Doctor insights on:
Use Of Aromatase Inhibitor Without Ovarian Suppression In Pre Menopausal Women
Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?
Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read moreSee 1 more doctor answer
Menopause is defined as the absence of menstrual periods for 12 months. During menopause, the ovaries stop producing estrogen and progesterone. After the complete transition into menopause, women can no longer get pregnant. The average age for menopause is 51 years old. Symptoms include dry vaginal tissue, irregular periods, hot flashes, mood ...Read more
Xeloda (capecitabine). Can someone go off Chemo and on an Aromatase Inhibitor after taking Xeloda (capecitabine). I am not menopausal yet and have BC mets to lymph and ? Liver?
Yes and No: You have to give us details of your medical history such as when was your breast cancer first diagnosed? When did it becomemetastatic? What all drugs have been used to treat your breast cancer so far.Have you been treated with Tamoxifen before? Did Tamoxifen help control your breast Cancer anytime or it did not? AI's are typically not used in Premenopausal patients because you ovaries are active ...Read more
What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?
Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more
No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read moreSee 1 more doctor answer
No it is not.: Even though it is an over the counter supplement, it is not recommended by any reputable manufacturer to be taken before you are 18. If you are asking about it as a way to increase your testosterone levels, remember if it was successful it would prematurely lead to your bones fusing and stunt your growth/height! ...Read more
Possibly but...: Much will depend on your specific situation and on your own physician's thoughts after physical examination. I have found that gynecomastia, if persistent, is often best treated with partial excision of the prominent glandular tissue as well as liposuction surgery of the peripheral chest area. ...Read moreSee 2 more doctor answers
Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read moreSee 1 more doctor answer
Is it safe to take HCG( for wt loss) when on an aromatase inhibitor ,ihave taken it previous but was not on the arimadex at the time thanks?
Not defined: I assume the aromatase inhibitors are being used to manage potential or existing metastatic breast cancer. HCG is a hormone developing during pregnancy which does have some beneficial effect on cancer, at least with regard to the n-terminal repeat of the molecule. How it effects breast cancer has not been reported and when used for diet many patients overuse the product and become anorexic . ...Read more
Be careful.: Make sure gynecomastia is the correct diagnosis. Breast cancer in male patients is very rare, but can be potentially life threatening. Using medications such as an aromatase inhibitor for breast swelling before eliminating the diagnosis of breast cancer can be potentially serious. Check with your doctor for details. ...Read moreSee 2 more doctor answers