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Doctor insights on: Use Of Aromatase Inhibitor Without Ovarian Suppression In Pre Menopausal Women

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Dr. Janet Greenhut
1,739 doctors shared insights

Menopause (Definition)

The absence of menstrual periods for 12 months. During menopause, the ovaries stop producing estrogen and progesterone. After the complete transition into menopause, women can no longer get pregnant. The average age for menopause is 51 years old. Symptoms include dry vaginal tissue, irregular periods, hot flashes, mood ...Read more


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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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Can using estriol protect against future breast cancer in a peri or post menopausal woman?

Can using estriol protect against future breast cancer in a peri or post menopausal woman?

Au Contraire!: Chemistry is a foreign language too, worse when used in drugs. This cmpd has an additional -oh group on the steroid rings, so cleave it an you get Estradiol - pure estrogen. Contraindicated in people with er + tumors, i.E makes tumors grow. It is proposed as an alternative to prempro (conjugated estrogens and medroxyprogesterone) for thos with severe hot flashes, and not at high risk for breast cancer. ...Read more

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Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?

Tamoxifen: We don't give tamoxifen in combination with hormone replacement in the us. Occassionally use vaginal very low dose estrogen cream for vag dryness and tell pts to use a little as they can to relieve symptoms. Blocking hormones and giving them at same time does not make much sense. ...Read more

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Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read more

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What is the risk associated with suppressing fsh/lh when using Clomid (clomiphene) to increase testosterone in men?

What is the risk associated with  suppressing fsh/lh when using Clomid (clomiphene) to increase testosterone in men?

Clomid (clomiphene) increases LH: The use of Clomiphene citrate increases testosterone by increasing the lh levels and stimulating testosterone production by the testes. It also increases fsh ( thus it's use as a fertility drug for women) the only theoretic risk would be secondary to overstimulation of the testes, which in theory might increase the risk for testicular germ cell tumors, although i know of no diagnosed cases of this. ...Read more

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What arethe possible side effects of using letrozole to attempt to treat endometriosis in a pre-menopausal woman without added birth control/hormones?

What arethe possible side effects of using letrozole to attempt to treat endometriosis in a pre-menopausal woman without added birth control/hormones?

Endometriosis: Without question and without delay you must make an appointment to see a Gynecologist. If possible prepare a brief list of the medical issues you have had recently. That will help the doctor take good care of you. Please keep me posted. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Should men receiving zoladex (goserelin) for prostate cancer be on some form of HRT as well?

Should men receiving zoladex (goserelin) for prostate cancer be on some form of HRT as well?

Hormones: Prostate cancer growth is slowed down by meds like that to reduce testosterone. You wouldn't want to take testosterone, it makes the cancer grow ! good multi vitamin and calcium are good ideas when on testosterone suppression for pca. ...Read more

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What is the risk associated with suppressing fsh/lh when using hCG to increase testosterone in men?

What is the risk associated with  suppressing fsh/lh when using hCG to increase testosterone in men?

Minimal: Let's put it this way: using any type of t to replace/fix hypogonadism/andropause will also suppress fsh/lh. But more importantly, taking t will shut down testicular function from lack of fsh/lh. Using HCG to stimulate the testes to produce more t & sperm will result in negative feedback @ pituitary, thus suppress lh/fsh. But at least your testes are functioning fully. It's off-label but it works. ...Read more

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With previous p.E from tamoxifen, what's the safest anti estrogen to use after an anabolic steroid cycle? Will be using arimidex (anastrozole) throughout for gyno

With previous p.E from tamoxifen, what's the safest anti estrogen to use after an anabolic steroid cycle? Will be using arimidex (anastrozole) throughout for gyno

Possible: I do not now about the efficacy of anastrazole (arimidex) after anabolic steroid cycle ( I am not sure what exactly you are referring to). However, both drugs and others are used for breast cancer treatment and prevention ( for anastrazole, prevention study is ongoing). Unlike tamoxifen, the risk of blood clot with anastrazole is minimal. However, the risk of osteopenia and osteoporosis is higher. ...Read more

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Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read more

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Is there an increased risk of migraine for women who take estrogen for menopausal symptoms?

Is there an increased risk of migraine for women who take estrogen for menopausal symptoms?

Yes: Migraine usually first occurs in teens when their estrogen levels are spiking. Many women tend to get more migraines at certain times of their cycle. Menopause may offer relief as estrogen levels go down, but taking estrogen may make migraine worse. However, if a woman has not had migraine before, taking estrogen in menopause is unlike to cause it. Other causes for headaches should be considered. ...Read more

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Is HRT a necessary preventive measure for every menopausal woman or only those that are at risk of osteoporosis? I'm aware of hrt's potential risks

Is HRT a necessary preventive measure for every menopausal woman or only those that are at risk of osteoporosis? I'm aware of hrt's potential risks

Many benefits: Hrt is known to reduce the risk of stroke, heart attack, colon cancer, alzheimers' disease, and osteporosis - when started at the time of menopause. Almost all studies show that women who take HRT are healthier and live longer than women who do not take hrt. There are few contraindications to hrt. Additional benefits include decreased hot flushes, decreased insomnia, and decreased vaginal dryness. ...Read more

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Estrogen in contraception pills or menopausal hormone therapy have same effect?

Estrogen in contraception pills or menopausal hormone therapy have same effect?

Mostly yes: Pharmacologically yes, although the amount of estrogen in hrt is usually lower than in ocp; therefore symptomatically it might be different. Some hrt also contains different estrogen types, for example conjugated equine estrogens, but the basic effect is still similar. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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With zero estrogen after surgical menopause, and no HRT how can I protect myself against the potenial side effects such as altzeimers, lung cancer et?

Exercise: The best defense against chronic diseases (including cancer) is living a healthful lifestyle (i.e. Eating an anti-inflammatory diet, exercise, stress reduction, don't smoke, avoid toxins and carcinogens.). ...Read more

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