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Doctor insights on:
Trilineage Hematopoiesis
1
Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms
Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read more
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2
Is plasma cell myeloma hereditary?
Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more
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3
Differences between myeloid leukemia and lymphoid leukemia?
Type of cell : Lymphoid and myeloid reference the cell type involved in the leukemia. There are different cell types within the lymphoid and within the myeloid groups. We need to identify that cell type to know what treatments will be needed for that specific leukemia.. ...Read more
4
Does stem cell transplantation treat hematologic cancer?
Yes: Stem cell transplant is used to treat leukemias and lymphomas, both are types of hematologist malignancies. ...Read more
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5
Is hairy cell leukemia hereditary?
No: Leukemia is generally not hereditary but having a first degree relative with leukemia may slightly increase your risk. ...Read more
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6
Peripheral t-cell lymphoma cure: chop induction+ifosfamide/mtx + autologous transplant or romidepsim+brenduximab?
Complex problem: Cannot comment with 2 lines of information. Need the entire clinical context. If you seek more detailed information get a formal second opinion. ...Read more
7
Is revlimid (lenalidomide) effective for acute myelogenous leukemia?
Possibly: If the leukemia develops out of a myelodysplasia and has evidence of a 5q-, then possibly. But, the results are mediocre at best. Not curative by any stretch but could possibly slow the leukemia down for a short time. Hope this helps. ...Read more
8
What is nonclonal mast cell activation disorder?
Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more
9
Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.
They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more
10
Effects of leukemia drugs: mylotarg and cytosine arabinoside?
Mylotarg-cytarabine: Open these links: http://www.Drugs.Com/mtm/mylotarg.Html http://www.Drugs.Com/mtm/cytarabine.Html.
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11
Is sickle cell anemia hereditary?
Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more
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12
Immature white blood cells, leukemia, and gleevec, (imatinib) how are these related?
Gleevec (imatinib): Gleevec (imatinib) is indicated for a condition called chronic myelogeneous leukemia as well as given to patient with philadelphia positive acute lymphoblastic leukemia. Immature white blood cells which is called blast would be found in acute leukemia. It also can be found in chronic myelogenous leukemia. ...Read more
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13
What is better to treat lymphocytic leukemia gleevec (imatinib) or bone marrow transplant?
Type of Leukemia?: More details are needed to answer this question, specifically what is the leukemia type? Is it acute lymphoblastic leukemia, chronic lymphocytic leukemia, or are you referring to chronic myeloid leukemia? Please ask this question again with the additional information so it can be answered. ...Read more
14
Does alpha thalassemia causes leukemia?
No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read more
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15
Can Philadelphia chromosome positive Chronic Myeloid Leukemia turn into Pre-B-Acute Lymphoblastic Leukemia?
No: You would have to be very unlucky to have a second clone of rapidly dividing cells which is a cancer. CML would not switch to ALL. ...Read more
16
Is diffused b cell lymphoma genetic?
Not really: While there may be a genetic suscepibiltiy to developing lymphoma it is not truly a genetic disease. ...Read more
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17
Life expectancy of myeloma patients after autologous stem cell transplant?
Myeloma : There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information. ...Read more
18
Can rituxan (rituximab) treat my hairy cell leukemia?
Generally, yes: Rituxan (rituximab) is an antibody that binds the surface of B lymphocytes, which includes hairy cell leukemia. By itself it can induce remissions, but it is more effective when given in combination with other agents. Here is a link to a recent paper: http://www.ncbi.nlm.nih.gov/pubmed/25195120 ...Read more
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Are stem cell transplants for multiple myeloma effective?
Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more
20
Can gleevec (imatinib) cure retinoblastoma?
No data yet...: Gleevec (imatinib) inhibits a number of tyrosine kinases in cells (c-kit, pdgfralpha, c-abl) . There is very recent data that Gleevec (imatinib) may have activity in retinoblastoma, but these experiments where done on isolated retinoblastoma cells grown in culture. There are no clinical trials showing that Gleevec (imatinib) can treat retinoblastoma. Future clinical trials may be planned to address this question. ...Read more
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