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Doctor insights on: Tysabri

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What are the benefits of tysabri (natalizumab) v. Other MS drugs?

What are the benefits of tysabri (natalizumab) v. Other MS drugs?

Hard to answer: Tysabri (natalizumab) is a potentially effective treatment for MS but your question would be difficult to answer. Tysabri (natalizumab) is approved for the treatment of aggresive or refractory MS where other equally effective medications have not worked. This is because of a possibly fatal side effect called pml which may cause more damage than the disease. Use requires an experienced doctor and close monitoring. ...Read more

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Tysabri (natalizumab). Do you know about this pill?

Tysabri (natalizumab). Do you know about this pill?

MS: Tysabri (natalizumab) is not a pill. Gilenya is the sole oral agent on the market at this time. Tysabri (natalizumab) is infused through the vein once monthly. Although the most effective med on the market, there is risk of a deadly infection after use for greater than 2 years. Your neurologist can help decide whether this is the drug for you. ...Read more

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Many neurologists in australia are claiming tysabri (natalizumab) (for ms) is safe during pregnancy due to new research and studies. What are your opinions?

Many neurologists in australia are claiming tysabri (natalizumab) (for ms) is safe during pregnancy due to new research and studies. What are your opinions?

NOT FULLY KNOWN: Pregnancy recommendations for virtually all ms drugs but one (copaxone), suggest discontinuation of the medicine prior to becoming pregnant due to risk of possible miscarriage or fetal malformation. Certainly possible that drugs in the c and lower categories could be risky, but more often than not, normal babies are the outcome. Yet, i would not declare tysabri (natalizumab) safe for pregnancy, at this time. ...Read more

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What percentage of MS patients are on tysabri (natalizumab)? Is there a big chance of bad side effects?

What percentage of MS patients are on tysabri (natalizumab)? Is there a big chance of bad side effects?

Answer continues...: If, you have tested negative for jc virus antibodies, your chance of getting pml is around 0.09/1, 000. On the other hand, if you have tested positive for jc virus antibodies, have been on tysabri (natalizumab) therapy for over two years and have prior exposure to immunosuppressant therapies, such as azathioprine, methotrexate, micophenolate, Cyclophosphamide or mitoxantrone, your risk becomes 11.1/1000. ...Read more

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My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than i thought?

My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than i thought?

Management: The risk of PML becomes more significant the longer you take Tysabri, (natalizumab) and 2yrs is the turning point, but risk is still low, about 1 in 90. However, for some pts, this still is too high, and they switch to Gilenya at 2yrs. This is a calculated gamble, and should be your decision, not just your doctor's. The severity of your MS is just one part of this, so talk at length with your neurologist. ...Read more

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Tysabri (natalizumab). Do you know about this pill?

MS: Tysabri (natalizumab) is not a pill. Gilenya is the sole oral agent on the market at this time. Tysabri (natalizumab) is infused through the vein once monthly. Although the most effective med on the market, there is risk of a deadly infection after use for greater than 2 years. Your neurologist can help decide whether this is the drug for you. ...Read more

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Which is better? Interferon or tysabri (natalizumab)?

Which is better? Interferon or tysabri (natalizumab)?

NO contest: Tysabri (natalizumab) is the second most potent MS drug on the market, but it has a risk, as can potentially cause Progressive Multi-focal Encephalopathy, and possibly melanoma. Interferons are drugs of the past, and being phased out over time, due to lack of efficacy, but they are quite safe in most patients. ...Read more

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What is the active ingredient of tysabri (natalizumab)?

I'm puzzled: The "active ingredient" in Tysabri is Tysabri. The generic name is natalizumab. This isn't Alka-Seltzer we're dealing with; it's a highly purified intravenous drug. Do I misunderstand your question? ...Read more