Doctor insights on:
Undifferentiated Connective Tissue Disease
I am being treated for undifferentiated connective tissue disease which can be debilitating during flares. Is it likely I will stay in this limbo diagnosis forever?
The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more
Mixture of many: It is a mixture of findings from a variety connective tissue diseases including systemic lupus erythematosus, rheumatoid arthritis, polymyositis and scleroderma. One does not have allof the symptoms at one time but can overlap from one to another with arthritis, rashes, internal involvement of lungs, heart, kidney less often. ...Read moreSee 1 more doctor answer
Type not clear: Undifferentiated connective-tissue disease (uctd) is a diagnosis applied to signs and symptoms that are consistent with a connective-tissue disease (ctd) but that do not fulfill the classification or diagnostic criteria for any one of the defined ctds such as (rheumatoid arthritis, lupus, etc..). ...Read moreSee 1 more doctor answer
A LOT!: Any connective tissue disease (ctd) is essentially autoimmune, in nature, meaning the body is attacking itself. 'undifferentiated' may mean it's not classified or not classifiable, but still bears the hallmarks of inflammation & autoimmunity. No one can really agree what fibromyalgia is or what it's cause(s) are, but it does not appear to be autoimmune. Treatments for the 2 are very different. ...Read more
How long does it take for plaquinil to start working for undifferentiated connective tissue disease?
I have had interstital cystitis for yrs & undifferentiated connective tissue disease--(not tied down to diagnosis yet). Do you think they are related?
It is a possibility: Although there isn't much is known about the cause of interstitial cystitis, it is a result of inflammation (unkown cause) of the bladder and/or urethral area. Mixed (undifferentiated) connective tissue disease is also an inflammatory condition of various tissues, including bladder etc..So, it is possible that the 2 r related, but relationship is not well-defined, yet. Consult your doc. Good luck. ...Read moreSee 1 more doctor answer
Is there any known/suspected relationship between. Undifferentiated connective tissue disease and mast cell activation syndrome ?
Unaware: I am not aware of such a connection ...Read more
Why do I wake up lightheaded? I have undifferentiated connective tissue disease & get flares of this. When a flare occurs, it starts when i wake up.
Maybe not MCTD!: Most patients with mctd have very mild illnesses, quite manageable on plaquenyl and perhaps low dose steroids. You may be having postural hypotension, which is common, but you should see someone in rheumatology when you flare, to see if an abnormailty can be documented! ...Read more
Is there any known/suspected relationship between. Undifferentiated connective tissue disease and mast cell activation syndrome ? How is uctd dx?
UCTD: Good question. Not sure. Sorry can't answer that one comfortably. ...Read more
This largely relates to cancer cells and is a description of how variant the structure and division pattern is from normal cells. An anaplastic cells has weird internal componens, sometimes extra nuclei, and a bizarre pattern of division. They are usually more rapidly dividing and are a serious type of abnormality ...Read more
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