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My dad has MDS and getting his 5th cycle if Vidaza. Hb up by 3 to reach 12, and platelets now 160. But causing very low neutrophil. Solution?
Seek guidance from y:
Your dad's oncologist can address this issue and explain it. Please send us report of his neutrophil counts. If it is >500, that is considered safe. It is only worrysome if the total count is 100 or lower...then there is risk of Infection (Fever is the sign of infection).
His neutrophil counts will start recovering just like his Hb and platelets have. He may need Vidaza dose reduction. Neupogen ...Read more
Acute and delayed: Vidaza is well tolerated. But there can be mild nausea during chemo. Later on and for 2-4 weeks, blood counts go down causing anemia (low hemoglobin), and low WBC counts and low platelets. So patients need their blood counts checked frequently (once or twice weekly is common schedule) sometimes even daily counts required, if platelet counts drop below 30, 000. ...Read more
It is one treatment: This is one option of treatment for mds. It is not a difficult treatment, yet the disease is difficult to manage and control for too long. Good luck. ...Read more
What is the duration of severe neutropenia after Vidaza Treatment for MdS? Last vidaza Cycle ended 20 days ago. GSf given but no response yet.
4-6 weeks: Vidaza can cause prolonged neutropenia which can be followed by remission and recovery of neutrophils....but you need to give yourself 1 to 2 more weeks. On the other hand blood counts can remain very low if the MDS is resistant to Vidaza in which case there may not be any recovery of Neutrophils. A Bone marrow exam can help to differentiate these 2 possibilities and help in deciding the next step ...Read more
What are the most recent treatments for Intermediate risk MDS in elderly other than Vidaza & Revilmid? Any new treatment will be available soon?
Yes there are others: A good hematologist is the first requirement to treat MDS properly as there are several sub types of disease. Depending on which cell in the blood is impaired, a targeted drug can be selected to treat him. There are some drugs targeted for red cells (Anemia) and others for low WBC and low platelet counts. The 3rd approved drug to treat MDS is: Decitabine (Dacogen). ...Read more
Taking 2 types of intravenous antibiotics. Took vidaza 20 days ago. Can I take solgar advanced 40+ acidophilus? How many capsules per day?
MDS and Bacteria: Solgar Advanced 40+ Acidophilus contains these bacteria: L. acidophilus, L. rhamnosus GG, L. paracasei, B lactis and S. thermophilus. In general, it is recommended that neutropenic and infected patients avoid introducing more bacteria into their system. There is no credible evidence that these bacteria improve clinical outcomes and could introduce harm. ...Read more
Dad has MDS and on vidaza for since 4 months. Before treatment he needed 3 RBC units every 3 wks. Now 2 units in 5 wks. Is this partial response?
Yes: A response is considered as a rise in hemoglobin of at least 1.5 g/dl sustained for 8 wks AND a reduction in the number of RBC units by at least 4 units over the current 8 wks compared to the previous 8 wks. Doing some proportional adjustment:He required approximately 8 units the previous 8 wks and the estimated units for the current period is 3 units. Assumming his hemoglobin rose at least 1.5g/ ...Read more
10 days after last vidaza shot got fever that fluctuates between 37 & 38.5. Had a blood transfusion & fever started fluctuating between 38 and 40. Why?
Sure: Spirulina and chlorella are both health frauds that will not help or harm you. ...Read more
Recently diagnosed with cmml. Wbc 90 hb 7 palettes 94 no blasts. My current doctor started treatment with vidaza, is this correct therapy?
That is an: Excellent choice. This is a tough disease to treat. Stick with your doc and the plan. ...Read more
How many days does it take to go out febrile neutropenia for 70 yrs old man treated by Vidaza for High Risk MDS? His ANC is zero, 20 days post vidaza
Should be hospitalized: Febrile neutropenia is an emergency, hospitalization, isolation, broad spectrum antibiotics need to be given till recovery. Other treatments like G-CSF are given as per protocol for each institution, there may other problems causing delayed recovery from neutropenia, which would be assessed by treating team, good luck ...Read more
Will their be new treatments for intermediate risk MDS in 2016? Other than Vidaza and supportive care? I care abt newest treatment for 70 yr patient
Common drugs for MDS include:1.Azacitidine (Vidaza) 2.Cytarabine (Cytosar-U) 3.Daunorubicin (Cerubidine) 4. Decitabine (Dacogen) 5. Idarubicin (Idamycin) 6.Lenalidomide (Revlimid).Overall, 30 to 40% of patients may benefit.
Gene manipulation of own stem cell has cured, patients with severe advanced leukemia, is the future. Pts. Reported rapidly to iv infusion, was recently reported ...Read more
Maybe Infection.: The elevation of neutrophils coukl mean bacterial infection, as these cells are important in fighting this kind of infection. The high hemohlobin seems nonspecific, in abscence of other symptoms and signs. It could possibly mean a polycythemia, one of the porphorias, or a myeloproliferative disorder, which could explain the high neutrophils. It can also be from high altitude. See dr. For more. ...Read more
Usually an infection: The absolute neutrophil count is the product of the % neutrophils & total wbc. A high absolute neutrophil count is usually seen in many types of infections. Other causes are inflammatory conditions, stress, medications like steroids, lithium, injections like growth factors, cushing's disease and sometimes some forms of chronic leukemia or myeloproliferative disorders (blood disorder). ...Read more
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have helped to have the actual values for the test results. ...Read more
Infection: This is usually indicative of acute bacterial infection. ...Read more
Total number: This is the number of neutrophils in a standard volume of your blood. This count is lowish but probably not dangerous; your physician will want to keep an eye on it. If you're otherewise healthy I would not be concerned. ...Read more
Normal flucctuation: WBC counts fluctuate from one day to the other. Tell us why you are getting it checked in the first place? If you have some illness or symptoms, you need to describe them in some detail, so that we can relate your symptoms to your blood counts. Both of your counts are normal right now. ...Read more
Relative v.absolute?: The percentages can be misleading. One must really look at the absolute amounts of both. Depending on the circumstances, a true absolute neutrophilia may be caused by a list of conditions too long to list here. In most cases, the low monocyte count is due to the relative expansion of neutrophils (infections, smoking, trauma, autoimmune conditions, even some cancers). Your md should be able to help. ...Read more
It depends: A HGB less than 10.5 in a female or 11.5 in a male may be important. One cannot look just at lynphocyte and neutrophil percentages. It must be interpreted in the context of the total white blood cell count. ...Read more
Leukocytosis is...: ...an increase in the total number of WBCs due to any cause. From a practical standpoint, it is often sub-classified according to the component of white cells that contribute to an increase in the total number of WBCs. Context is important here--e.g. why did they test you? Read more at: http://emedicine. Medscape. Com/article/956278-overview ...Read more
TheTruthOnAbsolute: Percentages are relative numbers. You could have one billion neutrophils (elevated) but only 10% of total White Cells (low, %, based on normal ranges), but 10% of one billion is sky high. We are always looking at relative numbers and absolute numbers. Relative numbers like % can be manipulated in various ways, good and bad, but absolute numbers are the nitty-gritty. ...Read more
It is very: Likely. If the dip us related to the infection or it's treatment it is going to improve as things resolve. ...Read more
Wright's stain is a histologic stain that facilitates the differentiation of blood cell types. It is used primarily to stain peripheral blood smears and bone marrow aspirates which are examined under a light microscope. In cytogenetics it is used to stain chromosomes to facilitate diagnosis of syndromes and diseases.
It is named for james homer wright, who devised the stain. ...Read more