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Doctor insights on: Triple Negative Breast Cancer Treatment

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What is the prognosis for triple negative breast cancer?

What is the prognosis for triple negative breast cancer?

Need more info...: All else being equal, women with triple negative breast cancer have a worse prognosis than those who are receptor-positive; however, prognosis is highly correlated with the size of the cancer and the presence of cancer within the axillary lymph nodes. Furthermore, some women are more responsive to chemo than others, which will affect prognosis. ...Read more

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Dr. Barry Rosen
4,357 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Tell me the metastatic triple negative breast cancer survival rates?

Tell me the metastatic triple negative breast cancer survival rates?

Depends: Survival rates depend on multiple factors; age, response to treatment, stage of disease, your overall health. This is a conversation best had with your medical oncologist. ...Read more

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What are the triple positive breast cancer survival rates?

What are the triple positive breast cancer survival rates?

Depends: Other factors such as stage can contribute to survival rates. Please discuss this with your doctor in context of all the other factors that can contribute to survival rates here is a good review of breast cancer http://www.Cancer.Net/cancer-types/breast-cancer. ...Read more

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Does Triple Negative breast cancer spread to the bladder?

Does Triple Negative breast cancer spread to the bladder?

Not common: breast cancer can metastasize anywhere but nodes, lung, brain, bone are more common sites. ...Read more

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O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

Yes they are: by now sentinel lymph node are the standard of care for breast cancer surgery and staging, and yes they are very accurate. node is negative is a very good news that will make the cancer early stage and hopefully cureable ...Read more

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32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy. What is survival rate?

32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy.  What is survival rate?

Need Clarification!: Are you sure your breast cancer was triple positive(or was it triple Negative)??? TCH is commonly used chemotherapy for triple negative, so please double check and let us know. Then we can give you survival figures. In general, small tumors(Stage 1 and stage 2) have very good survival rate and high cure rates. ...Read more

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Survival rate for triple neg receptors for early stage breast cancer after chemo treatment? No lymph nodes involve, stage 1b, grade 2, mastec done

Survival rate for triple neg receptors for early stage breast cancer after chemo treatment?  No lymph nodes involve, stage 1b, grade 2, mastec done

Excellent: According to adjuvant online (www.Adjuvantonline.Com), you have about an 82% 10 yr survival rate based on your specific information provided. This is only an estimate since there are details I do not have such as type of chemotherapy being used. For triple negative breast cancer, these survival rates are quite excellent. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

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Treatment for her2 breast cancer?

Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Adjuvant tamoxifen or other chemotherapy for ER pr negative cancer?

Adjuvant tamoxifen or other chemotherapy for ER pr negative cancer?

Chemotherapy: Tamoxifen is only used for patients whose tumors are positive for er and/or pr. ...Read more

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Dr. Richard Orr Dr. Orr
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What are the latest treatments on triple negative breast cancer?

Dr. Richard Orr Dr. Orr
12 doctors agreed:
What are the latest treatments on triple negative breast cancer?

Chemotherapy: Triple negative implies the absence of estrogen and Progesterone receptors, as well as the absence of overexpression of the her-2 gene. Because of this, endocrine manipulation (tamoxifen, arimidex, etc. Doesn't work, nor does herceptin (trastuzumab). In addition to surgery (and sometimes radiotherapy), most triple negative patients receive combination chemotherapy. ...Read more

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What is longterm prognosis for grade 3, stage 1b, triple positive breast cancer, double mastectomy and 6 treatments of TCH with one year of herceptin, (trastuzumab)?

What is longterm prognosis for grade 3, stage 1b, triple positive breast cancer, double mastectomy and 6 treatments of TCH with one year of herceptin, (trastuzumab)?

Better now: Exact prognosis is not possible, but your oncologist should discuss your prognosis with based on population statistics, such as Adjuvant! Online, or better still, your Oncotype Dx score based on the gene profile of your cancer. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No: This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. ...Read more

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Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Often: There is increasing data based on the oncotype DX test in women with 1-3 positive notes that shows that some women will not get much benefit from chemo and some will get a great deal. It can be useful in cases where a woman is reluctant to take chemo. This is done on tissue that has been already removed. Most oncologists believe that women who have multiple positive nodes should get chemotherapy. ...Read more

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What are statistical odds for cancer returning in a 63 yr old woman 20 yrs after treatment for stage 1 breast cancer (lumpectomy, chemo, & radiation)?

What are statistical odds for cancer returning in a 63 yr old woman 20 yrs after treatment for stage 1 breast cancer (lumpectomy, chemo, & radiation)?

Low, but not zero.: First of all, congratulations on being a 20-yr survivor! it is impossible to give you a number or even a range without knowing more specifics about your cancer, however, the fact that it hasn't returned in 20 years certainly puts you in favorable statistical category. I suggest that you meet with your medical oncologist to discuss this, as well as any measures you can take to prevent a recurrence. ...Read more

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Is radiation treatment always necessary for breast cancer?

Is radiation treatment always necessary for breast cancer?

Radiation&breastCA: Every pt has the choice of mastectomy or breast conserving treatment. Some time after mastectomy radiation is added if we are worried the ca might have a high risk of coming back. Breast conserving tx is a minimal surgery followed by radiation. This allows the pt to keep their breast and hasa the same recurrence rate as a mastectomy. ...Read more

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DCIS, left breast, biopsy itself removed high grade cancer cells, lumpectomy path 100% cancer free. Radiation necessary? What about proton therapy?

DCIS, left breast, biopsy itself removed high grade cancer cells, lumpectomy path 100% cancer free. Radiation necessary? What about proton therapy?

It depends: It may depend on your age. Radiotherapy to your involved breast may be required as it is the standard of care. Ask your doctor and let us know what advice you receive. Tamoxifen is another medication recommended after completion of Radiotherapy. ...Read more

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How long is the chemotherapy for a stage 2a node negative breast cancer?

How long is  the chemotherapy for a stage 2a node negative breast cancer?

It depends: There are several chemotherapy options for stage 2a breast cancer. Characteristics of the patient and the cancer are required to make a decision on the type of chemotherapy (and whether chemotherapy is even necessary). Chemotherapy would be anywhere from about 8 weeks to a year (herceptin-or trastuzumab treatment, if recommended, requires a year of treatment). ...Read more

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Dr. Mark Hoepfner
1,063 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more


Dr. Michael Thompson
192 doctors shared insights

Cancer Treatment (Definition)

Treatment for cancer usually depends on type, stage, patient's performance status, age, comorbidities. For a list of treatments please ...Read more