Top
20
Doctor insights on: Uncommon Causes Of Elevated Thyrotropin Receptor Antibodies

Share
1

1
What causes elevated histone antibody levels in bloodworm?

What causes elevated histone antibody levels in bloodworm?

???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more

Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


2

2
Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)? Autoantibodies?

Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)?  Autoantibodies?

TRPA1 Gene Family: The best article i've read on this gene family is ===> http://www.Genecards.Org/cgi-bin/carddisp.Pl?Gene=trpa1. The clinical significance of mutations in this gene has been related to caffeine and nicotine sensitivity disorders, and rare environmentally-triggered pain disorders. The complete function of this gene family is not known. ...Read more

3

3
Is there a way to distinguish between infectious versus autoimmune causes of lymphocytic hypophysitis? Can infectious cause result in isolated acth deficiency with low prl and tsh, normal lh, fsh, gh?

Is there a way to distinguish between infectious versus autoimmune causes of lymphocytic hypophysitis? Can infectious cause result in isolated acth deficiency with low prl and tsh, normal lh, fsh, gh?

Rare: Please seek endocrine evaluation. Anti pituitary antibodies are not commercially avaiable (yet). Histiocytosis and TB in addition to other infiltrative diseases can affect pituitary function. ...Read more

See 1 more doctor answer
4

4
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

See 2 more doctor answers
5

5
Is the risk of thyroid carcinoma increased with diagnosis of hashimoto thyroiditis when multiple thyroid adenomas are present. Tyab 2470?

Is the risk of thyroid carcinoma increased with diagnosis of hashimoto thyroiditis when multiple thyroid adenomas are present. Tyab 2470?

Not if they function: If the adenomas are "cold" or do not function, then they are likely to be malignant. They do not show up on radionuclide scan because they do not function. Otherwise they are unlikely to be malignant. However, since you have many of them, you likely need and should get further workup, like aspiration biopsy, etc., along with treatment for your hashimoto's. ...Read more

6

6
What are the cuases of elevated anticardiolipin antibodies?

What are the cuases of elevated anticardiolipin antibodies?

Auto-immunity: Anticardiolipin antibodies are commonly present in systemic lupus and related disorders. These antibodies are also present due to syphilis. See this site for more info. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc95774/. ...Read more

7

7
Does an elevated level of thyroglobulin antibodies and calcitonin mean cancer?

Does an elevated level of thyroglobulin antibodies and calcitonin mean cancer?

Elevation.: Thyroglobulin autoantibodies can be present in benign/malignant thyroid disease. If you have a diagnosis of papillary or follicular cancer, their presence can interfere with thyroglobulin as a tumor marker. If autoantibodies rise, that can be a surrogate marker for cancer recurrence. As for calcitonin, it's elevation is clinically significant in cases of primary or recurrent medullary cancer. ...Read more

See 1 more doctor answer
8

8
Some research suggests patients with cushings can have positive anti-pituitary antibodies targeting acth producing cells and this autoimmunity can stimulate acth adenoma formation. Is this correct?

Doubt it: People with pituitary adenomas of all sorts tend to have pituitary autoantibodies but these can't cause the mutations that cause the tumors ; are probably just the result for the normal gland being damaged. Since the type of tumor has no correlation with antibody presence, this supports this common-sense idea. New review pituitary. 15(4):490-4, 2012 dec. ...Read more

See 1 more doctor answer
9

9
43 yo f, afternoon cortisol high, cortisol suppression test high, CT of adrenal glands normal. Other causes of elevated cortisol?

43 yo f, afternoon cortisol high, cortisol suppression test high, CT of adrenal glands normal. Other causes of elevated cortisol?

Pituitary : Cortisol is under control of the pituitary. You need to know if the source is coming from the pituitary. We call this Cushing disease. See a specialist to work this up. Cushing's is one of the most difficult diagnosis to make, even for a specialist. ...Read more

12

12
What causes elevated calcitriol (108.5 pg/mL) with elevated serum Ca, normal PTH. No granuloma disease.

What causes elevated calcitriol (108.5 pg/mL) with elevated serum Ca, normal PTH. No granuloma disease.

Measure 25(OH)D: Calcitriol, 25(OH)2D, is usually elevated in granulomatous diseases such as sarcoidosis, in lymphomas or in primary hyperparathyroidism, as you suggest. Calcitriol is quite influenced by intestinal absorption of calcium; 25(OH)D is the vitamin D metabolite usually measured (not DI-hydroxy/2D). Add a 25(OH)D measurement & work with your doctor to pursue the other causes of hypercalcemia. Good luck! ...Read more

13

13
What are normal levels of thyroid antibodies?

What are normal levels of thyroid antibodies?

Thyroid antibodies: These usually are performed by commercial labs. They give the normal ranges - usually less than 20 units. ...Read more

14

14
Is single solid thyroid nodule more/less likely to be malignant in presence of just-id'd suppressed tsh, slightly elevated free t3/free t4, tsi of 313?

Is single solid thyroid nodule more/less likely to be malignant in presence of just-id'd suppressed tsh, slightly elevated free t3/free t4, tsi of 313?

Less likely: Suppressed TSH means hyperfunctioning thyroid gland. Most of the time that lowers the risk of cancer but does not eliminate the risk and the nodule may still need to be biopsied. ...Read more

See 1 more doctor answer
15

15
Thyroseq neg for mutations But interpret with caution due to marginally low expression of thyroid cell specific markers.Odds higher for benign nodule?

Thyroseq neg for mutations But interpret with caution due to marginally low expression of thyroid cell specific markers.Odds higher for benign nodule?

Probably normal: This is best discussed with your endocrinologist who can put it in perspective. If necessary you ultrasound and even biopsy can guide your therapy. ...Read more

16

16
Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis. ...Read more

19

19
What can cause high thyroid antibodies with normal tsh?

Thyroid antibodies: Hashimotos disease - its an autoimmune disorder causing thyroid inflammation. An ultrasound should be performed to detect thyroid nodules. It can cause thyroid dysfunction ie TSH abnormalities over time. ...Read more

20

20
Could mthfr c667t mutation be the cause of elevated mcv, mch, and b12?

Could mthfr c667t mutation be the cause of elevated mcv, mch, and b12?

No: Look for another cause. 30% of white people have one dose and 5% have two. There are some correlations found by some groups but most people in the pathology community do not believe this is sufficient to explain clinical illness. I also see that you are on Methotrexate which can raise mcv, and an elevated B12 means nothing. ...Read more

See 2 more doctor answers

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more