Top
10
Doctor insights on: Urine Immunofixation

Share
1

1
Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

MGUS: Sounds like monoclonal gammopathy of undetermined significance (mgus). Cannot say much more without knowing other clinical features -- eg lymphadenopathy, cbc, "crab" symptoms (hypercalcemia, renal insufficiency, anemia, bone disease). ...Read more

Urine (Definition)

Urine is the product of the kidneys, which is produced to eliminate the waste products of metabolism, manage body fluid balance, &maintain acid-base balance. The blood is first filtered by the kidneys, and the composition of the resulting fluid is then altered depending on the body's needs. It is composed of mostly water, and breakdown products from blood cells impart ...Read more


2

2
Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

MGUS: Sounds like monoclonal gammopathy of undetermined significance (mgus). Cannot say much more without knowing other clinical features -- eg lymphadenopathy, cbc, "crab" symptoms (hypercalcemia, renal insufficiency, anemia, bone disease). ...Read more

3

3
Dealing with Blood in Urine (Checklist)

Rule out infection as a cause with a urinalysis or culture
once
Ask your doctor to review your medications to identify cause
once
Rule out kidney stones with your doctor
once
If male, schedule a prostate exam
once
4

4
Serum free light chains increased ratio normal. lambda immunofixation with 4% m spike in beta 2 region in urine only. recommended next step 4 anemia?

Serum free light chains increased ratio normal. lambda immunofixation with 4% m spike in beta 2 region in urine only.  recommended next step 4 anemia?

Spike in UPEP: If you have an abnormal M spike on your urine protein electrophoresis (UPEP), that suggests there is some abnormal cells making excess gamma globulin ( a monoclonal gammopathy). A next step would normally include a bone marrow aspirate and biopsy - this reveals what the abnormality of the blood forming cells causing this is. ...Read more

5

5
Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

See 1 more doctor answer
7

7
Pain every time I go urine?

Pain every time I go urine?

Time to get checked: Depending on your other symptoms, there are several possibilities. It is very common for women to get urine infections, especially if you've only had the pain for a few days. Try cranberry juice and emptying your bladder frequently over the next 2 days. If your symptoms do not improve, you should go to your doctor to get tested as you may need antibiotics. ...Read more

8

8
My urine is very very hot why?

My urine is very very hot why?

Feels hot to you: Could symptomatically signify a urinary tract infection which can easily be checked. Actual temperature of urine can not differ from your own core temperature. ...Read more

9

9
What causes cloudy white urine?

What causes cloudy white urine?

To see an M.D.: Several causes, for this. Unless the urine is checked and examined the patient, hard to tell. ...Read more

10

10
Is urine too dilute a bad thing ?

Is urine too dilute a bad thing ?

Yes: Excess urine excretion may be a sign of adrenal or kidney problem. You could also have a low adh (vasopressin). Also you could be overhydrated. ...Read more

See 1 more doctor answer