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Doctor insights on: Vincristine Drug Cold Be Fatal To Cell

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How can vincristine and doxorubicin be fatal to a cell?

How can vincristine and doxorubicin be fatal to a cell?

They are/Bind to nuc: They bind to nuclear elements and stop dna synthesis which leads to cell death. ...Read more

Dr. Amanda Itzkoff
13 doctors shared insights

Vincasar Pfs (Definition)

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What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

What is the action of vincristine and doxorubicin and why can they be fatal to a cell?

Both drugs: Are . 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff. ...Read more

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Why would vincristine (oncovin) be fatal?

Why would vincristine (oncovin) be fatal?

Used correctly - no: Vincristine is an anti-cancer drug and has been used for over 50 years in cancer treatment. Given by an experienced health care worker fatalities are extremely rare (I have not experienced nor heard about anyone confronting this problem. ...Read more

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Why does the drug vincristine have side effects?

Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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How can the chemo therapy drug vincristine be harmful?

How can the chemo therapy drug vincristine be harmful?

Neuropathic effects: Are most common with vincristine. Patients can experience pain, numbness, tingling (aka paresthesias), difficulty with chewing/jaw pain, foot drop and discoordination. Gabapentin and physical therapy may help wth these. Also a neuropathic complication, constipation is a significant concern since hard stools predispose to serious bacterial infection. Liver toxicity can be an issue also. ...Read more

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What is the drug vincristine used for?

What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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Why vincristine is one of the most used cancer drug?

Why vincristine is one of the most used cancer drug?

While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas. It does not work very well in most adult solid tumors. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

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Does the drug vincristine cause blood clots in the bowel, grandad had rcvp them had a blood clot in the major artery supplying the bowel?

Does the drug vincristine cause blood clots in the bowel, grandad had rcvp them had a blood clot in the major artery supplying the bowel?

I suspect this was..: True...True and unrelated. Coagulopathy, is not a side effect of vincristine. However, having a cancer (such as lymphoma that i suspect your dad has) can elevate clotting risk all by itself. Prednisone in rcvp can elevate risk of clotting as well. Additionally, as a 67yo man, he could have had pre-existing vascular disease that elevated his risk for clotting in those vessels that supply the gut. ...Read more

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How effective is Vincristine for treating leukemia?

How effective is Vincristine for treating leukemia?

Which Leukemia type?: Vincristine is very effective in one type called Acute Lymphoblastic Leukemia(ALL). it is typicalyd used in combination with other chemotherapy agents/drugs. ...Read more

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Which is more prefered vincristine or vinblastin sulfate?

Which is more prefered vincristine or vinblastin sulfate?

They are in the same: Class but not interchangeable. Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief. ...Read more

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Why does vincristine have side effects like nerve problems?

Why does vincristine have side effects like nerve problems?

Microtubules!: Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) but microtubules ALSO transport chemicals inside our nerve cells. The longest nerves in our body connect our spinal cord to our fingertips and toes ; this is why vincristine causes nerve problems especially in fingertips and toes. ...Read more

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I am getting vincristine and dactinomycin andi want to lessen the side effects?

I am getting vincristine and dactinomycin andi want to lessen the side effects?

These remain: Cornerstone drugs in wilms tumor and other pediatric tumors. All drugs have side effects. Speak to your oncologist about which one bothers you the most. The usual answer is dose reduction or substitution of another drug...Neither good options. ...Read more

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Alts to vincristine?

Alts to vincristine?

Depends on cancer: Alternative to vincristine -will depend on the type of cancer. Different cancer has different treatment. Please discuss with your oncologist in detail about your options etc. Good luck. ...Read more

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How is vincristine used?

How is vincristine used?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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What does vincristine do?

What does vincristine do?

Vincristine ...: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons. ...Read more

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Alternatives to vincristine?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine. ...Read more

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What is vincristine used for?

What is vincristine used for?

Chemo agent: Vincristine is a chemotherapeutic agent also known as Oncovin (vincristine). It is primarily employed in the treatment of lymphomas and Hodgkins disease, usually in combination with other drugs such as in CHOPP. Side effects include nausea, hair loss and neurologic loss of balance. It works partly by binding to the tubulin protein, stopping the cell from separating its chromosomes during metaphase ...Read more

Dr. Stephen Hunger
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Vincristine (Definition)

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Dr. Corey Clay
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Oncovin (Definition)

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