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Doctor insights on: Tuberous Sclerosis Complex

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Is multiple sclerosis hereditary?

Is multiple sclerosis hereditary?

Complex: Multiple sclerosis is an issue of genetic susceptibility, not the usual heredity, and risk runs about 3-5% if mother has it, 1-2% if father has it. But without specific environmental triggers, the disease will be unlikely to manifest. ...Read more

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Dr. Hirenkumar Italia
3 doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people. Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more

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What causes tuberous sclerosis?

What causes  tuberous sclerosis?

Genetic mutations: These people have a genetic mutation at one of two loci TSC1 or TSC2 (hamartin and tuberin). A second mutation in a particular cell results in creation of a tumor. No two TS patients are alike and the severity of the illness varies tremendously. It's not curable, but it's often manageable. Best wishes. ...Read more

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What is tubular sclerosis (or tuberous sclerosis)?

What is tubular sclerosis (or tuberous sclerosis)?

Neurological disorde: Tuberous sclerosis is a disorder involving brain structure, skin manifestations and cognitive function. Brain malformations called tubers are characteristic. Skin abnormalities of sebaceous adenomas and subungual fibromas. See a neurologist for more information. ...Read more

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Multiple sclerosis = demyelination?

Multiple sclerosis = demyelination?

Characteristic: Demyelination refers to damage to the coverings of the nerves in the brain and spinal cord, and is very characteristic of the inflammatory process that occurs in ms. This can also occur in children with hereditary leukodystrophies, and can be associated with acquired neurological disorders. The disease modifying drugs in MS are designed to control demyelination and many work well. ...Read more

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Is multiple sclerosis a hereditary condition?

Is multiple sclerosis a hereditary condition?

In part: Hereditary risk is one factor, but the interplay between genetic background and environment is likely in this disease. Identical twins studies show about a 30% risk for MS if one twin has the disease (certainly not 100%). Population studies show certain ancestry may increase or decrease risk (e.g. Northern european ancestry high, whereas asian, african, aboriginal very low). ...Read more

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Is multiple sclerosis fatal?

Is multiple sclerosis fatal?

Not usually: Ms is a chronic neurological condition, characterized by episodes of neurological disability of variable severity and recovery. A minority of inidividuals can have a very aggressive course, and become so disabled that they are at risk of secondary medical complications which may be fatal. There are subtypes of MS which are so aggressive that a fatal outcome can happen. Fortunately these are rare. ...Read more

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How is multiple sclerosis diagnosed?

Detective Work: No one diagnostic study can stand alone to conclusively diagnose ms. A neurologist must be a detective, hunting out clues from symptoms suggesting abnormal function in the brain or spinal cord white matter, of appropriate duration (greater than 24 hours) coupled with abnormalities on examination. Mri, spinal fluid, and certain blood tests. This information can help exclude MS mimickers. ...Read more

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Who discovered multiple sclerosis?

Who discovered multiple sclerosis?

Charcot: The French neurologist Charcot is credited with identifying MS as a distinct entity for the first time. ...Read more

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Is multiple myeloma hereditary?

Is multiple myeloma hereditary?

Rarely: There are a few families where it appears hereditary. Having said this, there are families where more than one individual has the disease and the thought is that this may be due to an environmental cause. ...Read more

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Does multiple sclerosis have a hereditary component?

Does multiple sclerosis have a hereditary component?

Yes: No single gene for MS has been found or likely to be found. Multiple genes have been identified which in different population studies worldwide seem to increase risk or protect against ms. The vast majority of these genes relate to immune system function. Genetic background, combined with environmental trigger likely trigger this disorder. ...Read more

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Is multiple sclerosis preventable?

Is multiple sclerosis preventable?

No: Population studies have suggest that mononucleosis in adolescence, smoking, and possibly childhood obesity are risks for developing ms. However ms is a complex variable disease requiring genetic predisposition along with some environmental trigger(s), possibly influenced by hormones, immune system priming from certain infectious agents. ...Read more

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Is multiple myeloma genetic?

Is multiple myeloma genetic?

Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials.gov/ct2/show/NCT00582621 ...Read more

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What are common complex III mitochondrial disorders?

What are common complex III mitochondrial disorders?

Most are rare: Mitochondrial complex iii deficiency means defect in the third "complex" (structural unit) of the mitochondrial respiratory chain (chain of protein units that produces energy for our cells). All forms of complex iii deficiencies are rare. United mitochondrial foundation has excellent information on various types of mitochondrial diseases, including complex iii: http://bit.Ly/1meless. ...Read more

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What disease might mimic multiple sclerosis?

What disease might mimic multiple sclerosis?

Several potentials: Cadasil, lupus, arteritis, clippers, pernicious anemia, cervical spondylosis, lyme disease, CNS lymphoma, sjogren's, melas. If you get the point, ms may be hard to diagnose, and often need to exclude other explanations. Patterns may or may not be different, and sometimes it is important to get testing and even several opinions. ...Read more

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What is amyotrophic lateral sclerosis (als)? 

What is amyotrophic lateral sclerosis (als)? 

Motor neuron disease: A disorder of misfolded proteins, attacking nerve cell bodies in spinal cord and brain. Tends to involve weakness not numbness, and can affect legs and arms with flickering of muscles, loss of muscle mass, and evenually problems with breathing and swallowing. Unfortunately, there is no cure, and it preserves awareness. Gratefully, it is relatively rare. ...Read more

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Can multiple sclerosis be mis-diagnosed?

Not uncommonly: There are several disease states that can mimic multiple sclerosis, and MRI lesions can likewise be misleading. Since this is so very complex, it is best to seek additional opinions from physicians who specialize in the area, as the diagnosis may not always be easy to reach. ...Read more

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Multiple sclerosis (ms) vs type 1 diabetes. Which is more serious?

Apples vrs oranges: Both can cause long-term disability, but i think both can have excellent outcomes if treated expertly, in concert with a conscientious pt. Being a neurologist, cannot comment more on diabetes, but these days, the treatment and understanding of ms is amazing, and with the newer oral meds, most pts will likely have a far better outcome. So, both areas are advancing rapidly, and optimism is real. ...Read more

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Is tuberous sclerosis physically limmiting ?

Depends on severity: It is more appropriately known as tuberous sclerosis complex because it is highly varied in presentations..From simple skin lesions to complex neurological (brain/spinal cord), hearing/vision involvements causing severe disabilties. Complicated cases will require multispecialties care ...Very complicated.. ...Read more

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Dr. Harry Vinters
221 doctors shared insights

Tuberous Sclerosis (Definition)

Tuberous sclerosis is a group of two genetic disorders that affect the skin, brain/nervous system, kidneys, and heart, and cause tumors to grow. The diseases are named after a tuber- or root-shaped ...Read more