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Doctor insights on: Tylenol Toxicity

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Why is nac (n-acetylcystein) administered to antidote tylenol (acetaminophen) toxicity instead of using gluathione exogenous supplement directly?

Why is nac (n-acetylcystein) administered to antidote tylenol (acetaminophen) toxicity instead of using gluathione exogenous supplement directly?

Standard protocol ;: Good question. Nac is well-proven to work ; is the standard protocol. Glutathione might work as well or better but i'm unaware of any studies showing it works. Also, standard glutathione is poorly absorbed orally. It might work well given IV but has a short shelf-life ; is not generally available in er's. See http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc436956/ good luck with your condition! ...Read more

Dr. Heidi Fowler
1,399 doctors shared insights

Tylenol (Definition)

Acetaminophen (tylenol) is a non-steroidal anti-inflammatory which is a ...Read more


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650-1000 mg of Tylenol (acetaminophen) on daily basis for the last 2 months planing keep doing it. Is there a risk of toxicity for my cirrhotic liver?

650-1000 mg of Tylenol (acetaminophen) on daily basis for the last 2 months planing keep doing it. Is there a risk of toxicity for my cirrhotic liver?

Acetaminophen/liver: Health care professionals often recommend avoiding the use of acetaminophen in patients with liver disease or cirrhosis, whereas NSAIDs are more commonly endorsed. Case reports have shown long-term ingestion of supratherapeutic doses (>4 g/d) of acetaminophen in patients without known liver disease, and therapeutic doses in alcoholic patients without cirrhosis, cab result in acute liver failure. ...Read more

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I vomited dark yellowish green bile. I also hurt on the right side of my stomach. I've been taking tylenol (acetaminophen 500), could I have toxicity?

I vomited dark yellowish green bile. I also hurt on the right side of my stomach. I've been taking tylenol (acetaminophen 500), could I have toxicity?

Concerned.: You need to be evaluated by a physician. Your potential problems include gallbladder infections, ulcers, pancreas inflammation and depending on the amount of tylenol (acetaminophen) taken, tylenol (acetaminophen) overdose. ...Read more

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Which of these drug have less toxicity & which has an effective anelagesic effect, acetaminophen oribuprofren?

Which of these drug have less toxicity & which has an effective anelagesic effect, acetaminophen oribuprofren?

Drug toxicity: Relating to your question, Acetaminophen toxicity is usually cumulative, Ibuprofen and related non-steroidal agents (like aleve/naprosyn) can cause irritation of the lining of the stomach(gastritis) even in small doses, especially if taken on an empty stomach. Please minimize use of all over the counter medications for your safety. ...Read more

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Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

After research: Checked in epocrates which is a respected source of drug information showed nothing in the way of interaction between acetaminophen and trileptal. before taking any action check with your doctor and or pharmacist. Good luck ...Read more

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Does milk thistle really help the liver? I take around 650mg acetaminophen almost daily and i was told milk thistle would help prevent any toxicity

Does milk thistle really help the liver? I take  around 650mg acetaminophen almost daily and i was told milk thistle would help prevent any toxicity

Milk thistle: Milk thistle is an herbal extract that is reputed to ameliorate liver injury or disease; it can help, just be sure you get a high quality product; avoid alcohol most importantly; take anti-oxidants, also; ...Read more

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I take 900mg of lithium. Just had gallbladder out yesterday, doc gave me norco (hydrocodone and acetaminophen) and 600 ibprofrin so 4x a day 1800mg ibprofrin make lithium toxic??

I take 900mg of lithium. Just had gallbladder out yesterday, doc gave me norco (hydrocodone and acetaminophen) and 600 ibprofrin so 4x a day 1800mg ibprofrin make lithium toxic??

No worries: Norco (hydrocodone and acetaminophen) and ibuprofen should not react with lithium. Take the pain medication only if you need it! If you can tolerate mild discomfort after the operation there is no need to even bother with pain medication. Otherwise, don`t worry about an interaction :) ...Read more

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Which is best for bodyache and lower in toxicitym, ibuprofen or acetaminophen?

Don't self medicate: As stated before taking anything have yourself evaluated by a physician. Don't take a short cut. ...Read more

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I have a knot in my lower right back that hurts Tylenol won't help n I can't take ibprofuen what do I need to do?

I have a knot in my lower right back that hurts Tylenol won't help n I can't take ibprofuen what do I need to do?

Get examined: If you are still having issues I suggest a physical exam. If you are not allergic, I suggest Aleve, 1 tablet every 8 rs and simultaneous use of BioFreeze sport linamint, ...Read more

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Would you die from 10 tylenol (acetaminophen)?

Would you die from 10 tylenol (acetaminophen)?

Tylenol (acetaminophen): This really depends on the dose of acetaminophen. A dose of 7gm at one time will put you into severe liver compromise. Current recommendation of the the aps is not to exceed 2-2.5gm/day, fda guide still states 4gm/day. An overdose will compromise the liver and if it does not recover then you could die. ...Read more

Dr. Alvin Stein
2,039 doctors shared insights

Acetaminophen (Definition)

Acetaminophen (tylenol) is a non-steroidal anti-inflammatory which is a ...Read more


Toxicity (Definition)

Toxicity is the degree to which a drug or a substance can harm ...Read more