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Doctor insights on: Valproic Acid

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Valproic Acid (Overview)

Valproic acid was the first product followed by valproex sodium (depakote, far less toxic). A drug approved by fda to treat migraine and/or epilepsy, and often used in psychiatry in addition. Very potent and valuable agent in view of broad spectrum benefits, but side effects and pregnancy risks very real.


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What is valproic acid?

What is valproic acid?

Several things: Valproic acid, aka-depakote, aka-sodium divalproex is classified as an anticonvulsant or anti-seizure medication. It is used for epilepsy, bipolar disorder-as a mood stabilizer, and is also used for migraine headaches. ...Read more

Valproic Acid (Overview)

Valproic acid was the first product followed by valproex sodium (depakote, far less toxic). A drug approved by fda to treat migraine and/or epilepsy, and often used in psychiatry in addition. Very potent and valuable agent in view of broad spectrum benefits, but side effects and pregnancy risks very real.


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I am taking valproic acid and lamnet for seizures since last 3 yrs. Is there any long term side effect? Which meds should I avoid taking with these?

I am taking valproic acid and lamnet for seizures since last 3 yrs. Is there any long term side effect? Which meds should I avoid taking with these?

Probably not: Check with your neurologist and check what other meds you are taking. Stay healthy. I'm proud of you for being so careful. ...Read more

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Valproic acid at low doses causing greater mental adverse side effects, and greater physical side effects at higher dosages?

Valproic acid at low doses causing greater mental adverse side effects, and greater physical side effects at higher dosages?

Dose related: Both mental and physical side effects with valproic acid are usually dose related (higher the higher the dose). However, you might notice that the effectiveness (reduction in mental symptoms) is also dose related. What you are thinking of as adverse mental side effects might be untreated psychiatric symptoms. Part of what makes psychiatry interesting! :-). ...Read more

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How long does it take for valproic acid to get in your system?

How long does it take for valproic acid to get in your system?

Medication effect: This is common question, most psych meds get quickly into your 'system' or blood and brain, but the effects are usually delayed often several weeks. Side effects occur when blood levels peak in a few days, but benefits can take weeks. So be patient. ...Read more

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What is valproic acid?

Several things: Valproic acid, aka-depakote, aka-sodium divalproex is classified as an anticonvulsant or anti-seizure medication. It is used for epilepsy, bipolar disorder-as a mood stabilizer, and is also used for migraine headaches. ...Read more

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How is valproic acid excreted?

In the urine: Valproic acid is metabolized in the liver by a number of enzymes, but is excreted in the urine. Less than 3 % is excreted unchanged as valproic acid. ...Read more

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How can you check a valproic acid trough?

Timing: A valproic acid trough level, which is what should be measured, needs to be drawn ten to twelve hours after the last dose. Btw-the therapeutic range for levels is 50-100 for seizures, but it is 75-125 for mood stabilization. Other labs which should be drawn with the level are a CBC (blood count), and ast/alt (liver enzymes). ...Read more

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What is the definition or description of: valproic acid?

Depakote: Valproic acid was the first product followed by valproex sodium (depakote, far less toxic). A drug approved by fda to treat migraine and/or epilepsy, and often used in psychiatry in addition. Very potent and valuable agent in view of broad spectrum benefits, but side effects and pregnancy risks very real. ...Read more

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What are the differences between valproic acid and lithium?

What are the differences between valproic acid and lithium?

Considerable: Although Depakote and lithium are both prescribed and are effective for the treatment of bipolar d/o, they do differ.Depakote is actually an anticonvulsant medication prescribed for seizures, while lithium is not. The latter is basically a mineral and considered a mood stabilizing medication. Lithium is metabolized through the kidneys, while Depakote is through the liver. ...Read more

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How long does it take for valproic acid to get in your system?

Medication effect: This is common question, most psych meds get quickly into your 'system' or blood and brain, but the effects are usually delayed often several weeks. Side effects occur when blood levels peak in a few days, but benefits can take weeks. So be patient. ...Read more

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Can you take nyquil with valproic acid medicine?

Yes: Shouldn't cause a problem but tell your doc you are doing it. ...Read more

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Is it okay to take orlistat if you are taking valproic acid?

Categorically NO: If the valproate is for seizure control, i would definitely not recommend you take orlistat. Valproate is a prescription and should be given for a definite purpose. Orlistat is going to move things throug the bowel faster, inhibit fat absorption and can case mal-absorption of fat soluable vitamins in the diet. You end up pooping oil. If you do this, you should be under strict care of your doc. ...Read more

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Differences between valproic acid & Sodium valproate?

Not important: There is a technical chemical distinction between them, but no important difference for patients. ...Read more

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What is a common reaction to Depakote / valproic acid?

What is a common reaction to Depakote / valproic acid?

Side effects?: Valproic acid is mainly used for the treatment of seizure disorders , bipolar depression or prevention of migraine headaches most important side effects are weight gain, occasional hair loss and ovarian cysts . It rarely causes fetal abnormalities (related to the development of the neural tube)in pregnancy. ...Read more

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What is the definition or description of: Depakene (valproic acid) allergy?

What is the definition or description of: Depakene (valproic acid) allergy?

STOP!!: What is the point in asking so many unhelpful questions and crowding the reply section when IF you really want to know the answer you can get it on the internet This service is for people who genuinely want reasonable answers not available elsewhere! ...Read more

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Should valproic acid 1500 mg and sodium valproate 1500 mg be taken together?

Depakote: Not sure why u would be taking the same medication twice ?. Also, make sure your blood level is therapeutic. ...Read more

Dr. Julie Abbott
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Depakene (Definition)

Depakene is an anti-migrane agent which is a kind of ...Read more