Doctor insights on:
Tryptophan Sleep Inducing Substance
Tryptophan is an amino acid. It is the precursor to the production of serotonin. The GI system will convert tryptophan to 5 hydroxytrptophan to cross the blood brain barrier and then convert the 5htp into serotonin. It does many other things in the body, but this is what it ...Read more
Topamax = 3a4 inducer. Augments gaba. Xanax & Abilify (aripiprazole) are substrates. Potential reaction? Wondering about topa + seroquel, too. Titrating from sero.
Combo: No significant adverse interaction other than sedation, as long as doses are therapeutic & monitored. ...Read more
Alpha-NREM sleep: patients with chronic pain syndromes and problems like Fibromyalgia have this kind of sleep problems. Also patients taking sedative-hypnotics. Chronic Rheumatoid Arthritis and chronic fatigue syndrome. It be thought to be hypervigilance and wakefulness or light sleep intruding on the deeper stages of sleep. ...Read moreSee 1 more doctor answer
Psychiatry: enough serotonin in the brain helps human sleep, however, taking SSRI to increase Serotonin causes insomnia if taken before sleep. why?
Complicated: This is a very complicated neurotransmitter. To give an example, there are over thirty different types of receptors -- meaning that it can do over thirty types of things. Then again, each personal is his own complex mix of variations on this. But I should tell you that SSRI's don't "increase" serotonin, they regulate it. ...Read moreSee 2 more doctor answers
Rxd topamax, xanax, abilify (aripiprazole). Topa induces 3a4. I love white grapefruit juice, which inhibits 3a4. Is this an unsafe combo esp with the topamax..?
Confusing: Topomax is a weak inducer of cyp 3a4, and maybe c19. Your biggest issue here is the grapefruit juice, which inhibits 3a4 quite significantly. This could increase the effects of both xanax and abilify (aripiprazole). Either you need to stop the grapefruit juice or drink it at a constant level. Please inform your prescribing psychiatrist about this. ...Read more
Sleep: Exercise, good diet, calming thoughts, no alcohol, no heavy meals 2 hours prior to bedtime, no nocturnal medications that can increase your metabolism. Tryptophan supplements have been touted for a long time but the evidence is scant. Speaking to your doctor for a specific cause and possible answer would be best. ...Read more
Closely: The symptoms of narcolepsy are those of parts of rem sleep intruding into wakefulness. These elements include sleepiness; hallucinations (dream imagery) while falling asleep or waking up; and cataplexy and sleep paralysis (both from the normal muscle paralysis that occurs during rem sleep). ...Read moreSee 2 more doctor answers
Is the sleep provided by mirtazapine remeron considered restful sleep or is it restless sleep? considered real sleep or is it a drug induced coma?fake
Remeron (mirtazapine) is used: to treat depression, so it depends on why you’re taking it. Without knowing more about the underlying reasons for your sleep problems, if they’re related to depression for example, it’s hard to say whether or not this will give you restful sleep. Remeron is not a sleep med but is sedating; it treats depression, which can treat insomnia that is related to depression. ...Read more
No addiction: There is no risk of developing a physiological dependence or addiction to melatonin -- meaning that your brain will not become dependent upon melatonin. Yet, as with any behavior (ie, the act of taking melatonin every night before bed) can become "addicting" or habitual thus causing a psychological addiction to needing to take melatonin for help you sleep. ...Read moreSee 2 more doctor answers
Does rozerem (ramelteon) affect the melatonin receptor, or your ability to produce melatonin naturally?
Luvox (fluvoxamine): You're referring to luvox (fluvoxamine)'s ability to inhibit the liver enzyme cyp1a2, which is needed to process both caffeine and melatonin. Both of these substances could build up to greater concentrations than expected, when taken with luvox (fluvoxamine). It is the only ssri that acts in that manner, but there are multiple other drugs that do this also. ...Read more
Can idiopathic hypersomnia diagnosis by sleep study respond to anything besides stimulants & sleep hygiene? Anything off label? Foods? Research being done?
Hyersomnia: In case of hypersomnia, the overnight sleep study is not enough alone, another study called mean sleep latency testing is needed to evaluate the severity of hypersomnia and to rule out narcolepsy. If you were told that you have idiopathic hypersomnia, i presumed that you had already mslt and narcolepsy was ruled out, anyhow stimulants, sleep hygiene modulation and regular exercise are the best. ...Read moreSee 1 more doctor answer
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