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Doctor insights on: Tysabri Side Effects

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What percentage of MS patients are on tysabri (natalizumab)? Is there a big chance of bad side effects?

What percentage of MS patients are on tysabri (natalizumab)? Is there a big chance of bad side effects?

Answer continues...: If, you have tested negative for jc virus antibodies, your chance of getting pml is around 0.09/1, 000. On the other hand, if you have tested positive for jc virus antibodies, have been on tysabri (natalizumab) therapy for over two years and have prior exposure to immunosuppressant therapies, such as azathioprine, methotrexate, micophenolate, Cyclophosphamide or mitoxantrone, your risk becomes 11.1/1000. ...Read more

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Which is better? Interferon or tysabri (natalizumab)?

Which is better? Interferon or tysabri (natalizumab)?

NO contest: Tysabri (natalizumab) is the second most potent MS drug on the market, but it has a risk, as can potentially cause Progressive Multi-focal Encephalopathy, and possibly melanoma. Interferons are drugs of the past, and being phased out over time, due to lack of efficacy, but they are quite safe in most patients. ...Read more

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What is the active ingredient of tysabri (natalizumab)?

I'm puzzled: The "active ingredient" in Tysabri is Tysabri. The generic name is natalizumab. This isn't Alka-Seltzer we're dealing with; it's a highly purified intravenous drug. Do I misunderstand your question? ...Read more

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What are the benefits of tysabri (natalizumab) v. Other MS drugs?

What are the benefits of tysabri (natalizumab) v. Other MS drugs?

Hard to answer: Tysabri (natalizumab) is a potentially effective treatment for MS but your question would be difficult to answer. Tysabri (natalizumab) is approved for the treatment of aggresive or refractory MS where other equally effective medications have not worked. This is because of a possibly fatal side effect called pml which may cause more damage than the disease. Use requires an experienced doctor and close monitoring. ...Read more

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Does anyone know where a tysabri (natalizumab) infusion center is?

Does anyone know where a tysabri (natalizumab) infusion center is?

MS: Typically, most medical schools use infusion centers on site. Many outpatient cancer centers can infuse tysabri (natalizumab) also. Many community hospitals can provide this service. ...Read more

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Does the benefit of tysabri (natalizumab) outweigh the risk of PML ?

Does the benefit of  tysabri (natalizumab) outweigh the risk of PML ?

Individualized: Tysabri/natalizumab is an immunosuppressant used in the treatment of relapsing forms of MS. PML (progressive multifocal leukoencephaolopathy),the result of JC virus infection, is a disastrous side effect.The decision to use this drug has to be very cautiously assessed by the MS patient & his doctor & administered through a restricted program. Risk/benefit analysis is complicated & challenging. ...Read more

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Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

MS: Tysabri (natalizumab) is a well tolerated medicine, infused once monthly. It is clearly the most effective ms drug on the market but has a risk of a life threatening infection, pml. Does reduce relapses, disabiity, and MRI lesions, and seems to improve fatique and depression also. ...Read more

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Is "a sense of impending doom" a symptom that something could be wrong?  am taking bupropian and tysabri (natalizumab). Should I see a dr?

Is "a sense of impending doom" a symptom that something could be wrong?  am taking bupropian and tysabri (natalizumab). Should I see a dr?

See a doc: A sense of impending doom is one of the symptoms of a panic attack, though you do not mention other symptoms. First see your medcal doc and if all is well, see a psychiatrist. ...Read more

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