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Doctor insights on: Tuberous Sclerosis Eye

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What causes tuberous sclerosis?

What causes  tuberous sclerosis?

Genetic mutations: These people have a genetic mutation at one of two loci TSC1 or TSC2 (hamartin and tuberin). A second mutation in a particular cell results in creation of a tumor. No two TS patients are alike and the severity of the illness varies tremendously. It's not curable, but it's often manageable. Best wishes. ...Read more

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Dr. Julie Abbott
3 doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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What is tubular sclerosis (or tuberous sclerosis)?

What is tubular sclerosis (or tuberous sclerosis)?

Neurological disorde: Tuberous sclerosis is a disorder involving brain structure, skin manifestations and cognitive function. Brain malformations called tubers are characteristic. Skin abnormalities of sebaceous adenomas and subungual fibromas. See a neurologist for more information. ...Read more

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Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people. Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more

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What is amyotrophic lateral sclerosis (als)? 

What is amyotrophic lateral sclerosis (als)? 

Motor neuron disease: A disorder of misfolded proteins, attacking nerve cell bodies in spinal cord and brain. Tends to involve weakness not numbness, and can affect legs and arms with flickering of muscles, loss of muscle mass, and evenually problems with breathing and swallowing. Unfortunately, there is no cure, and it preserves awareness. Gratefully, it is relatively rare. ...Read more

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Is multiple sclerosis hereditary?

Is multiple sclerosis hereditary?

Complex: Multiple sclerosis is an issue of genetic susceptibility, not the usual heredity, and risk runs about 3-5% if mother has it, 1-2% if father has it. But without specific environmental triggers, the disease will be unlikely to manifest. ...Read more

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Is optic neuritis always caused by multiple sclerosis?

Is optic neuritis always caused by multiple sclerosis?

Not always: But, if there is but one MRI white matter lesion associated with optic neuritis, about 75% of pts have developed clinically definite ms by 14 years. In other words, you may need followup for a period of time if you have suffered optic neuritis. Find an experienced ms specialized neurologist and discuss your situation. ...Read more

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Is optic neuritis sometimes caused by multiple sclerosis?

Is optic neuritis sometimes caused by multiple sclerosis?

No: Though optic neuritis might be the first presentation in someone who will develop ms, there are many times when it is simply optic neuritis. A thorough history and examination by a neurologist can help address for you whether you might already have ms, or simply optic neuritis. ...Read more

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Is progressive supranuclear palsy a demyelinating disease?

Is progressive supranuclear palsy a demyelinating disease?

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more

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Could kids get amyotrophic lateral sclerosis?

Could kids get amyotrophic lateral sclerosis?

Similar : But most childhood illnesses which affect the motor neuron, like als, are quite rare, and more hereditary in origin. A variety of such disorders cause weakness in very young children, and adolescents and seem similar in outcome. Also, polio used to affect many children but is almost unknown in usa today. ...Read more

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Optic neuritis (nmo) or multiple sclerosis (ms)? What are the different victims?

Optic neuritis (nmo) or multiple sclerosis (ms)? What are the different victims?

Say what???: This question is confusing! optic neuritis (abbreviated on) is one of many symptoms of ms and results from inflammation in one or both optic nerves. It is one of the most common symptoms of ms and typically causes eye pain and decreased vision in one eye. It does not typically cause complete blindness. Multiple sclerosis (ms) is an autoimmune disorder of the center nervous system. See below. ...Read more

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Is multiple sclerosis a hereditary condition?

In part: Hereditary risk is one factor, but the interplay between genetic background and environment is likely in this disease. Identical twins studies show about a 30% risk for MS if one twin has the disease (certainly not 100%). Population studies show certain ancestry may increase or decrease risk (e.g. Northern european ancestry high, whereas asian, african, aboriginal very low). ...Read more

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Is amyotrophic lateral sclerosis sex-linked or a chromosomal error?

Is amyotrophic lateral sclerosis sex-linked or a chromosomal error?

ALS: Amyotrophic lateral sclerosis or ALS (lou gehrig's disease) is a central nervous system disease that causes progressive loss of strength and coordination. There are no known risk factors which predispose someone to developing als. Most commonly, the cause is unknown but in about 10% of cases, there is a genetic defect which leads to the problem. ...Read more

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How to detect multiple sclerosis eye symptoms?

How to detect multiple sclerosis eye symptoms?

Variable, but: Quite more common is optic neuritis, where unilateral loss of vision, associated with pain on eye motion, color desaturation, and possibly an abnormal pupillary light response. Other eye issues may include abnormal eye movements, such as nystagmus or double vision, and an item called internuclear ophthalmoplegia, which can associate both of the latter phenomena. ...Read more

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Can tuberous sclerosis be an auto immune disease?

Can tuberous sclerosis be an auto immune disease?

No: Ts is a genetic disorder that often arises from a new mutation. There are a variety of skin findings that can point to the diagnosis.It is the finding or "tubers" that can arise in the brain and other organs that can produce the most impairment in quality of life. It can be so mild that a college grad doesn't know they have it, or disabling by late childhood. ...Read more

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What symptoms does tuberous sclerosis manifest?

Small tumors: Ts is a genetic disease that causes small tumors to grow in various places in the body. Tumors can grow in the heart, eyes, brain, kidneys, as well as on the face and skin. Brain tumors will cause seizures, retardation, and hydrocephalus. Kidney tumors can cause kidney failure. Heart tumors can be present even at birth. New medication now available may shrink these tumors. ...Read more

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MRI brain results Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

MRI brain results  Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

Covering the bases: That signal that is seen in patients who age is seen very frequently. Most of the time it is what has become known as microangiopathic disease or small vessel disease. Demyelination and gliosis come with a more notable history. Gliosis or scarring and demyelination also produces symptoms that MRI is useful for. Depends on why you had the MRI in the first place. The first entity more common than 2 ...Read more

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Are multiple sclerosis and myasthenia gravis conditions of the neuroglia?

Are multiple sclerosis and myasthenia gravis conditions of the neuroglia?

Neither of them: Neither of these conditions is a condition of the neuroglia. To some extent, glial cells are involved in the repair of damage that occurs in MS. Myasthenia is a condition that occurs at the junction of the nerve and muscle, no glia cells are present there. ...Read more

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What conditions are similar to ocular myasthenia gravis?

What conditions are similar to ocular myasthenia gravis?

Muscle weakness: Other reasons for decreased use of muscles. This could be muscle diseases and neurological diseases. The usual clue is the occular involvement. This is where testing is done. Testing is to replace the loss of acetylcholine function like the tensilon test and other drugs that block the beakdown of acetylcholine by cholinesterase andtemporarily increases the level of acetylcholine and reverses it. ...Read more

Dr. Harry Vinters
221 doctors shared insights

Tuberous Sclerosis (Definition)

Tuberous sclerosis is a group of two genetic disorders that affect the skin, brain/nervous system, kidneys, and heart, and cause tumors to grow. The diseases are named after a tuber- or root-shaped ...Read more