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Doctor insights on: Two Antihistamines

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Can you tell me if i could take two antihistamines at once?

Can you tell me if i could take two antihistamines at once?

Yes but why: If you take two antihistamines at once you will bring out the less desirable side effects such as drowsiness and dry mouth. There is really no benefit from this and could lead to an overdose if you did this long term. Its best to take one at a time give it a few days to determine if that antihistamine is working and if not change to another. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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I have had a skin crawling sensation for a month..Dr prescribed two antihistamines. Neither worked. Blood work is fine. No rash, bumps or bites. ?

I have had a skin crawling sensation for a month..Dr prescribed two antihistamines.  Neither worked. Blood work is fine. No rash, bumps or bites. ?

Which bloodwork fine: There are several different tests that should be considered part of every workup for creepy crawly skin. In my opinion only a very few people with similar complaints get all the recommended tests the first time around. Then, patients will always say, "but all the blood is fine..." But that's assuming that all the relevant bloodwork was done. So, name the tests and we'll see. What's next? ...Read more

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Is it safe to take two types of antihistamines togeather ?

Is it safe to take two types of antihistamines togeather ?

Probably not: It is not a good idea because of the increased risk of side effects from taking multiple similar meds. ...Read more

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Is it safe to take two 24-hour antihistamine pills at the same time?

Is it safe to take two 24-hour antihistamine pills at the same time?

Depends: It could be safe or not depending on the total dose you are taking in one day. By the way safe is conventionally defined, it will probably be safe and it will at most make you a little sleepy and contribute to reduced motor coordination, but in the context of operating a motor vehicle this could make a difference. You may want to see a doctor to get your allergies evaluated medically. Stay safe! ...Read more

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I'm due to have a thyroid scan in 3 days. Yesterday, I took two 25 mg antihistamine pills. Will this affect the results?

I'm due to have a thyroid scan in 3 days.  Yesterday, I took two 25 mg antihistamine pills.  Will this affect the results?

No, it should not.: The half life of most antihistamines should be less than 24 hrs and should be out of the system by then. I would check with the radiology center to confirm their policy. I would also avoid any more antihistamines until the time of testing. ...Read more

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Extremely itchy roof of mouth towards the back for two weeks now. Antihistamines don't relieve symptoms.

Extremely itchy roof of mouth towards the back for two weeks now. Antihistamines don't relieve symptoms.

Toothpaste?: You may be allergic to things you use on your mouth such as certain toothpaste or mouthwash. Cinnamon is likely the most common allergen. Try switching to different toothpaste or mouth wash for 10 days and observe for any changes. It is unlikely to be from food allergy which does not last this long. ...Read more

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I understand xyzal (levocetirizine) and dallergy are both antihistamines, but what is the difference between the two?

Drowsiness: D'allergy is one of the older antihistamines that are more likely to cause drowsiness. Also, xyzal (levocetirizine) lasts much longer; you will control your symptoms better over time xyzal (levocetirizine). ...Read more

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Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more