Doctor insights on:
Uncommon Causes Of Elevated Thyrotropin Receptor Antibodies
???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more
An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more
Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)? Autoantibodies?
TRPA1 Gene Family: The best article i've read on this gene family is ===> http://www.Genecards.Org/cgi-bin/carddisp.Pl?Gene=trpa1. The clinical significance of mutations in this gene has been related to caffeine and nicotine sensitivity disorders, and rare environmentally-triggered pain disorders. The complete function of this gene family is not known. ...Read more
Is there a way to distinguish between infectious versus autoimmune causes of lymphocytic hypophysitis? Can infectious cause result in isolated acth deficiency with low prl and tsh, normal lh, fsh, gh?
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?
Is the risk of thyroid carcinoma increased with diagnosis of hashimoto thyroiditis when multiple thyroid adenomas are present. Tyab 2470?
Not if they function: If the adenomas are "cold" or do not function, then they are likely to be malignant. They do not show up on radionuclide scan because they do not function. Otherwise they are unlikely to be malignant. However, since you have many of them, you likely need and should get further workup, like aspiration biopsy, etc., along with treatment for your hashimoto's. ...Read more
Elevation.: Thyroglobulin autoantibodies can be present in benign/malignant thyroid disease. If you have a diagnosis of papillary or follicular cancer, their presence can interfere with thyroglobulin as a tumor marker. If autoantibodies rise, that can be a surrogate marker for cancer recurrence. As for calcitonin, it's elevation is clinically significant in cases of primary or recurrent medullary cancer. ...Read moreSee 1 more doctor answer
Some research suggests patients with cushings can have positive anti-pituitary antibodies targeting acth producing cells and this autoimmunity can stimulate acth adenoma formation. Is this correct?
Doubt it: People with pituitary adenomas of all sorts tend to have pituitary autoantibodies but these can't cause the mutations that cause the tumors ; are probably just the result for the normal gland being damaged. Since the type of tumor has no correlation with antibody presence, this supports this common-sense idea. New review pituitary. 15(4):490-4, 2012 dec. ...Read moreSee 1 more doctor answer
43 yo f, afternoon cortisol high, cortisol suppression test high, CT of adrenal glands normal. Other causes of elevated cortisol?
What illness could explain ELEVATED C3 and C4 complement serum levels in the presence of angioedema? ANA and Rheum Arth Factor both negative.
What causes elevated calcitriol (108.5 pg/mL) with elevated serum Ca, normal PTH. No granuloma disease.
Measure 25(OH)D: Calcitriol, 25(OH)2D, is usually elevated in granulomatous diseases such as sarcoidosis, in lymphomas or in primary hyperparathyroidism, as you suggest. Calcitriol is quite influenced by intestinal absorption of calcium; 25(OH)D is the vitamin D metabolite usually measured (not DI-hydroxy/2D). Add a 25(OH)D measurement & work with your doctor to pursue the other causes of hypercalcemia. Good luck! ...Read more
Is single solid thyroid nodule more/less likely to be malignant in presence of just-id'd suppressed tsh, slightly elevated free t3/free t4, tsi of 313?
Thyroseq neg for mutations But interpret with caution due to marginally low expression of thyroid cell specific markers.Odds higher for benign nodule?
Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?
Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis. ...Read more
Will running lower catecholamine level? I produce high levels of catecholamine. The reason is still unknown after testing for abnormal mass in glands.
What could cause/explain significantly elevated (4.5x the norm range)plasma norepinephrine in blood test, but normal urinary norepinephrine levels?
No: Look for another cause. 30% of white people have one dose and 5% have two. There are some correlations found by some groups but most people in the pathology community do not believe this is sufficient to explain clinical illness. I also see that you are on Methotrexate which can raise mcv, and an elevated B12 means nothing. ...Read moreSee 2 more doctor answers
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