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Vincristine Drug Cold Be Fatal To Cell
Both drugs: Are . 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff. ...Read moreSee 1 more doctor answer
Any ideas why the drug vincristine have side effects such as loss of dividing cells an nerve problems?
Mitochondria: it works on mitochondriaGet a more detailed answer ›
Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read moreSee 1 more doctor answer
It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read moreSee 1 more doctor answer
Neuropathic effects: Are most common with vincristine. Patients can experience pain, numbness, tingling (aka paresthesias), difficulty with chewing/jaw pain, foot drop and discoordination. Gabapentin and physical therapy may help wth these. Also a neuropathic complication, constipation is a significant concern since hard stools predispose to serious bacterial infection. Liver toxicity can be an issue also. ...Read moreSee 1 more doctor answer
While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas. It does not work very well in most adult solid tumors. ...Read moreSee 1 more doctor answer
Yes: There are many types of vascular malformations that present during infancy. Some spontaneously regress, other require intervention. For certain vascular tumors, vincristine could be indicated. It depends on the type of tumor and the size and location of it. Other treatments include embolization, or other drugs such as steroids or propranolol. ...Read moreSee 1 more doctor answer
Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?
Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more
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