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Doctor insights on: Vincristine

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Dr. Stephen Hunger
630 doctors shared insights

Vincristine (Overview)

Vincristine is a cell division inhibitor which is a kind of cancer drug.


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What does vincristine do?

What does vincristine do?

Vincristine ...: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons. ...Read more

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Dr. Stephen Hunger
630 doctors shared insights

Vincristine (Overview)

Vincristine is a cell division inhibitor which is a kind of cancer drug.


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What is the drug vincristine used for?

What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

Join support group: You are undergoing the toughest part, and a cancer support group would ease your mind/spirit. Meditation, visualization exercises can also ease the pain, as having acupuncture done to relieve any nausea associated with treatment. Doing chair yoga to stretch your muscles may help. Also, if it's there's any stomatitis, sometimes Nystatin popsicles are helpful.Depends what type of pain you're having. ...Read more

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How can the chemo therapy drug vincristine be harmful?

How can the chemo therapy drug vincristine be harmful?

Neuropathic effects: Are most common with vincristine. Patients can experience pain, numbness, tingling (aka paresthesias), difficulty with chewing/jaw pain, foot drop and discoordination. Gabapentin and physical therapy may help wth these. Also a neuropathic complication, constipation is a significant concern since hard stools predispose to serious bacterial infection. Liver toxicity can be an issue also. ...Read more

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Why does the drug vincristine have side effects?

Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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How much time does it take to lose hair after chemo my daughter is getting vincristine?

How much time does it take to lose hair after chemo my daughter is getting vincristine?

Hair loss: Hair loss from vincristine treatment can begin within the first few days of tratment. Hairloss is reversible after treatment is over ...Read more

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Alts to vincristine?

Alts to vincristine?

Depends on cancer: Alternative to vincristine -will depend on the type of cancer. Different cancer has different treatment. Please discuss with your oncologist in detail about your options etc. Good luck. ...Read more

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How is vincristine used?

How is vincristine used?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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What does vincristine do?

Vincristine ...: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons. ...Read more

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Alternatives to vincristine?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine. ...Read more

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What is vincristine used for?

What is vincristine used for?

Chemo agent: Vincristine is a chemotherapeutic agent also known as Oncovin (vincristine). It is primarily employed in the treatment of lymphomas and Hodgkins disease, usually in combination with other drugs such as in CHOPP. Side effects include nausea, hair loss and neurologic loss of balance. It works partly by binding to the tubulin protein, stopping the cell from separating its chromosomes during metaphase ...Read more

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What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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Why would vincristine (oncovin) be fatal?

Why would vincristine (oncovin) be fatal?

Used correctly - no: Vincristine is an anti-cancer drug and has been used for over 50 years in cancer treatment. Given by an experienced health care worker fatalities are extremely rare (I have not experienced nor heard about anyone confronting this problem. ...Read more

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Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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How effective is Vincristine for treating leukemia?

How effective is Vincristine for treating leukemia?

Which Leukemia type?: Vincristine is very effective in one type called Acute Lymphoblastic Leukemia(ALL). it is typicalyd used in combination with other chemotherapy agents/drugs. ...Read more

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Which is more prefered vincristine or vinblastin sulfate?

Which is more prefered vincristine or vinblastin sulfate?

They are in the same: Class but not interchangeable. Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief. ...Read more

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Why does vincristine have side effects like nerve problems?

Why does vincristine have side effects like nerve problems?

Microtubules!: Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) but microtubules ALSO transport chemicals inside our nerve cells. The longest nerves in our body connect our spinal cord to our fingertips and toes ; this is why vincristine causes nerve problems especially in fingertips and toes. ...Read more

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Can vincristine cause anemia?

Can vincristine cause anemia?

Anything is possible: But the manner in which we use vincristine in typical chemotherapy regimens is not myelosuppressive. You are far more likely to experience its neuropathic side effects, such as pain, parenthesis, foot drop, jaw pain, constipation, etc. Anemia, at least as a consequence of marrow hypofunction, would be highly unlikely, so much so that i would look for another cause. ...Read more

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Dr. Scott Keith
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Dr. Amanda Itzkoff
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