Top
10
Doctor insights on: Tryptase

Share
1

1
What is the basal level of serum tryptase in MCAS, that is, when you are not in a flare?

11.5-20 ng: The mastocytosis society and WHO consider level above 20 ng but recent publications suggest that 11.5 ng may be the level when inactive. The level may reach close to 70 ng during an attack. ...Read more

2

2
Ige=5, tryptase=3, histamine release=16% and histamine and ana=negative on blood work, are these normal? An does it clear me for a mast cell disease?

Ige=5, tryptase=3, histamine release=16% and histamine and ana=negative on blood work, are these normal? An does it clear me for a mast cell disease?

Dificult to say: These results are normal. The low tryptase level makes systemic mastocytosis (one type of mast cell disease) less likely. But, without any information about your clinical history, symptoms, etc., it is hard with only the above data to determine what is going on. Do you have hives or flushing or anaphylaxis, etc? Submit another question describing your symptoms, or talk with your doctor. ...Read more

3

3
Do i worry for repeat, non anaphalatic unicap tryptase 15? And mature tryptase <1; IgE 28; occasional low WBC & neutrophils, asthma, itch, allergies?

Do i worry for repeat, non anaphalatic unicap tryptase 15?  And mature tryptase <1; IgE 28; occasional low WBC & neutrophils, asthma, itch, allergies?

Very unclear: You need further evaluation and clarification regarding the significance of your test results. Schedule appointment with your doctor and present you questions for specific answers. ...Read more

See 1 more doctor answer
4

4
Is it possible to have mast cell activation syndrome with normal tryptase levels? If so, how can the dr be sure you really have it

No and yes: Articles have suggested that tryptase levels correlate with disease activity. If the disease is not active, the levels are usually normal. ...Read more

5

5
Tryptase testing for MCAD was 3.3 for <=10.9 ref range. Are other tests advisable if symptoms point towards MCAD?

Tryptase testing for MCAD was 3.3 for <=10.9 ref range. Are other tests advisable if symptoms point towards MCAD?

For adult Mast Cell : Activation Disorder, yes. Seek referral to a specialist in Adult Systemic Macrocytosis: Srdan Verstovsek, MD, PhD, sverstov@mdanderson.org, (713) 792-7305 or Henry Legere, MD, (512) 732-2774, austinallergist.com. Molecular genetic tests are available for the KIT gene on Chromosome 4q12 for MCAD, & for the SCN9A gene on Chr. 2q24.3 & SCN10A gene on Chr. 3p22.2 for Small Fiber Neuropathy. ...Read more

6

6
Is it possible to have mast cell activation syndrome with normal tryptase levels? If so, how can the dr be sure you really have it

No and yes: Articles have suggested that tryptase levels correlate with disease activity. If the disease is not active, the levels are usually normal. ...Read more

7

7
Can you have MCAS (Mast Cell Activation Syndrome) without an elevated tryptase level, even while symptomatic?

No: If you have symptoms and the tryptase is normal, it is highly unlikely to be from MCAS. However anaphylaxis to food is not always associated with elevated tryptase level. It would be helpful if you can provide us with a description on the types of symptoms you have been experiencing during the attack. ...Read more

9

9
What is the basal level of serum tryptase in MCAS, that is, when you are not in a flare?

11.5-20 ng: The mastocytosis society and WHO consider level above 20 ng but recent publications suggest that 11.5 ng may be the level when inactive. The level may reach close to 70 ng during an attack. ...Read more

10

10
Should you induce allergic reaction for tryptase blood test? I read sample timing matters?

Should you induce allergic reaction for tryptase blood test? I read sample timing matters?

Timing matters: In anaphylaxis, the tryptase level should be obtained no more than 2 hrs after the reaction occurs. However anaphylaxis to food often does not cause elevated tryptase level. Why would you want to trigger an allergic action to get a positive result since not all anaphylaxis lead to elevated tryptase level? ...Read more