Doctor insights on:
Use Of Aromatase Inhibitor Without Ovarian Suppression In Pre Menopausal Women
Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?
Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read moreSee 2 more doctor answers
Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?
Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read moreSee 2 more doctor answers
Au Contraire!: Chemistry is a foreign language too, worse when used in drugs. This cmpd has an additional -oh group on the steroid rings, so cleave it an you get Estradiol - pure estrogen. Contraindicated in people with er + tumors, i.E makes tumors grow. It is proposed as an alternative to prempro (conjugated estrogens and medroxyprogesterone) for thos with severe hot flashes, and not at high risk for breast cancer. ...Read moreSee 1 more doctor answer
Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?
Tamoxifen: We don't give tamoxifen in combination with hormone replacement in the us. Occassionally use vaginal very low dose estrogen cream for vag dryness and tell pts to use a little as they can to relieve symptoms. Blocking hormones and giving them at same time does not make much sense. ...Read more
Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?
Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read moreSee 1 more doctor answer
What is the risk associated with suppressing fsh/lh when using Clomid (clomiphene) to increase testosterone in men?
Clomid (clomiphene) increases LH: The use of Clomiphene citrate increases testosterone by increasing the lh levels and stimulating testosterone production by the testes. It also increases fsh ( thus it's use as a fertility drug for women) the only theoretic risk would be secondary to overstimulation of the testes, which in theory might increase the risk for testicular germ cell tumors, although i know of no diagnosed cases of this. ...Read moreSee 1 more doctor answer
What arethe possible side effects of using letrozole to attempt to treat endometriosis in a pre-menopausal woman without added birth control/hormones?
Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?
Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more
What is the risk associated with suppressing fsh/lh when using hCG to increase testosterone in men?
Minimal: Let's put it this way: using any type of t to replace/fix hypogonadism/andropause will also suppress fsh/lh. But more importantly, taking t will shut down testicular function from lack of fsh/lh. Using HCG to stimulate the testes to produce more t & sperm will result in negative feedback @ pituitary, thus suppress lh/fsh. But at least your testes are functioning fully. It's off-label but it works. ...Read moreSee 1 more doctor answer
With previous p.E from tamoxifen, what's the safest anti estrogen to use after an anabolic steroid cycle? Will be using arimidex (anastrozole) throughout for gyno
Possible: I do not now about the efficacy of anastrazole (arimidex) after anabolic steroid cycle ( I am not sure what exactly you are referring to). However, both drugs and others are used for breast cancer treatment and prevention ( for anastrazole, prevention study is ongoing). Unlike tamoxifen, the risk of blood clot with anastrazole is minimal. However, the risk of osteopenia and osteoporosis is higher. ...Read more
YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read moreSee 3 more doctor answers
Yes: Migraine usually first occurs in teens when their estrogen levels are spiking. Many women tend to get more migraines at certain times of their cycle. Menopause may offer relief as estrogen levels go down, but taking estrogen may make migraine worse. However, if a woman has not had migraine before, taking estrogen in menopause is unlike to cause it. Other causes for headaches should be considered. ...Read more
Dep.: Hormonal changes in susceptible women can affect moods. ...Read more
Is HRT a necessary preventive measure for every menopausal woman or only those that are at risk of osteoporosis? I'm aware of hrt's potential risks
Many benefits: Hrt is known to reduce the risk of stroke, heart attack, colon cancer, alzheimers' disease, and osteporosis - when started at the time of menopause. Almost all studies show that women who take HRT are healthier and live longer than women who do not take hrt. There are few contraindications to hrt. Additional benefits include decreased hot flushes, decreased insomnia, and decreased vaginal dryness. ...Read moreSee 1 more doctor answer