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Doctor insights on: Valdoxan

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What is Agomelatine and why not approve of fda?

What is Agomelatine and why not approve of fda?

Agomelatine: Is a Melatonergic antidepressant, removed in Oct. 2011 due to effect on liver & kidneys. ...Read more

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Is it likely that I will gain weight if I start a dose of 25mg Valdoxan, thank you?

Is it likely that I will gain weight if I start a dose of 25mg Valdoxan, thank you?

Uncertain: There are not enough studies upon which to base a concise response to our question. In various studies, the drop-out rate for all side effects was less than with several other antidepressants. If you are concerned, discuss with your MD and set a threshold, say 7 pounds, that will prompt a discussion and review of the treatment choices. ...Read more

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Is it ok to take half of a 25mg valdoxan tablet? 25mg too much for me and less then a half tablet still healp me sleep.

Is it ok to take half of a 25mg valdoxan tablet? 25mg too much for me and less then a half tablet still healp me sleep.

INSOMNIA EVAL: You need full EXAM AND labs. CBC/CMP/B12/FOLATE /TFTS/VITD/CRP//SED RATE//IRON STUDIES/LYME TITERS. Start a. Gluten free diet Wholeapproach. Com gutbliss. Com. And high potency vitamins. Rejuvenation-science. Com Then review results if no firm diagnosis is made, a sleep study may be necessary many subtle sleep disorders cause Fatigue. Recheck full thyroid panel and thyroid antibodies. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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I am about to change from Effexor (venlafaxine) to valdoxan. Do I really need 3 weeks to come off Effexor (venlafaxine)? I would rather just take a week off and get it done.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
I am about to change from Effexor (venlafaxine) to valdoxan. Do I really need 3 weeks to come off Effexor (venlafaxine)? I would rather just take a week off and get it done.

Effexor (venlafaxine): Withdrawal from Effexor (venlafaxine) is common if dose reduction is rapid. You did not mention what dose Effexor (venlafaxine) you are taking & how long you have been on it. I recommend for my patients to reduce the dose by 1/3 every week, then discontinue. Pleasediscusswith yourdoctor. ...Read more

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Under what circumstances is agomelatine prescribed rather than conventional ssri antidepressant drugs?

Only if others fail: I had to research this question as agomelatine is not approved in the United States. It appears that the data for this medicine is all over the place. There is some question how effective it truly is. It appears it is mainly prescribed in individuals who have failed or cannot take other anti-depressants. It does work differently from ssris. ...Read more

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On valdoxan for 5 years, last 2 years only taking half a pill 12.5mg still makes me sleepy and tired all day. Can I stop and use 5-htp?

On valdoxan for 5 years, last 2 years only taking half a pill 12.5mg still makes me sleepy and tired all day. Can I stop and use 5-htp?

Complex question: Valdoxan (agomelatine) is typically used as an antidepressant medication.
5-HTP is a serotonin precursor.
I notice you also take lamotrigine. Have you considered the possibility that the lamotrigine causes tiredness?
5-HTP, in my view, is not robustly effective as an antidepressant. Bupropion (Wellbutrin) is unlikely to cause sedation.
I would suggest talking w your doctor about alternatives. ...Read more

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Can you mix valdoxan, pristiq (desvenlafaxine) and seroquel?

Can you mix valdoxan, pristiq (desvenlafaxine) and seroquel?

A /W Dr. Zimmerman: Am unable to check Valdoxan (agomelatine). Per the Drugs. Com drug interaction checker using Seroquel (quetiapine) & Pristiq (desvenlafaxine) together may ^
potential fo r dizziness, drowsiness, confusion, & problems with concentration. However, they can be used together. ...Read more

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Want to try garcinia slim life but I am on valdoxan & seroquel (quetiapine). Is there any interactions?

Want to try garcinia slim life but I am on valdoxan & seroquel (quetiapine). Is there any interactions?

Don't waste your $: There may be interactions with psych meds that modulate serotonin e.g. Prozac, Zoloft, (sertraline) etc. But evidence is sparse & comes from mouse studies. But I'd avoid it because it's mostly WORTHLESS. A careful review of favorable medical reports of GC found that THEY were mostly worthless. Think critically. Be skeptical. Arm yourself with REAL KNOWLEDGE. Don't be an easy mark for the snake-oil salesmen. ...Read more

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I'm on Valdoxan 50mg, and my doctor just prescribed me with Luvox (fluvoxamine) 50mg. I later read that the two drugs are contraindicated. Should I still take both?

I'm on Valdoxan 50mg, and my doctor just prescribed me with Luvox (fluvoxamine) 50mg. I later read that the two drugs are contraindicated. Should I still take both?

I wouldn't: Certain enzymes--CYP1A2, CYP2C9, CYP2C19--in Valdoxan/agomelatine are inhibited by the SSRI antidepressant fluvoxamine/Luvox. This leads to higher levels of agomelatine in your body when the drugs are taken together. You need to get a second opinion on what is best treatment for you, or at least candidly ask your doctor why both of these were prescribed together. Best wishes:) ...Read more

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Can valdoxan couse weight gain or water retention?

Can valdoxan couse weight gain or water retention?

Most likely not: Please check out the side effects on the following link; http://en. M.Wikipedia. Org/wiki/agomelatine. ...Read more

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How is valdoxan different from zolof and is it a ssri like zolof. Also had been hearing good things about this med. Would it help 4 bipolar disorder

How is valdoxan different from zolof and is it a ssri like zolof. Also had been hearing good things about this med. Would it help 4 bipolar disorder

Not an SSRI: Valdoxan is a melatonin agonist rather than an ssri antidepressant. Most antidepressants, with the possible exception of bupropion, may make bipolar disorder worse - either by causing a switch into mania or hypomania, or increasing the frequency, over time, of depressive cycles. Although it is not a traditional antidepressant, there is caution about using it in bipolar disorder. ...Read more

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What is your openion of treating recurrent depression with valdoxan 25 mg (agomelatine) now compleat cure for one year. How long duration of treatment

What is your openion of treating recurrent depression with valdoxan 25 mg (agomelatine) now compleat cure for one year. How long duration of treatment

Agomelatine: Glad to hear you've experienced some results. Agomelatine isn't yet marketed in the us, and clinical studies are ongoing. It's a melatonin agonist and also antagonizes certain serotonin receptors; yet it hasn't been associated with sexual side effects as others have. So far there are mixed reviews of it though, questioning hepatotoxicity & other issues. We'll have to wait for study outcome. ...Read more

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Doctor has changed medication from Pristiq (desvenlafaxine) and Olanzapine to Valdoxan. Just wondering what to expect please and why a change?

Doctor has changed medication from Pristiq (desvenlafaxine) and Olanzapine to Valdoxan. Just wondering what to expect please and why a change?

Good question: Your question is important. It needs to be addressed to the prescriber. That is not happening, and it suggests that there may be a problem in your relationship. It is the kind of information and the kind of communication that is of central importance with a prescriber. Perhaps something is wrong in that relationship. ...Read more

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I have low libido for a long time. My doctor prescribed me Valdoxan. Can this help or make things worse? I I'm afraid the side effects of antidepressants

Tough question!: It's the chicken and the egg story. Which came first? Low Libido or depression or vice versa. Low libido can be a symptom of depression. Did you have a good physical and workup before you were diagnosed with depression? Normal thyroid functions? There are nonmedical treatments for depression, exercise and good therapy. Also alcohol is a no-no for both libido and mood control. Talk to your doc. ...Read more

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I was switched from 150mg Effexor (venlafaxine) to 50mg valdoxan directly 4 weeks ago. I now notice irritability and anger. Is this withdrawal or depression?

I was switched from 150mg Effexor (venlafaxine) to 50mg valdoxan directly 4 weeks ago. I now notice irritability and anger. Is this withdrawal or depression?

Hard to say but...: Effexor (venlafaxine) is notorious for causing bad withdrawal symptoms of which irritability could be one. You might suspect depression if other symptoms of depression are present such as loss of interest in pleausurable activities, decreased appetite and energy, poor sleep, guilty feelings, poor concentration. Definitely talk with your health care provider. ...Read more

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