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Doctor insights on: Urine Kappa Lambda Light Chains

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below. http://www.aafp.org/afp/2005/0101/p105.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356447/ Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

Urine (Definition)

Urine is the product of the kidneys, which is produced to eliminate the waste products of metabolism, manage body fluid balance, &maintain acid-base balance. The blood is first filtered by the kidneys, and the composition of the resulting fluid is then altered depending on the body's needs. It is composed of mostly water, and breakdown products from blood cells impart ...Read more


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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more

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Dealing with Blood in Urine (Checklist)

Rule out infection as a cause with a urinalysis or culture
once
Ask your doctor to review your medications to identify cause
once
Rule out kidney stones with your doctor
once
If male, schedule a prostate exam
once
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Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Immunoglobulin free lt chains blood results :  kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Labs: Cannot possibly interpret lab results in the absence of a medical history and exam. If you have had these tests ordered by a doctor, discuss results with them. ...Read more

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Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550 ? What's mean

Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550 ? What's mean

Unclear data: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the data you provided does not seem to add up. What did serum and urine protein electrophoresis show? You wish to talk to the pathologist of the lab that did the tests. ...Read more

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Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H)  24 hour urine  What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more

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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do i calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl.  What does it mean, how do i calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read more

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Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm.  What can be suspected? Anemia, worsening ckd, improves with na co3

K+L chains in ua: hello, the fact that you are having this checked in your urine means that some person is already onto the fact that you may have MGUS or multiple myeloma. The worsening anemia and kidney deterioration is more indicative of myeloma. BUT you need the whole urine and blood protein electrophoresis to look at before making the diagnosis. You shd request referral to a Heme-Onc specialist to decide.thx ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa,lambda ratio is 1.19. Is it myeloma What is test 4

Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa,lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done.  Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range.  What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains,s, and kappa/lambda ratio,s is 1.66 What does this mean?

I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains,s, and kappa/lambda ratio,s is 1.66 What does this mean?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Why were these tests done? Do you have any symptoms? Kappa/lambda ratio is generally a useless test. IgA of 549, per se is not a problem. Sed rate is in the normal range. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma.org/pdfs/U-Freelite-Eng2011_g2web.pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;; Normal levels of serum free light chains are*: • Kappa: 3.3–19.4 mg/L* • Lambda: 5.71–26.3 mg/L* • Kappa/lambda ratio: 0.26–1.65** *Note: The units here are mg/L; different laboratories use different units. It is important to double-check the units used when comparing numbers in lab values. **Further Note: In patients with renal impairment, it is recommended to interpret the results of the Kappa/Lambda ratio with a modified reference range of 0.37–3.1. ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Can you get all amyloidosis if you have kappa rather than lambda light chains?  I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below. http://www.aafp.org/afp/2005/0101/p105.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356447/ Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

0.26-1.65 K/L ratio: Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of about 0.26 to 1.65. Increased kappa free light chains and a higher kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal kappa chains. Increased lambda free light chains and a lower kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal lambda chains. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist  says my kappa lambda ratio is  seriously skewed. Kappa light chains @580  paraproteins 30. Does this imply  a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

What is the significance of having low serum levels of kappa and lambda free light chains?  I had high ch50 and normal C3 and c4.

The: Concern would be low ch50 and low c3 ; c4, like in lupus. Elevations in kappa or lambda would be of concern for myeloma, not to worry about these levels. ...Read more

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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more