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Doctor insights on: Use Of Aromatase Inhibitor Without Ovarian Suppression In Pre Menopausal Women

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Janet Greenhut
1,730 Doctors shared insights

Menopause (Definition)

The absence of menstrual periods for 12 months. During menopause, the ovaries stop producing estrogen and progesterone. After the complete transition into menopause, women can no longer get pregnant. The average age for menopause is 51 years old. Symptoms include dry vaginal tissue, irregular periods, hot flashes, mood ...Read more


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Xeloda (capecitabine). Can someone go off Chemo and on an Aromatase Inhibitor after taking Xeloda (capecitabine). I am not menopausal yet and have BC mets to lymph and? Liver?

Xeloda (capecitabine). Can someone go off Chemo and on an Aromatase Inhibitor after taking Xeloda (capecitabine). I am not menopausal yet and have BC mets to lymph and? Liver?

Yes and No: You have to give us details of your medical history such as when was your breast cancer first diagnosed? When did it becomemetastatic? What all drugs have been used to treat your breast cancer so far. Have you been treated with Tamoxifen before? Did Tamoxifen help control your breast Cancer anytime or it did not? AI's are typically not used in Premenopausal patients because you ovaries are active ...Read more

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What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?

What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?

Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more

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Is tamoxifen the same as aromatase inhibitor?

Is tamoxifen the same as aromatase inhibitor?

No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more

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Is it healthy to take an chrysin surge aromatase inhibitor as a teen?

Is it healthy to take an chrysin surge aromatase inhibitor as a teen?

No it is not.: Even though it is an over the counter supplement, it is not recommended by any reputable manufacturer to be taken before you are 18. If you are asking about it as a way to increase your testosterone levels, remember if it was successful it would prematurely lead to your bones fusing and stunt your growth/height! ...Read more

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Can aromatase inhibitor help me get rid of gynecomastia?

Can aromatase inhibitor help me get rid of gynecomastia?

Possibly but...: Much will depend on your specific situation and on your own physician's thoughts after physical examination. I have found that gynecomastia, if persistent, is often best treated with partial excision of the prominent glandular tissue as well as liposuction surgery of the peripheral chest area. ...Read more

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How’s an aromatase inhibitor used for breast cancer?

How’s an aromatase inhibitor used for breast cancer?

Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read more

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Is it safe to take HCG (for wt loss) when on an aromatase inhibitor, ihave taken it previous but was not on the arimadex at the time thanks?

Is it safe to take HCG (for wt loss) when on an aromatase inhibitor, ihave taken it previous but was not on the arimadex at the time thanks?

Not defined: I assume the aromatase inhibitors are being used to manage potential or existing metastatic breast cancer. HCG is a hormone developing during pregnancy which does have some beneficial effect on cancer, at least with regard to the n-terminal repeat of the molecule. How it effects breast cancer has not been reported and when used for diet many patients overuse the product and become anorexic. ...Read more

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Will an aromatase inhibitor help me get rid of my male gynecomastia?

Will an aromatase inhibitor help me get rid of my male gynecomastia?

Be careful.: Make sure gynecomastia is the correct diagnosis. Breast cancer in male patients is very rare, but can be potentially life threatening. Using medications such as an aromatase inhibitor for breast swelling before eliminating the diagnosis of breast cancer can be potentially serious. Check with your doctor for details. ...Read more

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Is a potent aromatase inhibitor (letrozole) effevtive in delaying epiphyseal fusion and thus making me grow taller? I am 18 years old

Is a potent aromatase inhibitor (letrozole) effevtive in delaying epiphyseal fusion and thus making me grow taller? I am 18 years old

I doubt it: Letrozole is not used for this purpose as far as I know. Nothing works well to increase your height! . So do not waste your money and time...Just eat healthy and nature will take care of the rest of the health issues and your body. ...Read more

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Is aromatase inhibitor treatment likely to normalize the levels of elevated estradiol, 5-HIAA, histamine and lipid status? Thank you.

Is aromatase inhibitor treatment likely to normalize the levels of elevated estradiol, 5-HIAA, histamine and lipid status? Thank you.

What aroma is that??: Yes, and it cures baldness and will get rid of an annoying girlfriend. Well, actually, it just inhibits the conversion of testost to estrogens in your body cells (it works overtime in fat cells).Its relationship to 5-HIAA is sketchy at best (far as I know)and on blood lipids very complex and probably opposite what you think. No easy answers here, except: you gotta histamine problem? Take an antihistamine! ...Read more

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If a natural weightlifter took anti cancer medication (aromatase inhibitor), shouldn't his testosterone level increase dramatically?

Increase somewhat: Aromatase inhibitors inhibit the effect of estrogen on the pituitary gland as well as elsewhere. As a result they can increase pituitary hormones that stimulate testosterone production modestly, not usually dramatically. By the way, these medications are banned by most major sports ...Read more

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Low testosterone, low estradiol, high estrone, weight good, taking 200mg testosterone a day at cheek & gum, using a aromatase inhibitor, why low t?

Low testosterone, low estradiol, high estrone, weight good, taking 200mg testosterone a day at cheek & gum, using a aromatase inhibitor, why low t?

Difficult to say: Some guys just do not make enough and need supplementation. You might just fall in that category. It sounds like you have had a work up and you do not have a tumor or anything else to account for your low testosterone. ...Read more

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Can aromatase inhibitors be used to increase final height in puberty in boys?

Can aromatase inhibitors be used to increase final height in puberty in boys?

May be effective: For boys with short stature, and no other known cause, aromatase inhibitors have been used. It is still considered experimental, and it is not clear that it will increase adult height. Much depends on the specific condition. As with anything that may increase testosterone, there are side effects. You should only do this under the care/supervision of a pediatric endocrinologist. ...Read more

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Any over-the-counter aromatase inhibitors?

No: There are no over the counter aromatase inhibitors. They are only available by prescription. ...Read more

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Is there a homeopathic alternative for aromatase inhibitors?

Is there a homeopathic alternative for aromatase inhibitors?

No: If you have been prescribed aromatase inhibitors, presumably you have hormone sensitive breast cancer. Do not substitute the homeopathic placebo for your medications. The data on breast cancer treatment is solid for aromatase inhibitors and using a homeopathic placebo might prove lethal. ...Read more

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Does fda approved aromatase inhibitors in pediatrics?

Does fda approved aromatase inhibitors in pediatrics?

Probably never will: Many of the drugs we use in pediatric oncology are never approved by the fda for treatment of a particular pediatric cancer. Once it gains fda approval for an adult disease indication, we then can study it in clinical trials, and if warranted, use it. ...Read more

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