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Doctor insights on: Two Down Syndrome People Have A Baby

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Dr. Kathryn Akin
659 doctors shared insights

Down Syndrome (Definition)

A genetic Chromosome 21 disorder causing ...Read more


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If my grandma have Down syndrome and me and my parents don't, is it possible that my child have down syndrome?

If my grandma have Down syndrome and me and my parents don't, is it possible that my child have down syndrome?

Unlikely: The traditional 21 ds female is capable of having healthy babies and at least half would not have ds. Those healthy babies would not have more than 1% risk having a ds kid nor would their kids. Less than 2% of ds patients are balanced carriers of an extra piece or a 21, and the chance that they would have any normal kids (your parent) approaches zero. ...Read more

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Can you tell me if I am a carrier of fragile x will my son have higher chances of down syndrome?

Can you tell me if I am a carrier of fragile x will my son have higher chances of down syndrome?

No, risk of both: If you or dad have a blood relative with Down, your risk at delivery is 1%. if none, at 37 the risk at term is 1/226, and before 14 weeks 1/52 (many affected die before term). Risk for a male with Fragile X is ½ males, and for a carrier female, ½ females. You may have CVS to determine both. If termination is not an option, you may have preimplantation diagnosis for both, or a donor egg. ...Read more

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I am 24, and my tests indicate i'm at high risk having a Down syndrome baby. Should I have the amniocentesis?

I am 24, and my tests indicate i'm at high risk having a Down syndrome baby.  Should I have the amniocentesis?

Depends: Anyone is at risk for a baby with down syndrome. If testing shows that you are at high risk, the risks of having a baby with down synedrome are higher than the risk of pregnancy loss. The loss with amniocentesis is only 1 in 1600 in experienced hands. The only way to know whether your baby is affected or not is to have an amniocentesis. ...Read more

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I had a previous down syn pregnancy,translocation type,im afraid all my babies will have DS?is it possible that i have same chromosome translocation?

I had a previous down syn pregnancy,translocation type,im afraid all my babies will have DS?is it possible that i have same chromosome translocation?

Possible: Yes it is possible you have a chromosomal abnormality. It's also possible that this was an isolated new event in that pregnancy. It would be an excellent idea to consult with a geneticist and/or a maternal-fetal medicine specialist prior to another conception to decide if you want or need to be tested and what all of your options are with another pregnancy. SO much info is available to you! ...Read more

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If my grandmother and my mom are carriers for fragile x syndrome and both have had a child that had it could i be at risk of being a carrier.?

If  my grandmother and my mom are carriers for fragile x syndrome and both have had a child that had it could i be at risk of being a carrier.?

Yes: You get one normal x chromosome from your unaffected dad & one ?X from your carrier mom. Your mom has a 50% risk of passing the carrier state to you. You can have your chromosomes studied to see if you are a carrier.Consultation with a geneticist may be a option if you have other questions. Your pcp may be able to order a fragile x study for you but it is usually sent out to a specialty lab. ...Read more

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Is there a condition where two races can't have a baby ?I've had four miscarriages with a person from another race and one live birth with a person of my own race. I am 6 weeks pregnant now.

Is there a condition where two races can't have a baby ?I've had four miscarriages with a person from another race and one live birth with a person of my own race. I am 6 weeks pregnant now.

No: It's possible that the specific person you were trying to get pregnant with wasn't compatible with you, meaning that when your chromosomes combined, there were problems with formation of viable pregnancy. Also possible that he was cause for infertility (men are 30% of time) and not you at all. But none of this has anything to do with race. ...Read more

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I'm a 34 female who will be 35 by the time my baby is born. What are my chances of having a down sydrome baby?

I'm a 34 female who will be 35 by the time my baby is born. What are my chances of having a down sydrome baby?

Varies some: If you are speaking of traditional 21 trisomy the cited frequency is 1/270. There are other forms of down syndrome ( translocation, mosaic) that occur less often. ...Read more

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I just recently found out i'm pregnant with my 3rd child. Two of my children are from a previous marriage and I am now pregnant with my fiance's child and he is 38 I will be 29 in a week. My 2nd child has trisomy 21 downs syndrome. Everyone I talk to keep

I just recently found out i'm pregnant with my 3rd child. Two of my children are from a previous marriage and I am now pregnant with my fiance's child and he is 38 I will be 29 in a week. My 2nd child has trisomy 21 downs syndrome. Everyone I talk to keep

MaterniT21.: Your question was cut-off - but, if i understand correctly, you are concerned about the risk of Down syndrome in your current fetus because of your prior infant with down. My answer is easy: take folate, (folic acid) get genetic counseling and consider the maternit21 non-invasive test by sequenom (or others similar to it now commercially available) to determine this fetus' risk for down syndrome. Best of luck! ...Read more

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My brother has long qt syndrome which has caused him to faint a fem times. Can I have long qt syndrome and never have any symptoms?

My brother has long qt syndrome which has caused him to faint a fem times. Can I have long qt syndrome and never have any symptoms?

Yes: If your brother has been formally diagnosed, you should be screened. An ECG can typically make the diagnosis. If a gene was identified in your brother you should be tested to see if you have it as well. Unfortunately, sometimes the first symptom can be very dangerous. ...Read more

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Can a 20 week Anatomy ultrasound pick up down syndrome in the baby ? I have an increased risk of a 1 in 89 chance of having my baby born with DS

Can a 20 week Anatomy ultrasound pick up down syndrome in the baby ? I have an increased risk of a  1 in 89 chance of having my baby born with DS

Didn't you ask this?: Your risk assessment was obsolete, Ultrasound detection of Down at 20 weeks misses many. Demand a test of freei fetal DNA in your blood sample--your PCP can order the Harmony test from Ariosa: call 1-855-9-ARIOSA (855-927-4672) In over 15,000 pregnancies they detected 100% of Down syndrome and the chance of a false positive was less than 1 in 1000. Results in 4 to 8 days. ...Read more

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I have 2 kids one has a major heart defect and has aspergers syndrome. My other was born 100% healthy.What are my odds of having another healthy baby?

I have 2 kids one has a major heart defect and has aspergers syndrome. My other was born 100% healthy.What are my odds of having another healthy baby?

It Depends: There may be more factors to consider before arriving at reasonably predictable odds. I suggest, you seek out a medical geneticist for your best answer. There are dna tests needed along with a precise history from both sides of the family; then the odds can be calculated. It would, in my opinion, be unethical to give you the answer you want without having much more data. Good luck. ...Read more

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Will all my kids have aspergers syndrome id one already does?

Will all my kids have aspergers syndrome id one already does?

Higher Risk: If you have one child wtih asperger's syndrome, there is a higher risk of another child having similar problems compared to the general population. However, the chances are still much greater that your other children will not have the same problem. You would also want to be aware of an increased risk of adhd and anxiety-related problems in your other children. ...Read more

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I am 28 years old and just received news from my obgyn that I have a 1:50 chance to have a baby with down syndrome. I am extremely worried.?

I am 28 years old and just received news from my obgyn that I have a 1:50 chance to have a baby with down syndrome.  I am extremely worried.?

Statistics!: Try to remember that a one-in-fifty chance of having a baby with down syndrome is the same as a forty-nine-out-of-fifty chance that you won't. Depending on how far along you are, you may be able to have a test that will tell you for certain, i.e., through amniocentesis or chorionic villous sampling. Please talk to your health care provider for more information and hopefully, reassurance. Lgromkomd. ...Read more

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Wht % that a type I diabetic mther and celiac father would have kid with one or both conditions?

Wht % that a type I diabetic mther and celiac father would have kid with one or both conditions?

Unknown: There is no way to put a number on the chance of having one or both of these conditions. Genetics definitely increase the risk but there is no guarantee that the child will get one, both or none of these ailments. ...Read more

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My baby daddy mon has a daughter that has Down syndrome but is only from his mom not dad is there a change my baby going to have Down syndrome too?

My baby daddy mon has a daughter that has Down syndrome but is only from his mom not dad is there a change my baby going to have Down syndrome too?

Unlikely: With the most common chromosomal abnormality causing DS, you have no increased risk. In a much less common form ( unbalanced translocation), your baby's father has a chance of carrying it. I recommend finding out what the chromosomal abnormality was, and discuss it with your OB or a genetics specialist. ...Read more

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Could you tell me what happens when two Down syndrome people have a baby?

Seldom happens: Most down syndrome males are functionally sterile. Rare mosaic individuals have potential for fertility but data is not available for comprehensive review. Ds women enter puberty & childbearing at the usual time & can give birth.Data suggests less than 1/2 their offspring will be ds due to miscarriage of some ds embryos.Most are born prematurely and by c-section. ...Read more

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Am 28y and my first baby is down , its bciz random mutation what the chance to have another one with down ?!

Am 28y and my first baby is down , its bciz random mutation what the chance to have another one with down ?!

About 1% added : The basic of a trisomy 21 ds varies with age, being 1/800 at 30-34, 1/270 at 35-40.A previous ds birth adds 1% if it was a traditional trisomy 21 ds . A discussion with a geneticist affiliated with a med school or kids hospital could provide with all your risk factors in detail. ...Read more

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24 years old male ,my gf is 16 weeks pregnant, my older sister just got dx with zellweger syndrome , what are the odds i that carry it or my child?

24 years old male ,my gf is 16 weeks pregnant, my older sister just got dx with zellweger syndrome , what are the odds i that carry it or my child?

Chances of carrying:: 50% for you (if both your parents carry the gene), 25% for baby fetus if you but not your wife carry it. Zellweger syndrome is the most severe form of the Zellweger spectrum disorders. Inheritance is "autosomal recessive", which means both copies of the gene have mutations. Usually, the patient's parents each carry one copy of the mutated gene, but carriers typically do not show signs or symptoms. ...Read more

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