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Doctor insights on: Valproic Acid

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Valproic Acid (Overview)

Valproic acid was the first product followed by valproex sodium (depakote, far less toxic). A drug approved by fda to treat migraine and/or epilepsy, and often used in psychiatry in addition. Very potent and valuable agent in view of broad spectrum benefits, but side effects and pregnancy risks very real.


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What is valproic acid?

What is valproic acid?

Several things: Valproic acid, aka-depakote, aka-sodium divalproex is classified as an anticonvulsant or anti-seizure medication. It is used for epilepsy, bipolar disorder-as a mood stabilizer, and is also used for migraine headaches. ...Read more

Valproic Acid (Overview)

Valproic acid was the first product followed by valproex sodium (depakote, far less toxic). A drug approved by fda to treat migraine and/or epilepsy, and often used in psychiatry in addition. Very potent and valuable agent in view of broad spectrum benefits, but side effects and pregnancy risks very real.


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I am taking valproic acid and lamnet for seizures since last 3 yrs. Is there any long term side effect? Which meds should I avoid taking with these?

I am taking valproic acid and lamnet for seizures since last 3 yrs. Is there any long term side effect? Which meds should I avoid taking with these?

Probably not: Check with your neurologist and check what other meds you are taking. Stay healthy. I'm proud of you for being so careful. ...Read more

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Valproic acid at low doses causing greater mental adverse side effects, and greater physical side effects at higher dosages?

Valproic acid at low doses causing greater mental adverse side effects, and greater physical side effects at higher dosages?

Dose related: Both mental and physical side effects with valproic acid are usually dose related (higher the higher the dose). However, you might notice that the effectiveness (reduction in mental symptoms) is also dose related. What you are thinking of as adverse mental side effects might be untreated psychiatric symptoms. Part of what makes psychiatry interesting! :-). ...Read more

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How long does it take for valproic acid to get in your system?

How long does it take for valproic acid to get in your system?

Medication effect: This is common question, most psych meds get quickly into your 'system' or blood and brain, but the effects are usually delayed often several weeks. Side effects occur when blood levels peak in a few days, but benefits can take weeks. So be patient. ...Read more

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What is valproic acid?

Several things: Valproic acid, aka-depakote, aka-sodium divalproex is classified as an anticonvulsant or anti-seizure medication. It is used for epilepsy, bipolar disorder-as a mood stabilizer, and is also used for migraine headaches. ...Read more

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How is valproic acid excreted?

In the urine: Valproic acid is metabolized in the liver by a number of enzymes, but is excreted in the urine. Less than 3 % is excreted unchanged as valproic acid. ...Read more

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How can you check a valproic acid trough?

Timing: A valproic acid trough level, which is what should be measured, needs to be drawn ten to twelve hours after the last dose. Btw-the therapeutic range for levels is 50-100 for seizures, but it is 75-125 for mood stabilization. Other labs which should be drawn with the level are a CBC (blood count), and ast/alt (liver enzymes). ...Read more

Dr. Daniel Saurborn
40 doctors shared insights

Depakene (Definition)

Depakene is an anti-migrane agent which is a kind of ...Read more