used for?

Chemo agent: Vincristine is a chemotherapeutic agent also known as Oncovin (vincristine). It is primarily employed in the treatment of lymphomas and Hodgkins disease, usually in combination with other drugs such as in CHOPP. Side effects include nausea, hair loss and neurologic loss of balance. It works partly by binding to the tubulin protein, stopping the cell from separating its chromosomes during metaphase ...Read more

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Can vincristine cause anemia?

Can vincristine cause anemia?

Anything is possible: But the manner in which we use vincristine in typical chemotherapy regimens is not myelosuppressive. You are far more likely to experience its neuropathic side effects, such as pain, parenthesis, foot drop, jaw pain, constipation, etc. Anemia, at least as a consequence of marrow hypofunction, would be highly unlikely, so much so that I would look for another cause. ...Read more

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Why is vincristine used to treat some cancer patients?

Why is vincristine used to treat some cancer patients?

Vincristine: Vincristine is a chemo drug that is used as it targets cells that are rapidly dividing...like hair, lining of your gut, bone marrow, and of course cancer cells. ...Read more

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I have leukaemia, im on vincristine infusions monthly, plus 6-mp daily, my girlfriend is being treated using mutalane, could kissing be dangerous?

I have leukaemia, im on vincristine infusions monthly, plus 6-mp daily, my girlfriend is being treated using mutalane, could kissing be dangerous?

Possibly: Chemotherapy drugs and their metabolites can be detected in bodily fluids including saliva. Prolonged contact with saliva of someone on chemo could therefore expose the other person to the drugs. The half lives of the IV drugs are usually fairly short, but the oral drugs, like 6-mp will be present all the time when you are taking them. Although the risk is low, chemo drugs can cause cancers. ...Read more

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What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

Join support group: You are undergoing the toughest part, and a cancer support group would ease your mind/spirit. Meditation, visualization exercises can also ease the pain, as having acupuncture done to relieve any nausea associated with treatment. Doing chair yoga to stretch your muscles may help. Also, if it's there's any stomatitis, sometimes Nystatin popsicles are helpful. Depends what type of pain you're having. ...Read more

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Can small doses of vincristine make my hair fall out?

Vincristine.: Please go to "Wikipedia" on the web and learn about Vincristine.
It is an important drug and regrettably have an effect on your hair.

Check with your doctor about the possibility of hair loss taking vincristine but don't stop that drug! ...Read more

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What can be done with vincristine or vinblastine to treat encephalopathy?

What can be done with vincristine or vinblastine to treat encephalopathy?

Nothing useful: These drugs are used for treatment of Cancer in many parts of the body. They have No use for treating encephlitis.. ...Read more

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Please tell me what can be done with vincristine or vinblastine encephalopathy?

Your doctor can addr: This should be addressed by your doctor. I need to know more about the circumstances which lead to this problem. It is not a condition which happens easily unless there was an accidental overdose of medication (vincristine, more often than vinblastine).
Is the affected person functional or non functional due to encephalopathy? Tell me some more. ...Read more

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How much time does it take to lose hair after chemo my daughter is getting vincristine?

How much time does it take to lose hair after chemo my daughter is getting vincristine?

Hair loss: Hair loss from vincristine treatment can begin within the first few days of tratment. Hairloss is reversible after treatment is over ...Read more

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My recent I.T. Procedure and triple dose of vincristine, methotrexate, and mercaptopurine gives me a strong headache when not lying down. Why?

My recent I.T. Procedure and triple dose of vincristine, methotrexate, and mercaptopurine gives me a strong headache when not lying down. Why?

Spinal headache: Spinal headaches can occur after lumbar punctures and are associated with headache when standing. They usually resolve after a few days, but occasionally persist due to leakage of CSF from the puncture site. Our practice is to treat these with IV caffeine and IV hydration and if not better then rarely our anesthesiologist places a "blood bandage" using the patient's blood to plug the hole. ...Read more

Dr. Stephen Hunger
630 Doctors shared insights

Vincristine (Definition)

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Dr. Gregory Moneta
12 Doctors shared insights

Oncovin (Definition)

Oncovorin is a cell division inhibitor which is a ...Read more